[Sulforaphane regulates mitochondrial homeostasis through adenosine monophosphate-activated protein kinase signaling to treat acute carbon monoxide poisoning induced brain injury in rats].

Objective: To explore the neuroprotective effect and molecular mechanism of sulforaphane (SFN) on acute carbon monoxide poisoning (ACOP) in rats.

Methods: A total of 135 healthy adult male Sprague-Dawley (SD) rats were randomly divided into normal control group, ACOP model group, and SFN intervention group, with 45 rats in each group. The ACOP animal model was reproduced using carbon monoxide (CO) inhalation in a hyperbaric oxygen chamber, while the normal control group was allowed to breathe fresh air freely.

Retinal Layer and Choroidal Changes in Deep and Scuba Divers: Evidence of Pachychoroid Spectrum-Like Findings.

Diving is an intense physical activity under hyperbaric and hyperoxic conditions. The aim of this study is to evaluate the long-term effects of diving on the thicknesses of retinal layers and retinal anatomy in professional deep and scuba divers. The study included 52 eyes of deep divers who dive to depths of more than 130 feet (ft), 49 eyes of scuba divers who dive up to 130 ft, and 66 eyes of the control group, consisting of nondiving but regularly exercising males.

Examining the practical importance of nonstationary cardio-respiratory coupling detection in breathing training: a methodological appraisal.

This study investigates changes in cardiorespiratory coupling during clinic breathing training and its impact on autonomic nervous functioning compared with heart rate variability (HRV). A total of 39 subjects undergoing dynamic electrocardiogram-recorded breathing training were analyzed. Subjects were divided into early- and late-training periods, and further categorized based on changes in HRV indexes.

Hyperbaric oxygen therapy enables pain reduction and healing in painful chronic wounds, including in calciphylaxis.

Background: The effects of hyperbaric oxygen therapy (HBOT) on wound healing have been demonstrated mainly in diabetic foot ulcer.

Objectives: To study the efficacy and safety of HBOT in chronic painful wounds, excluding diabetic foot ulcers.

Methods: From 2008 to 2021, patients with chronic wounds showing no clinical improvement for more than 1 month, who were in pain despite the use of level 2 or 3 analgesics, and who had undergone HBOT sessions, were included in a monocentric retrospective study.

Hypotension after unilateral versus bilateral spinal anaesthesia: A Systematic review with meta-analysis.

Background: Spinal anaesthesia is frequently used in surgical procedures involving the lower abdomen and extremities, however, the occurrence of hypotension remains a common and clinically important adverse effect. Unilateral spinal anaesthesia seems to be a promising approach to minimise this complication but the effectiveness of this remains controversial.

Objective: A meta-analysis was undertaken to evaluate the superiority of unilateral spinal anaesthesia over bilateral spinal anaesthesia with regard to the incidence of hypotension and other complications.

Hyperbaric Oxygen Therapy for Veterans With Combat-Associated Posttraumatic Stress Disorder: A Randomized, Sham-Controlled Clinical Trial.

Cumulative data indicate that new protocols of hyperbaric oxygen therapy (HBOT) may induce neuroplasticity and improve clinical symptoms of patients suffering from posttraumatic stress disorder (PTSD). The aim of the current study was to evaluate the effects of HBOT on veterans with combat-associated PTSD (CA-PTSD) in a randomized, sham-controlled trial. Male veterans aged 25-60 years with CA-PTSD, with a Clinician-Administered PTSD Scale for (CAPS-5) score above 20, were included.

Central retinal artery occlusion following surgery for thyroid eye disease: A case report.

Rationale: Thyroid eye disease (TED) is the most common orbital disorder in adults and significantly affects patient health. Orbital decompression surgery is an important treatment option. Central retinal artery occlusion (CRAO) after orbital medial wall decompression is rare in patients with TED.

Treatment of cerebral radiation necrosis using hyperbaric oxygen therapy in a child: illustrative case.

Background: Cerebral radiation necrosis (RN) is an uncommon sequela that occurs in up to 25% of irradiated patients. This can occur 6 months to several years after therapy and create symptoms of headaches, focal neurological deficits, seizures, or behavioral changes. Management can involve corticosteroids, antiplatelet drugs, surgery, and hyperbaric oxygen therapy (HBOT).

Pseudomonas Labyrinthitis Complicating Acute Otitis Media: Case Report.

