7 results match your criteria: "Department of General Clinic[Affiliation]"
Bmal1 knockout aggravates Porphyromonas gingivalis-induced periodontitis by activating the NF-κB pathway.
J Appl Oral Sci
February 2025
Sichuan University, West China Hospital of Stomatology, National Clinical Research Center for Oral Diseases, State Key Laboratory of Oral Diseases, Department of General Clinic, Chengdu, China.
Background: Circadian rhythm disorders and NF-κB are closely linked and can exacerbate periodontitis. However, the mechanisms via which circadian rhythm-related genes influence periodontitis are not yet fully understood.
Objective: We investigated the effect of brain and muscle Arnt-like protein-1 (BMAL1) on the NF-κB pathway and downstream inflammatory factors on periodontitis.
Mechanisms of mechanical force in periodontal homeostasis: a review.
Front Immunol
September 2024
The State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Article Synopsis
- Mechanical forces can influence periodontal health by enhancing metabolism in tissues, but excessive or absent forces can lead to damage or atrophy.
- A systematic search of scientific databases revealed key mechanisms affected by mechanical forces, including immune defense, extracellular matrix metabolism, and the roles of specific proteins and stem cells in periodontal health.
- The review highlights how these mechanisms work together to maintain periodontal homeostasis and offers insights for future research directions to better understand force impacts on periodontal health.
Urbanization impact on scorpion stings: An epidemiological study.
Toxicon
September 2024
Medical School of Uninovafapi University Center, Brazil; Department of General Clinic (DCG) of Federal University of Piaui, Brazil.
Article Synopsis
- * It analyzes data from 376 populous cities and finds a weak negative correlation between urbanization and scorpion stings in 2009.
- * Despite a higher occurrence of scorpionism in urban areas, urbanization is not the primary factor in the rise of scorpion accidents, especially in tropical and subtropical regions.
Occlusal trauma aggravates periodontitis through the plasminogen/plasmin system.
Oral Dis
July 2024
The State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Sichuan, China.
Article Synopsis
- Periodontitis, a common oral disease, is worsened by occlusal trauma, leading to increased fibrin deposition and inflammation.
- The study used 84 mice to analyze the effects of occlusal trauma on periodontitis, measuring various proteins related to fibrin and its degradation.
- Findings indicate that occlusal trauma enhances fibrin accumulation while suppressing the plasminogen/plasmin system, exacerbating the severity of periodontitis.
Network Pharmacology and Experimental Verification Reveal the Regulatory Mechanism of Chuanbeimu in Treating Chronic Obstructive Pulmonary Disease.
Int J Chron Obstruct Pulmon Dis
March 2024
Department of General Practice, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, People's Republic of China.
Background: Chronic obstructive pulmonary disease (COPD) is a common respiratory disorder in pulmonology. Chuanbeimu (CBM) is a traditional Chinese medicinal herb for treating COPD and has been widely utilized in clinical practice. However, the mechanism of CBM in the treatment of COPD remains incompletely understood.
View Article and Find Full Text PDFPreliminary assessment of a portable Raman spectroscopy system for post-operative urinary stone analysis.
World J Urol
January 2022
Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Purpose: We aimed to evaluate the reliability of a portable device that applies Raman spectroscopy at an excitation wavelength of 1064 nm for the post-operative analysis of urinary stone composition.
Materials And Methods: Urinary stone samples were obtained post-operatively from 300 patients. All samples were analyzed by the portable Raman spectroscopy system at an excitation wavelength of 1064 nm as well as by infrared spectroscopy (IR), and the results were compared.
Smartpath: a platform for teaching glomerulopathies using machine learning.
BMC Med Educ
April 2021
Department of General Clinic and coordinator of the Immunogenetics and Molecular Biology Laboratory (LIB - UFPI), Federal University of Piauí, Teresina, PI, Brazil.
Background: With the emergence of the new coronavirus pandemic (COVID-19), distance learning, especially that mediated by information and digital communication technologies, has been adopted in all areas of knowledge and at all levels, including medical education. Imminently practical areas, such as pathology, have made traditional teaching based on conventional microscopy more flexible through the synergies of computational tools and image digitization, not only to improve teaching-learning but also to offer alternatives to repetitive and exhaustive histopathological analyzes. In this context, machine learning algorithms capable of recognizing histological patterns in kidney biopsy slides have been developed and validated with a view to building computational models capable of accurately identifying renal pathologies.
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