9,136 results match your criteria: "Department of Clinical Nutrition.[Affiliation]"

Objectives: Recent studies have confirmed the involvement of mannose-binding lectin (MBL) in the pathogenesis of vascular complications in individuals with diabetes. Due to the discrepancy between the results of studies, a meta-analysis was conducted to evaluate MBL levels in patients with diabetes and its vascular complications.

Methods: We reviewed all observational studies published in PubMed/Medline, Scopus, EMBASE, and Web of Science Core Collection databases to identify relevant studies up to 1 April 2024.

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Patient voices on PKU care: Insights from focus groups with current and former patients.

Mol Genet Metab Rep

December 2024

Division of Genetics and Genomics, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115, USA.

Many adults with phenylketonuria (PKU) were discharged from clinics before lifelong treatment guidelines and new therapies. As part of the PKU lost to clinical care study, moderated focus groups were conducted to understand why individuals become lost to care and how to maintain patient engagement. Focus groups involved active clinic patients and those lost to PKU care.

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Objective: To examine the relationship between etiologically-based preterm birth sub-groups and early postnatal growth according to gestational age at birth.

Methods: Prospective, multinational, cohort study involving 15 hospitals that monitored preterm newborns to hospital discharge. Measures/exposures: maternal demographics; etiologically-based preterm birth sub-groups; very, moderate and late preterm categories, and feeding.

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Article Synopsis
  • The study investigates how maternal serum iodine concentrations (SIC) relate to thyroid function and various birth outcomes among pregnant women aged 18-45 in the Huizhou Mother-Infant Cohort.
  • It includes a significant sample size of 1558 mothers, analyzing SIC and thyroid health using advanced testing methods, and features case-control studies comparing mothers with gestational diabetes and newborns with small for gestational age to healthy controls.
  • Results show that high SIC in the first trimester is linked to a higher risk of small for gestational age babies and negatively affects gestational weight gain and birth size, while also indicating strong diagnostic potential for thyroid dysfunction.*
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Body Roundness Index Trajectories and the Risk of Cancer: A Cohort Study.

Cancer Med

December 2024

Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.

Background: The body rounds index (BRI), an innovative obesity indicator integrating waist circumference (WC) and height, offers a two-dimensional assessment of obesity. The relationship between BRI trajectories and cancer has been overlooked in previous studies. This study aims to explore the association between BRI trajectories and the incidence of cancer.

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Background: Smoking is a factor for hypertension. We aim to reveal novel plasma proteins mediating the relationship of smoking with hypertension and identify potential drug targets for hypertension on the basis of Mendelian randomization design.

Methods And Results: Data for smoking were selected from the largest genome-wide association study meta-analysis performed by the Genome-Wide Association Study and Sequencing Consortium of Alcohol and Nicotine Use.

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Article Synopsis
  • The Japan Society for the Study of Obesity advises aiming for a 3% weight loss over 3-6 months, but the impact of rapid weight loss on body composition is not fully understood.
  • A study focused on obese individuals used a combination of a low-carb diet, exercise, and medication to achieve a 3-5% weight loss, resulting in significant reductions in visceral fat and improvements in various health markers.
  • The results showed that moderate weight loss can effectively reduce harmful fat while preserving lean muscle, leading to better health outcomes like improved blood pressure and glucose levels, although some measures of insulin resistance didn't show significant changes.
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  • The study explores how different dietary fat intakes affect glucagon levels, crucial for lipid metabolism, using 92 twins on a low-fat diet (LFD) followed by a high-fat diet (HFD) and some on a high-protein diet (HPD).
  • Results showed a significant reduction in glucagon levels during the LFD, while transitioning to the HFD led to a marked increase in glucagon and a decrease in free fatty acids. The HPD further elevated glucagon levels despite stable fasting amino acids.
  • Overall, the findings suggest that a high-fat diet boosts glucagon levels and improves the glucagon-to-insulin ratio, potentially helping to prevent fat accumulation in the
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Article Synopsis
  • Vitamin D plays a role in Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD), particularly affecting secondary hyperparathyroidism in hemodialysis (HD) patients, and while cholecalciferol is recommended for vitamin D deficiency, its effects on CKD-MBD are not entirely clear.
  • An observational study involved 22 HD patients with vitamin D levels between 30-50 ng/mL receiving cholecalciferol to boost their levels above 75 ng/mL, comparing baseline biochemical markers with those at higher vitamin D levels.
  • The study found that 73% of participants achieved the target vitamin D level in about 7.5 weeks with a total dose of 525,000
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Validity and Reliability of the Transcultural Arabic Adaptation of the Food-Mood Questionnaire Among College Students.

Int J Environ Res Public Health

November 2024

Department of Clinical Nutrition and Dietetics, Research Institute of Medical and Health Sciences, College of Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.

A culturally adapted screening tool for mental health and dietary quality is needed to address the significant challenges in mental health and suboptimal diets among college students. The purpose of this study was to validate the Food-Mood Questionnaire (FMQ), originally developed in English, among Arab college students. Students attending the University of Sharjah were invited to complete the questionnaire ( = 224).

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Micronization of wholewheat flour increases iron bioavailability from hydrothermally processed wheat flour dough.

Food Res Int

December 2024

Department of Nutritional Sciences, King's College London, SE1 9NH, UK; School of Food Science & Nutrition, University of Leeds, LS2 9JT, UK. Electronic address:

Cereal products contribute significantly to dietary intake of essential minerals. In wheat, iron and zinc are stored in specific grain structures including the aleurone, scutellum and embryo. Wheat cell walls are resistant to digestion in the human gastrointestinal tract and therefore this study investigated the hypothesis that physical disruption of the cell walls would increase the bioaccessibility and bioavailability of iron and zinc from wheat-based foods.

