Real-world experience of diagnosis, disability, and daily management in parents of children with different genetic developmental and epileptic encephalopathies: a qualitative study.

Purpose: This study describes the experience of parents of children with developmental and epileptic encephalopathies (DEE) and how the disease impacts their daily lives.

Materials And Methods: A descriptive qualitative study was conducted using purposeful sampling. Twenty-one parents of children with DEEs caused by SCN1A, KCNQ2, CDKL5, PCDH19, and GNAO1 variants were included.

Cancer Organoids as reliable disease models to drive clinical development of novel therapies.

On September 23-24 (2024) the 6th Workshop IRE on Translational Oncology, titled "Cancer Organoids as Reliable Disease Models to Drive Clinical Development of Novel Therapies," took place at the IRCCS Regina Elena Cancer Institute in Rome. This prominent international conference focused on tumor organoids, bringing together leading experts from around the world.A central challenge in precision oncology is modeling the dynamic tumor ecosystem, which encompasses numerous elements that evolve spatially and temporally.

Maximizing the safety and sustainability of MXenes.

Safe and Sustainable by Design (SSbD) is a new regulatory concept guiding chemical and material innovation. The European Commission has recommended a two-stage SSbD framework and plan to revise it based on stakeholder feedback. The framework involves establishing key (re)design SSbD principles and assessment of the final innovation, however the applicability of the framework to advanced materials remains to be addressed.

Drug resistant Mycobacterium tuberculosis strains have altered cell envelope hydrophobicity that influences infection outcomes in human macrophages.

In recent decades, drug resistant (DR) strains of Mycobacterium tuberculosis (M.tb), the cause of tuberculosis (TB), have emerged that threaten public health. Although M.

Nonlinear coupling of closely spaced modes in atomically thin MoS nanoelectromechanical resonators.

Nanoelectromechanical systems (NEMS) incorporating atomic or molecular layer van der Waals materials can support multimode resonances and exotic nonlinear dynamics. Here we investigate nonlinear coupling of closely spaced modes in a bilayer (2L) molybdenum disulfide (MoS) nanoelectromechanical resonator. We model the response from a drumhead resonator using equations of two resonant modes with a dispersive coupling term to describe the vibration induced frequency shifts that result from the induced change in tension.

Implementing digital respiratory technologies for people with respiratory conditions: A protocol for a scoping review.

The value of 'data-enabled', digital healthcare is evolving rapidly, as demonstrated in the COVID-19 pandemic, and its successful implementation remains complex and challenging. Harmonisation (within/between healthcare systems) of infrastructure and implementation strategies has the potential to promote safe, equitable and accessible digital healthcare, but guidance for implementation is lacking. Using respiratory technologies as an example, our scoping review process will capture and review the published research between 12th December 2013 to 12th December 2023.

Delivering Patient-Centered Care with Respect to Patient Education and Health Literacy in Athletic Training Job Settings.

Context: A patient-centered care (PCC) environment allows athletic trainers (ATs) to develop trusting relationships with patients, enabling them to make the most informed care decisions. To provide PCC, the AT should assess health literacy and deliver quality patient education.

Objective: To explore the lived experiences of ATs from different job settings to identify how they deliver PCC specific to health literacy and patient education.

The abundance, removal efficiency, and characteristics of microplastics in three urban wastewater treatment plants (WWTPs) on the southern coast of the Caspian Sea.

Wastewater treatment plants (WWTPs) are one of the major collection points of microplastics (MPs). The MPs in influents and effluents of WWTPs were assessed for three cities on the southern coast of the Caspian Sea in the winter and spring seasons. The MP removal rate of WWTPs ranged between 71.

CNN-Based Cross-Modality Fusion for Enhanced Breast Cancer Detection Using Mammography and Ultrasound.

Breast cancer is a leading cause of mortality among women in Taiwan and globally. Non-invasive imaging methods, such as mammography and ultrasound, are critical for early detection, yet standalone modalities have limitations in regard to their diagnostic accuracy. This study aims to enhance breast cancer detection through a cross-modality fusion approach combining mammography and ultrasound imaging, using advanced convolutional neural network (CNN) architectures.

