2 results match your criteria: "Department of Genome Sciences University of Washington Seattle WA USA.[Affiliation]"
Barrett's Esophagus is a neoplastic condition which progresses to esophageal adenocarcinoma in 5% of cases. Key events affecting the outcome likely occur before diagnosis of Barrett's and cannot be directly observed; we use phylogenetic analysis to infer such past events. We performed whole-genome sequencing on 4-6 samples from 40 cancer outcome and 40 noncancer outcome patients with Barrett's Esophagus, and inferred within-patient phylogenies of deconvoluted clonal lineages.
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- Human activities, like hydropower development, have significantly altered the habitats of the threatened Snake River fall Chinook salmon (SRFCS), leading to changes in their juvenile life history, such as more yearlings migrating to sea compared to historical patterns.
- Researchers hypothesized that this shift in life history could have a genetic basis, investigating whether faster-growing offspring from parents that migrated as subyearlings are more likely to do the same, confirmed through heritability estimates and growth rate modeling.
- Interestingly, the study also revealed that offspring from hatchery-reared parents grew the fastest, indicating cross-generational plasticity from artificial breeding practices, highlighting the complex evolutionary influences on this species due