2 results match your criteria: "Department of Genetics and Human Genetics Institute of New Jersey Piscataway[Affiliation]"
Tracking N- and C-termini of C. elegans polycystin-1 reveals their distinct targeting requirements and functions in cilia and extracellular vesicles.
PLoS Genet
December 2022
Rutgers, The State University of New Jersey, Department of Genetics and Human Genetics Institute of New Jersey Piscataway, Piscataway, New Jersey, United States of America.
The cilium acts as an antenna receiving and sending signals, the latter via extracellular vesicles (EVs). In C. elegans and mammals, the Autosomal Dominant Polycystic Kidney Disease (ADPKD) gene products polycystin-1 (PC1) and polycystin-2 (PC2) localize to both cilia and EVs, act in the same genetic pathway, and function in a sensory capacity, suggesting ancient conservation.
View Article and Find Full Text PDFIsolation, profiling, and tracking of extracellular vesicle cargo in Caenorhabditis elegans.
Curr Biol
May 2022
Rutgers, The State University of New Jersey, Department of Genetics and Human Genetics Institute of New Jersey Piscataway, 145 Bevier Road, Piscataway, NJ 08854, USA. Electronic address:
Extracellular vesicles (EVs) may mediate intercellular communication by carrying protein and RNA cargo. The composition, biology, and roles of EVs in physiology and pathology have been primarily studied in the context of biofluids and in cultured mammalian cells. The experimental tractability of C.
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