1 results match your criteria: "Department of Exploratory Biopharmaceutics and Drug Delivers Pharmaceutical Research Institute[Affiliation]"
Effect of delivery route on pulmonary response to oncostatin M.
J Drug Target
February 2002
Department of Exploratory Biopharmaceutics and Drug Delivers Pharmaceutical Research Institute, Bristol-Myers Squibb Company, New Brunswick, NJ 08903-0191, USA.
The effect of delivery route on lung tissue response to oncostatin M (OM) was evaluated in isolated perfused rat lung (IPRL) and normal human bronchial epithelial cell line BEAS-2B in vitro models. In this study, the extent of induction of the cytokine IL-6 by OM was examined as evidence for local pharmacological activity in response to OM in lung tissue. OM stimulated dose-dependent release of IL-6 in both BEAS-2B cells and IPRL after exposure of either the apical (AP) or basolateral (BL) side of the epithelium.
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