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Phenotypic and behavioral defects induced by iron exposure can be transferred to progeny in Caenorhabditis elegans.

Biomed Environ Sci

December 2008

Key Laboratory of Developmental Genes and Human Disease of Ministry of Education, Department of Genetics and Developmental Biology Southeast University, Nanjing 210009, Jiangsu, China.

Objective: Previous work has showed that excess iron accumulation is harmful to reproduction and even promotes death; however, whether the multiple biological toxicity of iron (Fe) exposure could be transferred to progeny remains unknown. The present study used Caenorhabditis elegans to analyze the multiple toxicities of iron exposure and their possible transferable properties.

Methods: Three concentrations of iron sulfate solution (2.

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