A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session5lh0fjf1lco6fav5h8qgtekej55frh42): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

Department of Clinical Pathophysiology[... Publications | LitMetric

475 results match your criteria: "Department of Clinical Pathophysiology[Affiliation]"

Longitudinal Assessment of Cognitive Function in Survivors of Testicular Germ Cell Tumor.

Eur Urol Oncol

December 2024

2nd Department of Oncology, Comenius University and National Cancer Institute, Bratislava, Slovakia; Cancer Research Institute, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia. Electronic address:

Background And Objective: Survivors of testicular germ cell tumor (TGCT) may experience long-term cognitive changes. The aim of our prospective study was to longitudinally assess cognitive function among TGCT survivors to identify potential lasting cognitive changes over a period of 5 yr.

Methods: TGCT survivors (n = 151) completed Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog) questionnaires annually, with median time to first follow-up visit (FUV) of 8 (range 4-24) yr since completion of treatment.

View Article and Find Full Text PDF

Evaluation of continuous positive airway pressure adherence and its contributing factors.

Respir Med

November 2024

Department of Respiratory Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan. Electronic address:

Article Synopsis
  • A multicenter study involving over 1,200 patients with obstructive sleep apnea aimed to evaluate long-term adherence to CPAP therapy over periods of 90 and 365 days.
  • The study found that adherence rates were modest, with approximately 44-57% of patients meeting the criteria for consistent CPAP use, depending on the measurement standards applied.
  • Factors such as age, apnea ratio, and the interaction of BMI with oxygen desaturation levels significantly impacted adherence, highlighting the complexity of factors affecting patient compliance with CPAP therapy.
View Article and Find Full Text PDF
Article Synopsis
  • Ossifying fibroma (OF) is a benign bone lesion characterized by fibrous tissue and immature bone or cementum, often triggered by factors like trauma or dental issues, and is more common in women aged 20-40.* -
  • A rare case study of an 18-year-old man misdiagnosed with a static bone cavity revealed OF, shown as a radiolucent area on radiographs and confirmed through cone-beam computed tomography imaging.* -
  • The lesion was successfully removed, and histopathological analysis confirmed the diagnosis, highlighting the importance of accurate imaging and diagnosis to avoid confusing OF with other conditions.*
View Article and Find Full Text PDF

Multidimensional prediction of continuous positive airway pressure adherence.

Sleep Med

October 2024

Department of Respiratory Medicine, Nara Medical University, 840 Shijocho, Kashihara, Nara, 634-8521, Japan.

Objective: Continuous positive airway pressure (CPAP) is the standard treatment for obstructive sleep apnea (OSA). Unsatisfactory adherence to CPAP is an important clinical issue to resolve. Cluster analysis is a powerful tool to distinguish subgroups in a multidimensional fashion.

View Article and Find Full Text PDF

Preexisting cardiovascular disease (CVD) is a pivotal risk factor for severe coronavirus disease 2019 (COVID-19). We investigated the longitudinal (over 1 year and 9 months) humoral and cellular responses to primary series and booster doses of mRNA COVID-19 vaccines in patients with CVD. Twenty-six patients with CVD who received monovalent mRNA COVID-19 vaccines were enrolled in this study.

View Article and Find Full Text PDF

The CHADS -VASc score is a vital clinical tool for evaluating thromboembolic risk in patients with atrial fibrillation (AF). This study investigated the efficacy of the CHADS -VASc score in a cohort of 737 heterogeneous patients (mean age: 63 years) receiving care in cardiac intensive care units (CICUs), with a creatinine-based estimated glomerular filtration rate (eGFR) of ≥60 mL/min/1.73 m upon admission and discharge.

View Article and Find Full Text PDF

Assessment and management of continuous positive airway pressure therapy in patient with obstructive sleep apnea.

Respir Investig

July 2024

Department of Respiratory Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Article Synopsis
  • Obstructive sleep apnea (OSA) leads to issues like excessive daytime sleepiness and a higher risk of cardiovascular diseases, with Continuous Positive Airway Pressure (CPAP) being a key treatment for moderate to severe cases.
  • While CPAP use is often assessed with a minimum of 4 hours, longer usage (at least 6 hours) may be needed to ensure genuine improvements in daytime sleepiness and blood pressure.
  • Patient education on CPAP should be customized to their unique usage patterns and needs, promoting individualized goals to enhance therapy adherence and efficacy.
View Article and Find Full Text PDF

Squamous cell carcinoma initially occurring on the tongue dorsum: a case series report with molecular analysis.