Urinary miRNA Expression in Pre-Eclampsia During Early and Mid-Pregnancy.

Pre-eclampsia (PE) is a serious condition affecting 2-8% of pregnancies worldwide, leading to high maternal and fetal morbidity and mortality. MicroRNAs (miRNAs), small non-coding RNA molecules, have emerged as potential biomarkers for various pregnancy-related pathologies, including PE. MiRNAs in plasma and serum have been extensively studied, but urinary miRNAs remain underexplored, especially during early pregnancy.

Lactoferrin as a Versatile Agent in Nanoparticle Applications: From Therapeutics to Agriculture.

Nanoparticles (NPs) have emerged as a potent choice for various applications, from drug delivery to agricultural studies, serving as an alternative and promising methodology for future advancements. They have been widely explored in delivery systems, demonstrating immense promise and high efficiency for the delivery of numerous biomolecules such as proteins and anticancer agents, either solely or modified with other compounds to enhance their capabilities. In addition, the utilization of NPs extends to antimicrobial studies, where they are used to develop novel antibacterial, antifungal, and antiviral formulations with advanced characteristics.

Microstructural and Surface Texture Evaluation of Orthodontic Microimplants Covered with Bioactive Layers Enriched with Silver Nanoparticles.

Bacterial infections are a common cause of clinical complications associated with the use of orthodontic microimplants. Biofilm formation on their surfaces and subsequent infection of peri-implant tissues can result in either exfoliation or surgical removal of these medical devices. In order to improve the properties of microimplants, hybrid coatings enriched with silver nanoparticles, calcium, and phosphorus were investigated.

Piezosurgery in Third Molar Extractions: A Systematic Review.

: The aim of this systematic review was to evaluate the clinical efficacy, benefits, and limitations of piezosurgery in tooth extractions compared to conventional methods. Piezosurgery has emerged as a minimally invasive alternative, promoting better preservation of soft tissues and bone structures. Understanding its impact on postoperative outcomes such as pain, swelling, trismus, and bone healing is critical for its application in oral surgery; We restricted our search to English-language articles published between 1 January 2004 and 28 August 2024, in PubMed, Scopus, and Web of Science.

Patent Overview of Innovative Hyaluronic Acid-Based Hydrogel Biosensors.

Hyaluronic acid-based hydrogels are emerging as highly versatile materials for cost-effective biosensors, capable of sensitive chemical and biological detection. These hydrogels, functionalized with specific groups, exhibit sensitivity modulated by factors such as temperature, pH, and analyte concentration, allowing for a broad spectrum of applications. This study presents a patent-centered overview of recent advancements in hyaluronic acid hydrogel biosensors from 2003 to 2023.

Bithiophene Imide-Based Self-Assembled Monolayers (SAMs) on NiOx for High-Performance Tin Perovskite Solar Cells Fabricated Using a Two-Step Approach.

Three new bithiophene imide (BTI)-based organic small molecules, (), (), and (), with varied alkyl side chains, were developed and employed as self-assembled monolayers (SAMs) applied to NiOx films in tin perovskite solar cells (TPSCs). The NiOx layer has the effect of modifying the hydrophilicity and the surface roughness of ITO for SAM to uniformly deposit on it. The side chains of the SAM molecules play a vital role in the formation of a high-quality perovskite layer in TPSCs.

Atherogenic index of plasma and the clinical outcome of patients with acute coronary syndrome: a meta-analysis.

Background: The atherogenic index of plasma (AIP) has been related to an increased risk of coronary artery disease. However, previous studies evaluating the prognostic role of AIP for acute coronary syndrome (ACS) showed inconsistent results. This meta-analysis was conducted to systematically evaluate the association between AIP and the risk of major cardiovascular adverse events (MACE) of patients with ACS.

Chemical-functional characterization of and and dietary supplementation in post-weaning pigs.

Introduction: As the livestock industry grapples with the need for sustainable land, maintaining production systems, and reducing antimicrobial resistance, the application of functional nutrition emerges as a potential solution.

Aim: In line with the One Health principles, this study aims to evaluate functional properties of and and assess the effects of their dietary supplementation on piglets' health.

