2 results match your criteria: "Department of Hematology Kobe City Medical Center General Hospital Kobe Japan.[Affiliation]"
Complete detection of FR1 to FR3 primer-based PCR patterns of immunoglobulin heavy chain rearrangement in the BIOMED-2 protocol is associated with poor prognosis in patients with diffuse large B-cell lymphoma.
EJHaem
August 2024
Department of Hematology Kobe City Medical Center General Hospital Kobe Japan.
Article Synopsis
- Somatic hypermutations (SHMs) in the immunoglobulin heavy chain (IgH) gene are common in diffuse large B-cell lymphoma (DLBCL) and are known to result in immunogenic neoantigens, but their prognostic impact hasn't been extensively studied.
- The BIOMED-2 PCR protocol, a standard for analyzing lymphoid malignancies, can miss some cases due to these SHMs, prompting the design of three primer sets to enhance detection.
- A study of 301 DLBCL patients showed that complete detection of IgH V PCR patterns via this improved approach correlated with worse overall survival and progression-free survival compared to patients with different patterns, indicating its potential utility in clinical prognosis.
We report here a patient with extremely indolent mantle cell lymphoma (MCL) who had progressed and required immunochemotherapy 20 years after diagnostic splenectomy. Non-nodal, indolent MCL patients may progress after such an extraordinary long indolent phase, and we recommend lifelong follow up for such cases.
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