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Article Synopsis
  • Gastroesophageal reflux disease (GERD) is commonly treated with proton-pump inhibitors (PPIs), but potassium-competitive acid inhibitors (P-CABs) are becoming more popular and were evaluated for their effectiveness and safety.
  • A systematic review analyzed 14 randomized controlled trials involving nearly 4,900 participants to compare the efficacy of P-CABs to PPIs and placebo, focusing on symptom improvement and adverse effects.
  • Results indicated that P-CABs have a higher healing rate and effectiveness than PPIs or placebo, with similar safety outcomes, suggesting they are a viable alternative treatment for GERD.
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