Diagn Pathol

April 2024

Department of Pathology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, Okayama, 700-8558, Japan.

Background: Squamous cell carcinoma (SCC) of the dorsum of the tongue is extremely rare, and it clinically resembles various benign lesions. Somatic mutations in TP53 and some driver genes were implicated in the development of SCC; however, the somatic genetic characteristics of dorsal tongue SCC remain unknown. With a detailed analysis of gene mutations in dorsal tongue SCC, we aimed to better understand its biology.

View Article and Find Full Text PDF

Background: Chemotherapy-induced peripheral neuropathy (CIPN) after curative treatment for testicular germ cell tumors (GCTs) has been previously reported. It has been shown that CIPN can contribute to impaired quality of life (QOL) in cancer survivors. Herein, we aimed to evaluate CIPN in association with QOL in GCT survivors.

View Article and Find Full Text PDF
Article Synopsis
  • Chronic psychological stress is linked to Alzheimer's disease risk, with higher cortisol levels correlating with negative brain health indicators in midlife individuals.
  • A study of 277 cognitively normal participants found that increased cortisol was associated with reduced brain volume and glucose metabolism, along with higher β-amyloid accumulation.
  • Differences were noted between sexes: for women, cortisol's effects on brain health were more pronounced after menopause, while in men, cortisol correlated more with gray matter volume and memory issues.
View Article and Find Full Text PDF

Hyperplastic dental follicles (HDFs) represent odontogenic hamartomatous lesions originating from the pericoronal tissues and are often associated with impacted or embedded teeth. These lesions may occasionally feature unique calcifying bodies, known as calcifying whorled nodules (CWNs), characterized by stromal cells arranged in a whorled or spiral fashion. CWNs are typically observed in multiple calcifying hyperplastic dental follicles or regional odontodysplasia.

View Article and Find Full Text PDF

Sclerosing odontogenic carcinoma (SOC) is an exceedingly rare odontogenic carcinoma known for its locally aggressive yet indolent behavior. There have been no reports of metastasis to distant organs, except a single case involving lymph node metastasis. This report details the case of a 49-year-old female who presented with a well-demarcated radiolucent lesion in the mandible, accompanied by root resorption and tooth displacement.

View Article and Find Full Text PDF

Medical thoracoscopy/pleuroscopy has become, after bronchoscopy, the second most commonly utilized endoscopic procedure in interventional pulmonology. Due to their common origin, medical thoracoscopy/pleuroscopy and video-assisted thoracic surgery (VATS) are quite similar procedures technically. In contrast to the prevailing attitude that it should predominantly be performed by interventional pulmonologists, we believe that, like all hybrid-in-nature techniques, it should be implemented as part of a combined specialist care service/team.

View Article and Find Full Text PDF

Aims: This study aimed to determine the new cut-off value of serum angiotensin-converting enzyme (ACE) levels for detecting patients with sarcoidosis and to examine the change in ACE levels after the initiation of immunosuppressive therapy.

Methods And Results: We retrospectively examined patients in whom serum ACE levels were measured for suspected sarcoidosis between 2009 and 2020 in our institution. For patients diagnosed with sarcoidosis, changes in ACE levels were also observed.

View Article and Find Full Text PDF

An early return-to-work program for COVID-19 close contacts in healthcare during the Omicron wave in Japan.

J Infect Chemother

January 2023

Department of Quality and Safety in Healthcare, Division of Infection Control and Prevention, Fujita Health University Hospital, 1-98 Kutsukake-cho, Dengakugakubo, Toyoake, 470-1192, Japan. Electronic address:

During the coronavirus disease 2019 (COVID-19) pandemic, maintaining adequate staffing in healthcare facilities is important to provide a safe work environment for healthcare workers (HCWs). Japan's early return-to-work (RTW) program may be a rational strategy at a time when there is an increased demand for the services of HCWs. We assessed whether the early RTW program for HCWs who have been in close contact with a COVID-19 case in our hospital was justified.