Bacterial labyrinthitis has been rarely described. incrimination is even exceptional. Herein, we present a case of pseudomonas labyrinthitis and discuss diagnosis, value of imaging, treatment and prognosis of this entity.

Risk prediction score for high spinal block in patients undergoing cesarean delivery: a retrospective cohort study.

Background: High spinal block is a serious complication of spinal anesthesia. However, findings regarding its associated risk factors are inconsistent, and no studies have reported a relevant risk prediction score. We aimed to determine the risk prediction score for high spinal block in patients who were induced spinal anesthesia for cesarean delivery.

A nursing-led sepsis response team guiding resuscitation with point-of-care ultrasound: A review and model for improving bundle compliance while individualizing sepsis care.

A dysregulated host response to infection resulting in life-threatening organ dysfunction defines the onset of sepsis. Unfortunately, sepsis is common, costly, and deadly. The Surviving Sepsis Campaign publishes regularly updated, evidence-informed, detection, and treatment guidelines culminating in time-sensitive care "bundles.

Chaperone-mediated autophagy (CMA) confers neuroprotection of HBO preconditioning against stroke.

Previous attempts to identify neuroprotective targets for acute ischemic stroke by studying ischemic cascades and devising ways to suppress these pathways have failed in translational research. We hypothesized that studying the molecular determinants of endogenous neuroprotection, namely, the tolerance against ischemic stroke conferred by hyperbaric oxygen (HBO) preconditioning, via a well-established paradigm would reveal new neuroprotective targets. By a combination of proteomics, KEGG pathway analysis, lysosome fraction and western blot analysis, we found that chaperone-mediated autophagy (CMA) was activated by HBO preconditioning.

Comparative efficacy of conservative, hyperbaric oxygen, and endovascular retinal surgery approaches in central retinal artery occlusion.

Purpose: To assess and compare the efficacy of three treatment modalities for central retinal artery occlusion (CRAO): conservative therapy, hyperbaric oxygen therapy (HBOT), and endovascular retinal surgery (ERS).

Patients And Methods: We retrospectively analyzed the cases of CRAO patients treated at the Toyama University Hospital. Their age range was 44-87 years; a balanced gender distribution was observed.

Prostate cancer theragnostics biomarkers: An update.

Biomarkers are molecules such as proteins, genes, or other substances that may be tested to determine the stage of the tumor in a patient. The role of prostate cancer biomarkers is pivotal and the combination of prostate cancer immunotherapy with efficient biomarkers has emerged as a beneficial treatment strategy and its use has increased rapidly. The two primary objectives of this current prostate cancer early detection programs were recognizing non-symptomatic individuals with prostate cancer requiring prostatic core biopsy and identifying men with prostate cancer who might benefit from definitive medical treatment.

Analysis of Adherence to AAO-HNSF Clinical Practice Guidelines for Sudden Hearing Loss.

Objective: To assess adherence to the 2019 American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNSF) guidelines for the diagnosis and management of sudden hearing loss (SHL) and sudden sensorineural hearing loss (SSNHL).

Study Design: Retrospective cohort.

Setting: TriNetX, a de-identified healthcare database.

Induction of Cerebral Arterial Gas Embolism in Rat.

We present a methodological approach for preclinical research of cerebral arterial gas embolism (CAGE), a condition characterized by gas bubbles within the cerebral circulation causing multifocal ischemia. The current work describes two surgical methods to induce CAGE in the rat: one with injection of air via the external carotid artery (ECA), thereby sacrificing the vessel, and one via direct injection into the common carotid artery (CCA). Male Wistar rats were used and divided into groups (n=5) to undergo either the ECA- or CCA-entry method with injection of different air emboli volumes (6000, 7000 and 8000 nL) or sham surgery.

A systematic review and meta-analysis comparing the severity of core symptoms of attention-deficit hyperactivity disorder in females and males.

In the past decade, there have been substantial changes in diagnostic nomenclature. This study investigated sex differences in attention-deficit/hyperactivity disorder (ADHD) symptom severity based on Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV, DSM-IV(TR), and DSM-5 criteria, separating rating scale and clinical interview data in children and adults with ADHD. PubMed, PsycINFO, and Scopus were searched for published studies (1996-2021) reporting severity of attention, and hyperactivity/impulsivity in males and females.