Malnutrition exacerbating neuropsychiatric symptoms on the Alzheimer's continuum is relevant to the cAMP signaling pathway: Human and mouse studies.

Introduction: Malnutrition correlates with neuropsychiatric symptoms (NPSs) in Alzheimer's disease (AD); however, the potential mechanism underlying this association remains unclear.

Methods: Baseline and longitudinal associations of nutritional status with NPSs were analyzed in 374 patients on the AD continuum and 61 healthy controls. Serum biomarkers, behavioral tests, cerebral neurotransmitters, and differentially gene expression were evaluated in standard and malnourished diet-fed transgenic APPswe/PSEN1dE9 (APP/PS1) mice.

Synergistic Intramolecular Charge Transfer Promotes Au Nanoclusters with Enhanced NIR-II Photoluminescence.

Gold nanoclusters (Au NCs) protected by molecular ligands represent a new class of second-generation near-infrared (NIR-II) luminescent materials that have been widely studied. However, the photoluminescence efficiencies of most NIR-II emitting Au NCs in aqueous solution are generally lower than 0.2%, and to fully exploit the advantages of AuNCs in the NIR-II region, improving their photoluminescence efficiency has become an urgent need.

Breast Cancer-Derived Extracellular Vesicles Modulate the Cytoplasmic and Cytoskeletal Dynamics of Blood-Brain Barrier Endothelial Cells.

Extracellular vesicles (EVs) from brain-seeking breast cancer cells (Br-EVs) breach the blood-brain barrier (BBB) via transcytosis and promote brain metastasis. Here, we defined the mechanisms by which Br-EVs modulate brain endothelial cell (BEC) dynamics to facilitate their BBB transcytosis. BEC treated with Br-EVs show significant downregulation of Rab11fip2, known to promote vesicle recycling to the plasma membrane and significant upregulation of Rab11fip3 and Rab11fip5, which support structural stability of the endosomal compartment and facilitate vesicle recycling and transcytosis, respectively.

Pain in very preterm infants-prevalence, causes, assessment, and treatment. A nationwide cohort study.

Studies on pain in preterm infants have usually been confined to observations of painful procedures, and information from extremely preterm infants is limited. Using registry data from a Swedish nationwide cohort, this study explored the epidemiology of pain in very preterm infants, its causes, assessments, and treatment strategies. We included liveborn infants <32 weeks' gestational age (GA) discharged between January 2020 and June 2024.

Extracellular Vesicles From Bone Marrow-Derived Macrophages Enriched in ARG1 Enhance Microglial Phagocytosis and Haematoma Clearance Following Intracerebral Haemorrhage.

Microglial phagocytosis of haematomas is crucial for neural functional recovery following intracerebral haemorrhage (ICH), a process regulated by various factors from within and outside the central nervous system (CNS). Extracellular vesicles (EVs), significant mediators of intercellular communication, have been demonstrated to play a pivotal role in the pathogenesis and progression of CNS diseases. However, the regulatory role of endogenous EVs on the phagocytic capacity of microglia post-ICH remains elusive.

Optical properties and photobleaching of wildfire ashes aqueous extracts.

Wildfires can severely degrade soils and watersheds. Post-fire rain events can leach ashes and altered dissolved organic matter (DOM) into streams, impacting water quality and carbon biogeochemistry. The photochemical properties and persistence of DOM from wildfire ash leachates are not well understood.

Prevalence of dementia in Singapore: Changes across a decade.

Introduction: The study aimed to assess changes in the prevalence of dementia in Singapore over the past decade.

Methods: The Well-being of the Singapore Elderly (WiSE) 2023 and the WiSE 2013 studies were comprehensive, single-phase, cross-sectional surveys conducted among older adults aged ≥60 years in Singapore. WiSE 2023 included 2010 older adults and 1798 informants, whereas WiSE 2013 comprised 2565 older adults and 2421 informants.

Astrocyte-derived exosomes regulate sperm miR-34c levels to mediate the transgenerational effects of paternal chronic social instability stress.