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Article Synopsis
  • The study explores the potential therapeutic effects of interleukin 6 receptor (IL-6R) blockade in autoimmune diseases (ADs) using Mendelian randomization analysis based on large-scale genetic data.
  • Results suggest that IL-6R blockade can increase the risk of asthma and eczema, while decreasing the risk of ankylosing spondylitis, Crohn's disease, type 1 diabetes, and possibly multiple sclerosis.
  • The findings highlight the complexity of using IL-6R blockade in treatment, indicating both protective and harmful effects on different autoimmune conditions.
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Background: Eating disorders are complex mental health conditions that significantly impact physical and mental well-being. Current research suggests a potential link between eating disorders and the gut microbiota, highlighting the role of gut-brain communication and its influence on nutrient absorption. Probiotics, which are beneficial bacteria, have shown promise in modulating the gut microbiota and may offer complementary interventions in the treatment of eating disorders.

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Associations of an overall healthy lifestyle with the risk of metabolic dysfunction-associated fatty liver disease.

BMC Public Health

November 2024

CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, PR China.

Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) affects up to one-third of the global population. Since no approved pharmacotherapy for MAFLD is available, lifestyle modification remains the cornerstone of clinical care. Our study aims to evaluate the association of an overall healthy lifestyle with MAFLD risk.

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A novel optical strategy for ALP detection and development of matched smartphone app.

Sci Rep

November 2024

Chongqing Municipality Clinical Research Center for Geriatric diseases, Chongqing University Three Gorges Hospital, Chongqing, China.

Alkaline phosphatase (ALP) is a reliable biomarker for various diseases, making the development of new detection methods highly significant. Herein, we report a simple and accurate dual-signal optical detection strategy for measuring ALP activity across the entire clinical range in adults. Based on this, we designed a smartphone app to eliminate the limitations of large instruments, enabling real-time field detection.

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(1) Background: General nutrition knowledge is a fundamental pillar of well-being and healthy lifestyles. This study aimed to measure the general nutrition knowledge questionnaire (GNKQ) scores of overweight and obese participants who joined a pilot randomized controlled trial (RCT) and the association between changes in GNKQ scores and changes in anthropometric measures. (2) Methods: A total of 30 and 25 participants had completed the trial at the 3- and 6-month visits, respectively.

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Objective: This study aimed to investigate the potential of LINE, a major messaging app and social media platform in Japan, as an effective tool to enhance the health and dietary behaviors of young Japanese women who face health and dietary challenges.

Methods: A 6-week randomized controlled trial employing an intention-to-treat analysis was conducted on first-year female students (age range, 18-23 years) from one university and two junior colleges in Mie Prefecture. The participants were allocated to either an intervention group (n = 54) or a control (n = 55) group.

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Background: This study investigated the correlation between the systemic immune-inflammation index (SII) and the systemic inflammation response index (SIRI) and all-cause, cardiovascular, and kidney disease mortality in patients with diabetic nephropathy (DN). It aimed to provide a new predictive assessment tool for the clinic and a scientific basis for managing inflammation in DN.

Methods: The data utilized in this study were obtained from the National Health and Nutrition Examination Survey (NHANES) database, spanning 1999 to 2018.

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Retrospective analysis of factors contributing to poor prognosis among 271 pediatric patients with tracheal stenosis treated with slide tracheoplasty.

J Thorac Cardiovasc Surg

November 2024

Department of Laboratory Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China. Electronic address:

Article Synopsis
  • The study aimed to identify factors that lead to negative postsurgical outcomes in children with congenital tracheal stenosis (CTS) who underwent slide tracheoplasty (STP).
  • It found that conditions like unilateral lung hypoplasia and bilateral bronchomalacia significantly increased the risk of airway complications, mechanical ventilation time, and longer hospital stays.
  • Key factors influencing patient survival included weight and tracheal diameter, highlighting the importance of thorough assessment and tailored management for these patients.
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Type II Diabetes mellitus (T2DM) and associated complications primarily diabetic retinopathy cases are rising with an alarming rate. Prolong hyperglycemia along with the aldose reductase (AR) activity play a pivotal role in the development of oxidative stress in the aqueous humor and diabetic retinopathy. AR catalyzes conversion of glucose into sorbitol and or fructose get diffuse into lens leading to impaired electrolyte balance and cataract formation.

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Purpose: This study aimed to assess the relationship between Chinese adapted MIND diet and cognitive functioning and performance in different cognitive domains across a cross-section of Chinese middle-aged and older adults.

Methods: This cross-sectional study used baseline data from the Lifestyle and Healthy Ageing in Chinese Square Dancers study. Chinese adapted MIND diet scores were calculated from a detailed retrospective semi-quantitative food frequency questionnaire assessment.

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Gut microbiota and gut-derived metabolites are altered and associated with dietary intake in women with polycystic ovary syndrome.

J Ovarian Res

November 2024

Postgraduate Program in Endocrinology and Metabolism, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, 90035-003, Brazil.

Background: Disturbances in the gut microbiota may act as mechanisms influencing the interplay between dietary factors and metabolic disorders. Studies have demonstrated that these alterations are associated with the diagnosis of polycystic ovary syndrome (PCOS). Within this context, we aimed to investigate associations between gut microbiota, gut-derived metabolites (short-chain fatty acids [SCFAs] and indole-3-propionic acid [IPA]), and dietary intake in women with PCOS.

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