Assessment of Quality of Life in Chronic Otitis Media After Type 1 Tympanoplasty - An Observational Study.

This study is aimed to assess the outcome of Type-1Tympanoplasty in patients of Chronic Otitis Media (COM)- mucosal type and document the associated hearing gain and correlate it with the improvement in Quality of life (QOL) using COMOT (Chronic Otitis Media Outcome Test) 15 scoring. A hospital based prospective study was carried out in a tertiary care centre on 80 patients of mucosal type of COM. Patients were given COMOT 15 questionnaire to score the symptoms and pure tone audiometry (PTA) was done to assess hearing level.

Refractory Secondary Hyperparathyroidism in Chronic Renal Impairment: Is Surgery a Viable Option to Achieve a Biochemical Balance in Patients Failing Medical Management?

Secondary hyperparathyroidism (SHPT) is a common complication in chronic kidney disease patients, necessitating effective management to prevent adverse outcomes. This study evaluates the efficacy of surgical intervention in achieving biochemical balance in SHPT patients resistant to medical therapy. The study includes 36 patients with SHPT who underwent subtotal parathyroidectomy following failed medical management.

A Case of Saddle Nose Deformity Secondary to Lepromatous Leprosy.

Background: Leprosy is a chronic infectious disease caused by the Mycobacterium leprae affecting most commonly skin and peripheral nerves. Patients with Lepromatous Leprosy remain asymptomatic for years, and harbor bacteria in the nasal cavity, and these patients are responsible for the transmission of the disease in the community. In the advanced stage (stages 4 and 5) the involvement of nasal septum results in saddle nose deformity in most patients.

Feasibility of Angulated Curettes in Endoscopic Ear Surgery: A Study on Goat Head Temporal Bone Models.

Transcanal endoscopic techniques have transformed the external ear canal into an operative gateway. The evolution history of endoscopic ear instruments has always been driven by the surgeon's demand in certain procedures. Because simple procedures (such as drilling and curetting) in microscopic postaural approach might become extremely difficult in the settings of Endoscopic ear surgery with the transcanal approach.

Renal Cell-Like Adenocarcinoma of Nasal Cavity: A Rare Entity Deserving Elucidation.

Unlabelled: Sino-nasal malignancies are extremely rare accounting < 1% of all malignancies and < 3% of aero-digestive tract tumors. Their surgical pathology is extremely challenging due to the enormous heterogeneity. Few of these sino-nasal tumors may possibly present histologically as clear cell neoplasm.

Asymptomatic and Incidental Middle Ear Foreign Body: A Case Report and Literature Review.

We report a rare incident of an asymptomatic foreign body discovered in the middle ear of a 14-year-old female, initially presenting for a different otological complaint. The discovery was made incidentally during routine examination, with further confirmation by HRCT and subsequent successful surgical removal. A brief review of the literature reveals that such asymptomatic cases are uncommon, as most reported instances of middle ear foreign bodies are symptomatic, presenting with a range of otological symptoms and usually necessitating removal to avert further complications.

Coin in the Oesophagus Cloaked over the Other - A Rare Case Report.

Coins continue to be the most common foreign body that kids swallow, especially younger children. There are still extremely few documented instances of children ingesting several coins in the literature, making these occurrences uncommon. It is quite uncommon to see a case of multiple coin ingestion with perfect radiological alignment.

Assessment of acoustic characteristics of speech in patients with bilateral abductor vocal cord paralysis following trans oral carbon dioxide LASER posterior cordotomy.

Aims: The study aimed to assess voice quality in patients with bilateral abductor vocal cord paralysis (BAVCP) following transoral carbon dioxide (CO2) LASER posterior cordotomy with acoustic parameters.

Materials And Methods: Twenty-five participants were recruited over a three-year duration. Voice analysis was done twice, pre-operatively and three months post-operatively in decannulated patients, with the help of Praat software (Version 6.

Management of Herpes Simplex Virus Reactivation Following Open Septorhinoplasty: A Case Report.

Herpes simplex virus (HSV) reactivation post-surgery is an important complication to watch out for in surgeries like septorhinoplasty. This case report discusses the difficulties in diagnosis and successful treatment approaches for HSV reactivation after an open septorhinoplasty, underscoring the need for increased clinical awareness. This is a case report of a 33-year-old female with no medical history and no allergies who underwent an open septorhinoplasty to correct nasal obstruction and external nasal deformity without any intraoperative complications.

Compound screening in human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies.

Regeneration of the airway epithelium restores barrier function and mucociliary clearance following lung injury and infection. The mechanisms regulating the proliferation and differentiation of tissue-resident airway basal stem cells remain incompletely understood. To identify compounds that promote human airway basal cell proliferation, we performed phenotype-based compound screening of 1,429 compounds (from the ENZO and Prestwick Chemical libraries) in 384-well format using primary cells transduced with lentiviral luciferase.

Cancer nursing research priorities: findings from a cancer nurses' consultation in Europe.

Background: Nurses are well positioned to identify the most critical issues in patient care and to determine priorities for investigation. Involving nurses in developing research priorities may increase their engagement in research and enhance the development high-quality nursing practice.

Aim: This study aimed to scope the potential topics for future cancer nursing research in Europe from the perspective of cancer nurses.

Unveiling novel susceptibility genes and drug targets for basal cell carcinoma by a cross-tissue transcriptome-wide association study.

Objective: To identify novel susceptibility genes and drug targets for basal cell carcinoma (BCC).

Methods: We performed a transcriptome-wide association study (TWAS) to identified the susceptibility genes and potential drug targets for BCC. The cross-tissue TWAS was conducted to discover the candidate genes for BCC.

