2 results match your criteria: "Department of Human Genetics Yokohama City University Graduate School of Medicine 3-9 Fukuura[Affiliation]"
Genotype Value Decomposition: Simple Methods for the Computation of Kernel Statistics.
Adv Genet (Hoboken)
September 2022
Department of Human Genetics Yokohama City University Graduate School of Medicine 3-9 Fukuura, Kanazawa-ku Yokohama 236-0004 Japan.
Recent advances in sequencing technologies enable genome-wide analyses for thousands of individuals. The sequential kernel association test (SKAT) is a widely used method to test for associations between a phenotype and a set of rare variants. As the sample size of human genetics studies increases, the computational time required to calculate a kernel is becoming more and more problematic.
View Article and Find Full Text PDFvariants in and cause neurodevelopmental disorders.
Ann Clin Transl Neurol
March 2018
Department of Biochemistry Hamamatsu University School of Medicine 1-20-1 Handayama, Higashi-ku Hamamatsu 431-3192 Japan.
Objective: () and () isoforms of Calcium/calmodulin-dependent protein kinase II (CaMKII) play a pivotal role in neuronal plasticity and in learning and memory processes in the brain. Here, we explore the possible involvement of - and -CaMKII variants in neurodevelopmental disorders.
Methods: Whole-exome sequencing was performed for 976 individuals with intellectual disability, developmental delay, and epilepsy.