Science to practice: will contrast agents for molecular imaging of angiogenesis help overcome the limitations of functional vascular imaging?

Schmieder and colleagues introduced a new molecular magnetic resonance (MR) probe with a promising lipophilic gadolinium chelate complex that provides high relaxivity. Results of in vivo experiments clearly demonstrate the excellence of the probe for longitudinally monitoring α(v)β(3) integrin expression in tumors. In addition, the authors have developed a robust nonrelaxometric analysis method with which to quantify the spatial distribution of molecular MR probes.