Clinical, genetic, radiological characteristics and management of mediastinal paragangliomas: a literature review and case series.

Paragangliomas (PGLs) are neuroendocrine tumours (NETs) that arise from neural crest derived cells. Up to 40% of cases occur due to the presence of a pathogenic germline variant (PGV) in a known gene. Mediastinal PGLs are rare but are being diagnosed with increasing frequency.

Characteristics of Retina, Choroid, and Retrobulbar Blood Flow in Myopes With Posterior Staphyloma Using Ultra-Widefield OCTA and CDI.

Purpose: To explore the characteristics of retinal, choroidal, and retrobulbar blood flows in myopic patients with posterior staphyloma (PS) using ultra-widefield optical coherence tomography angiography (UWF-OCTA) and Color Doppler imaging (CDI).

Methods: The retrospective cross-sectional study enrolled 134 adults with high myopia from the Eye and ENT Hospital of Fudan University from December 2021 to September 2022. After propensity score matching, 45 eyes of 30 patients and 45 eyes of 32 patients were included in the PS and non-PS (NPS) groups, respectively.

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis.

Background: We investigated the corneal biomechanical properties and their genotype-phenotype correlation correlations in patients with Marfan syndrome (MFS) and ectopia lentis (EL).

Methods: Patients with MFS with EL underwent panel-based next-generation sequencing in this retrospective cohort study. The FBN1 genotypes were categorized into the dominant-negative (DN) group and the haploinsufficiency (HI) group.

Feasibility of Stepwise Technology-Based Audiometry With Rapid Results (STARR) Protocol in Minnesota Elementary Schools.

Objective: This study aims to understand the utility of a stepwise technology-based audiometry with rapid results (STARR) school screening protocol.

Study Design: A prospective cohort study.

Setting: Six elementary schools in a single school district in Minnesota.

Prospective Registry Trial of Adjuvant High-Dose Rate Brachytherapy in Unirradiated Head and Neck Cancer: 20-Year Data.

Background And Purpose: Full-dose postoperative external beam radiation therapy (EBRT)/chemoradiation is the standard of care in patients with resected, unirradiated head and neck cancer (HNC). This study aims to determine the long-term results of adjuvant high-dose rate (HDR) brachytherapy ± intermediate-dose postoperative external beam radiation therapy (EBRT)/chemoradiation in this HNC patient population.

Materials And Methods: From 2000 to 2018, a total of 152 patients diagnosed with HNC were treated with surgery and adjuvant HDR brachytherapy alone (n = 32) or combined with EBRT ± chemotherapy (n = 120).

A novel Janus nanomachine based on mesoporous silica nanoparticles anisotropically modified with PAMAM dendrimers for enzyme-controlled drug delivery.

A masking/toposelective modification approach was employed to prepare a new organic-inorganic Janus nanomaterial by attaching ethylenediamine core polyamidoamine G-4.5 dendrimers to a defined face of mesoporous silica nanoparticles. The anisotropic colloid was then sequentially functionalized on the mesoporous face with (3-isocyanatopropyl)triethoxysilane, 1-(4-aminophenyl)-2-phenylethane-1,2-dione and β-cyclodextrin to assemble a novel HO-sensitive gating mechanism.

Lemierre's Syndrome With Cavernous Sinus Thrombosis: A Life-Threatening Complication of Peritonsillar Abscess.

Lemierre's syndrome is a rare and life-threatening form of septic thrombophlebitis that can complicate head and neck infections. In most cases, septic thrombophlebitis affects the internal jugular vein. Its extension into the cerebral venous sinus is extremely rare, especially in the cavernous sinus.

Comparative Study of Vault Measurement by Pentacam, Casia2, and RTVue in Myopic Eyes After Implantable Collamer Lens Implantation.

Purpose: To compare vault measurement using Pentacam (Oculus, Germany) and two optical coherence tomography (OCT) instruments, Casia2 (Tomey Corporation, Japan) and RTVue (Optovue Inc. USA).

Methods: This comparative study recruited 95 eyes of 50 patients (mean age: 28.

To Identify and Discuss the Enablers or Facilitators and Barriers to International Medical Graduates Adapting to the United Kingdom National Health Service in a Defined Surgical Trainee Population: A Qualitative Study.

Background: International medical graduates (IMGs) play a crucial role in the United Kingdom National Health Service (NHS), yet they encounter significant challenges adapting to the NHS environment. This study aims to identify the enablers and barriers affecting the adaptation of IMGs, specifically focusing on surgical trainees in the Master of Surgery (MCh) program at Edge Hill University.

Methods: A qualitative approach was employed, utilizing an interpretivist philosophy and descriptive design.

Safety and Effectiveness of the Titanium mAXIS Stapes Prosthesis: Multicentric Short-Term Outcome.

Objective: Otosclerosis leads to ossification of the stapes footplate and is responsible for a significant number of patients having hearing loss. Stapes surgery is a treatment for otosclerosis with excellent postoperative hearing outcomes. The aim of this retrospective study was to analyze the safety and effectiveness of the titanium mAXIS prosthesis in a multicentric setting.

The intricate interrelationship of cochlear aperture and internal auditory canal diameter in pediatric normal petrous structures.

Purpose: The cochlear aperture and internal auditory canal dimensions play a pivotal role in cochlear nerve health, yet their normative data exhibit significant variability. This study seeks to establish definitive normative ranges for these dimensions and investigate their interrelationship in the context of normally developed pediatric temporal bones.

Methods: This prospective study included seventy-eight children under fifteen years, diagnosed with bilateral severe-to-profound sensorineural hearing loss and free from temporal bone deformities.