View Article and Find Full Text PDF

Odontoblasts differentiate from dental papilla stem cells, but the genetic changes that occur during this process remain unclear. The aim of this study was to investigate gene expression patterns during differentiation of mouse iPS cells into odontoblast-like cells. Mouse iPS cells were cultured on a collagen type-1 scaffold with bone morphogenetic protein 4 (BMP4) and retinoic acid (RA).

View Article and Find Full Text PDF

This study investigates the response of bone marrow (particularly megakaryocytes) in mice under the influence of diclofenac sodium for 10 days using intraperitoneal injection at various doses. A fundamentally new immunomagnetic separation method was applied during the experiment, which helped obtain pure lines of bone marrow cells, particularly megakaryocytes (MC), without admixtures of other cells or their particles. The resulting cells completely retain their structure and can be used in further research.

View Article and Find Full Text PDF

Stress stimulates both the sympathetic-adrenomedullary and hypothalamus-pituitary-adrenal axes. Activation of these axes results in the release of catecholamines, which in turn affects salivary secretion. Thus, repetitive stimulation of the α-adrenergic receptor could be useful for studying the effects of chronic stress on the salivary gland.

View Article and Find Full Text PDF

Objective: The aim of the study was to determine the expression of cell proliferating marker, anti-proliferating cell nuclear antigen (anti-PCNA) and mesenchymal stem cell (MSC) markers (anti-STRO-1 and anti-CD44) in periapical periodontitis and their role in the healing of periapical lesion in periapical periodontitis.

Materials And Methods: Ninety Sprague-Dawley male rats (100 g) were divided into 3 groups: Experimental group I (EG I: n = 30), experimental group II (EG II: n=30) and control group (CG: n = 30). Periapical lesions were experimentally developed by leaving the dental pulp of maxillary first molars mesial root open to oral environment for 4 weeks.

View Article and Find Full Text PDF

Concern has been raised about the effectiveness of the coronavirus disease 2019 (COVID-19) vaccine in the population of patients with various comorbidities such as heart disease. We investigated the humoral response to the BNT162b2 mRNA COVID-19 vaccine in patients with cardiovascular disease (CVD). We measured IgG against severe acute respiratory syndrome coronavirus 2 spike receptor-binding domain (RBD-IgG) in 85 CVD patients and 179 healthcare workers (HCWs).

View Article and Find Full Text PDF

Serum Afamin a Novel Marker of Increased Hepatic Lipid Content.

Front Endocrinol (Lausanne)

December 2021

Department of Metabolic Disease Research, Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia.

Aim: Afamin is a liver-produced glycoprotein, a potential early marker of metabolic syndrome. Here we investigated regulation of afamin in a course of the metabolic disease development and in response to 3-month exercise intervention.

Methods: We measured whole-body insulin sensitivity (euglycemic hyperinsulinemic clamp), glucose tolerance, abdominal adiposity, hepatic lipid content (magnetic resonance imaging/spectroscopy), habitual physical activity (accelerometers) and serum afamin (enzyme-linked immunosorbent assay) in 71 middle-aged men with obesity, prediabetes and newly diagnosed type 2 diabetes.

View Article and Find Full Text PDF

A rare case of static bone cavity in the anterior mandibular region of a 10-year-old boy.

Int J Surg Case Rep

June 2021

Department of Oral and maxillofacial Surgery, Tokyo Dental College, 2-9-18 Kanda-Misakicho, Chiyoda-ku, Tokyo 101-0061, Japan.

Introduction: Static bone cavity (SBC) is a bone defect that develops as a result of localized pressure from tissues surrounding the mandible. It is most commonly observed in the mandibular angle of adult males caused by the submandibular gland. The condition is asymptomatic and requires no treatment.

View Article and Find Full Text PDF

The study of the incidence of cryoglobulinemia is relevant in patients with an intestinal anastomotic leak. This study aims to determine a laboratory marker of the risk of small intestine anastomotic leak. The study was based on 96 patients who were subjected to resections of segments of the small intestine with the formation of intestinal anastomoses at the State Institution "Zaytsev V.

View Article and Find Full Text PDF