Materials And Methods: A chemical-functional characterization was conducted before and after digestion.

Efficacy of telerehabilitation for total knee arthroplasty: a meta-analysis based on randomized controlled trials combined with a bibliometric study.

Background: Physical therapy (PT) is widely employed in osteoarthritis (OA). This study aimed to explore the research development of PT for OA and to identify the emerging treatment, and verify its efficacy.

Materials And Methods: The Web of Science Core Collection was used to conduct the bibliometric analysis.

Collective Interactions of Quantum-Confined Excitons in Halide Perovskite Nanocrystal Superlattices.

Collective optical properties can emerge from an ordered ensemble of emitters due to interactions between the individual units. Superlattices of halide perovskite nanocrystals exhibit collective light emission, influenced by dipole-dipole interactions between simultaneously excited nanocrystals. This coupling changes both the emission energy and rate compared to the emission of uncoupled nanocrystals.

A Multilayer Network Model for Motor Competence from the View of the Science of Complexity.

Motor competence is related to a large number of correlates of different natures, forming together a system with flexible parts that are synergically and cooperatively connected to produce a wide range of motor outcomes that cannot be explained from a predetermined linear view or a unique mechanism. The diversity of interacting correlates, the various connections between them, and the fast changes between assessments at different time points are clear barriers to the study of motor competence. In this manuscript, we present a multilayer framework that accounts for the theoretical background and the potential mathematical procedures necessary to represent the non-linear, complex, and dynamic relationships between several underlying correlates that emerge as a motor competence network.

Thermoelectric Modulation of Neat TiCT MXenes by Finely Regulating the Stacking of Nanosheets.

Emerging two-dimensional MXenes have been extensively studied in a wide range of fields thanks to their superior electrical and hydrophilic attributes as well as excellent chemical stability and mechanical flexibility. Among them, the ultrahigh electrical conductivity (σ) and tunable band structures of benchmark TiCT MXene demonstrate its good potential as thermoelectric (TE) materials. However, both the large variation of σ reported in the literature and the intrinsically low Seebeck coefficient (S) hinder the practical applications.

Tailoring the Reprocessability of Thiol-Ene Networks through Ring Size effects.

Recycling thermosetting materials presents itself as a major challenge in achieving sustainable material use. Dynamic covalent cross-linking of polymers has emerged as a viable solution that can combine the structural integrity of thermosetting materials with the (re-)processability of thermoplastics. Thioether linkages between polymer chains are quite common, and their use dates back to the vulcanization of rubbers.

A cell-based Papain-like Protease (PLpro) activity assay for rapid detection of active SARS-CoV-2 infections and antivirals.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants are a continuous threat to human life. An urgent need remains for simple and fast tests that reliably detect active infections with SARS-CoV-2 and its variants in the early stage of infection. Here we introduce a simple and rapid activity-based diagnostic (ABDx) test that identifies SARS-CoV-2 infections by measuring the activity of a viral enzyme, Papain-Like protease (PLpro).

Development of a diagnostic multivariable prediction model of a positive SARS-CoV-2 RT-PCR result in healthcare workers with suspected SARS-CoV-2 infection in hospital settings.

Background: Despite declining COVID-19 incidence, healthcare workers (HCWs) still face an elevated risk of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. We developed a diagnostic multivariate model to predict positive reverse transcription polymerase chain reaction (RT-PCR) results in HCWs with suspected SARS-CoV-2 infection.

Methods: We conducted a cross-sectional study on episodes involving suspected SARS-CoV-2 symptoms or close contact among HCWs in Bogotá, Colombia.

Resonant Quantum Magnetodielectric Effect in Multiferroic Metal-Organic Framework [CHNH]Co(HCOO).

The observation of both resonant quantum tunneling of magnetization (RQTM) and resonant quantum magnetodielectric (RQMD) effect in the perovskite multiferroic metal-organic framework [CHNH]Co(HCOO).is reported. An intrinsic magnetic phase separation emerges at low temperatures due to the hydrogen-bond-modified long-range super-exchange interaction, leading to the coexistence of canted antiferromagnetic order and single-ion (Co) magnets.