Numerical, phenotypic and functional differences in human dermal resident memory T cells between reticular dermal layers.

Background: Resident memory T (T) cells and immunosuppressive Foxp3-expressing regulatory T (regT) cells are present in healthy, non-inflamed and inflamed human skin. Both types of cells are found in both the epidermis and dermis with the dermis being much thicker than the epidermis. However, it is unclear if T and regT cells differ between reticular dermal layers in terms of number, function or characteristics.