The effects of chronically stressing male mice can be transmitted across generations by stress-specific changes in their sperm miRNA content, which induce stress-specific phenotypes in their offspring. However, how each stress paradigm alters the levels of distinct sets of sperm miRNAs is not known. We showed previously that exposure of male mice to chronic social instability (CSI) stress results in elevated anxiety and reduced sociability specifically in their female offspring across multiple generations because it reduces miR-34c levels in sperm of stressed males and their unstressed male offspring.

A steric hindrance-regulated probe with single excitation dual emissions for self-adaptive detection of biothiols and HS in human urine samples and living cells.

Sulfur-containing small molecules, mainly including cysteine (Cys), homocysteine (Hcy), glutathione (GSH), and hydrogen sulfide (HS), are crucial biomarkers, and their levels in different body locations (living cells, tissues, blood, urine, saliva, ) are inconsistent and constantly changing. Therefore, it is highly meaningful and challenging to synchronously and accurately detect them in complex multi-component samples without mutual interference. In this work, we propose a steric hindrance-regulated probe, NBD-2FDCI, with single excitation dual emissions to achieve self-adaptive detection of four analytes.

Hepatic Rupture in HELLP Syndrome: Report of Two Patients and a Review of Peripartum Surgical Care and Transfusion.

Herein, we report the cases of two patients with hemolysis, elevated liver enzymes, and low platelets syndrome who underwent emergent Cesarean sections that were complicated by massive hemorrhage due to undiagnosed hepatic rupture. Intraoperative General Surgery team intervention, early activation of massive transfusion protocol, hemostatic resuscitation, and transfer to ICU resulted in the survival of both patients.

A Cascade of Abscess, Fasciitis, and Obstruction: Rare Presentation of Perforated Appendicitis.

Fasciitis and abdominal abscess, followed by bowel obstruction could be the first manifestation of a silent perforated appendicitis. So, clinicians should evaluate the patient's complete clinical picture to prevent misdiagnoses and delays in care.

Early Detection and One-Year Follow-Up of Subclavian Steal Syndrome Treated With Traditional Chinese Medicine: A Case Report.

Subclavian steal syndrome (SSS) often goes undiagnosed because of its variable and subtle symptoms, highlighting the need for innovative diagnostic approaches. This case report explores the integration of traditional Chinese medicine (TCM) in both diagnosing and managing SSS, marking a pioneering contribution to the field. An 80-year-old woman with persistent dizziness, unresponsive to conventional treatments, underwent TCM pulse diagnosis, which revealed significant inter-arm pulse discrepancies.

Properties of encapsulated raspberry powder and its efficacy for improving the color stability and amino acid composition of pastırma cemen pastes with different pH during long term cold-storage.

Unlabelled: In this study, the changes in the physicochemical properties, color stability, and amino acid composition of cemen paste (CP) produced by adjusting to different pH levels (3.0, 4.0, 5.

Nutrient composition of human milk of Indian mothers: relation with maternal and infant anthropometry.

The aim of the study was to determine the nutrient composition of human milk (HM) of Indian mothers and investigate its association with maternal and infant anthropometric measures. Human milk is an ideal source of nutrition for optimum growth and development of infant. Among Indian mothers, HM composition data is scanty, especially during prolonged lactation.

Chitosan research progress for smart packaging applications: a literature review.

The environmental crisis was brought on by composites made of synthetic materials that are not biodegradable. Eco-friendly replacement materials for non-biodegradable composites is biodegradable composites. The poisonous remnants are avoided because of how the environment breaks them down.

Production of instant cassava () tuber flour for : optimization of process conditions.

Unlabelled: Production of instant cassava tuber flour for is an appealing process because of a significant reduction in cooking time, it involves less tedious preparation, the flour has improved odor with a significant increase in shelf life, and is of better quality. However, the optimum cassava fermentation and precooking parameters; two critical unit operations in the process, as well as their effects on the quality and shelf life of the product have not been studied elaborately. The Doehlert design was employed to optimize the fermentation and the precooking processes of cassava () tuber to produce instant flour for .

Multiomic analysis of lactylation and mitochondria-related genes in hepatocellular carcinoma identified MRPL3 as a new prognostic biomarker.

Background: Recent research has highlighted lactate's crucial role in epigenetic regulation, particularly by influencing histone modifications that drive the initiation and progression of hepatocellular carcinoma (HCC). While mitochondria are known to regulate tumor behavior, the interaction between lactate metabolism and mitochondrial function in cancer tissues remains underexplored. Understanding this relationship may provide deeper insights into tumor metabolic reprogramming and reveal novel therapeutic targets for HCC and other malignancies.

An introduction to antibacterial materials in composite restorations.

The longevity of direct esthetic restorations is severely compromised because of, among other things, a loss of function that comes from their susceptibility to biofilm-mediated secondary caries, with being the most prevalent associated pathogen. Strategies to combat biofilms range from dental compounds that can disrupt multispecies biofilms in the oral cavity to approaches that specifically target caries-causing bacteria such as . One strategy is to include those antibacterial compounds directly in the material so they can be available long-term in the oral cavity and localized at the margin of the restorations, in which many of the failures initiate.

Speckle-illumination spatial frequency domain imaging with a stereo laparoscope for profile-corrected optical property mapping.

Significance: Laparoscopic surgery presents challenges in localizing oncological margins due to poor contrast between healthy and malignant tissues. Optical properties can uniquely identify various tissue types and disease states with high sensitivity and specificity, making it a promising tool for surgical guidance. Although spatial frequency domain imaging (SFDI) effectively measures quantitative optical properties, its deployment in laparoscopy is challenging due to the constrained imaging environment.

Lipoic acid improves wound healing through its immunomodulatory and anti-inflammatory effects in a diabetic mouse model.

Objectives: Diabetes mellitus is a chronic disease that has become more prevalent worldwide because of lifestyle changes. It leads to serious complications, including increased atherosclerosis, protein glycosylation, endothelial dysfunction, and vascular denervation. These complications impair neovascularization and wound healing, resulting in delayed recovery from injuries and an elevated risk of infections.

Role of imaging in the diagnosis and management of mixed epithelial and stromal tumors of the kidney: Case series and comprehensive review.

Mixed epithelial and stromal tumor (MEST) of the kidney is a rare benign neoplasm composed of both stromal and epithelial components. MEST is mainly seen in adults with a strong predilection for perimenopausal women with history of hormone replacement therapy. While MEST is generally benign, there are reported cases of malignant transformation and adverse clinical outcomes.

Giant triple negative pregnancy-associated breast cancer (PABC) in a young woman: From diagnosis to therapy step by step: A case report.

Pregnancy-associated breast cancer (PABC) presents unique challenges. This type of breast cancer is often more aggressive than that diagnosed in nonpregnant women, and its diagnosis is frequently delayed. Several factors contribute to this delay, including the physiological changes that occur during pregnancy, such as breast enlargement, breast tenderness and increased tissue density, which can mask early signs of malignancy.

Nicotinamide mononucleotide restores impaired metabolism, endothelial cell proliferation and angiogenesis in old sedentary male mice.

Aging is accompanied by a decline in neovascularization potential and increased susceptibility to ischemic injury. Here, we confirm the age-related impaired neovascularization following ischemic leg injury and impaired angiogenesis. The age-related deficits in angiogenesis arose primarily from diminished EC proliferation capacity, but not migration or VEGF sensitivity.

Devonian-Mississippian magmatism related to extensional collapse in Svalbard: implications for radiating dyke swarms.

Background: Despite extensive studies of the Mesozoic-Cenozoic magmatic history of Svalbard, little has been done on the Paleozoic magmatism due to fewer available outcrops.

Methods: 2D seismic reflection data were used to study magmatic intrusions in the subsurface of eastern Svalbard.

Results: This work presents seismic evidence for west-dipping, Middle Devonian-Mississippian sills in eastern Spitsbergen, Svalbard.