Txicological Aspects of Newly Designed Macrocyclic Complexes of Iron(II).

Brine shrimp lethality of a new series of 16 to 26-membered macrocycles of iron(II) containing tetraaza groups and prepared by the template condensation reaction of diacarboxylic acids (malonic, succinic, glutaric or adipic) with 2,6-diaminopyridine and diethylenetriamine in 1:2:2 molar ratios have been studied. Structures and bonding of the macrocyclic complexes have been proposed based on elemental analyses, IR, electronic, X-ray and mass spectral studies. An octahedral geometry for these complexes has been proposed as the binding sites are the nitrogen atoms of the macrocycles.

Antiandrogen and Antimicrobial Aspects of Coordination Compounds of Palladium(II), Platinum(II) and Lead(II).

Synthesis, characterization and antimicrobial activities of an interesting class of biologically potent macrocyclic complexes have been carried out. All the complexes have been evaluated for their antimicrobial effects on different species of pathogenic fungi and bacteria. The testicular sperm density, testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails and biochemical parameters of reproductive organs have been examined and discussed.

Effects of Organoantimony(III) Compounds of Sterically Hindered Bifunctional Tetradentate Ligands on the Reproductive System of Male Rats.

The antifertility activity of organoantimony(III) complexes PhSb[RC(NC(6)H(4)S)CH(2)(NC(6)H(4)S)CR'] {R' = CH(3) (R(1)) and R = R' = CF(3) (R(2))} derived from corresponding sterically hinlered bifuinctional tetradentate ligands in the male rats was determined. The administration of compounds R(1) and R(2) at the dose level of 20 mg/kg. b.

Synthesis, Characterization and Antifertility Activity of New Unsymmetrical Macrocyclic Complexes of Tin(II).

A new series of unsymmetrical macrocyclic complexes of tin(ll) has been prepared by the template process using bis(3-oxo-2-butylidene)propane-1,3-diamine as precursor. This affords a method to synthesize these complexes with various ring sizes. The tetradentate macrocyclic precursor [N(4)mL] reacts with SnCl(2) and different diamines in a 1:1:1 molar ratio in refluxing methanol to give complexes of the type [Sn(N(4)mL)Cl(2)].

Toxicity, Spectroscopic Characterization and Electrochemical Behaviour of New Macrocclic Complexes of Lead(II) and Palladium(II) Metals.

Tetraazamacrocyclie complexes of lead and palladium have been synthesized by the template process using the bis(benzil)ethylenediamine precursor. The tetradentate macrocycle (maL) reacts with PbCl(2), PdCl(2) and different diamines in a 1:1:1 molar ratio in methanol to give several solid complexes of the types [Pb(maL)(R)Cl(2)] and [Pd(maL)(R)]Cl(2) (where R = 2,6-diaminopyridine or 1,2-phenylenediamine). The macrocycle and its metal complexes have been characterized by elemental analysis, molecular weight determinations, molar conductivity, IR, (1)H NMR, (13)C NMR, electronic, mass and electrochemical studies.

Fertility Inhibitor Heterobimetallic Complexes of Platinum(II) and Palladium(II): Synthetic, Spectroscopic and Antimicrobial Aspects.

Synthetic, spectroscopic and antimicrobial aspects of some fertility inhibitor heterobimetallic complexes have been carried out. These heterobimetallic chelates [M(C(5)H(5)N(3))(2)M(2)'(R)(4)]Cl(2) (M = Pd or Pt and M' = Si, Sn, Ti and Zr) have been successfully synthesinzed via the reaction of M(C(5)H(7)N(3))(2)Cl(2) with group four or fourteen dichlorides in 1:2 stoichiometric proportions. The products were characterized by elemental analyses, molecular weight determinations, magnetic susceptibility measurements, conductance, and IR multinuclear NMR and electronic spectral studies.

Synthesis, characterization, in vitro and in vivo screening of unsymmetrical borole complexes of 2-hydroxy-N-phenylbenzamide and its derivatives.

Biochemical aspects, synthesis and characterization of some boron complexes of 2-hydroxy-N-phenylbenzamide (HOPhBenz) and its semicarbazone (HOPhBenz.SCZH) and thiosemicarbazone (HOPhBenz.TSCZH) are described.

Synthetic, Spectroscopic and Biocidal Aspects of Heterobimetallic Complexes Comprising Platinum(II) and a Group Four or Fourteen Element.

Heterobimetallic complexes with varying amines have been synthesized by the reaction of [Pt(C(2)H(8)N(2))(2)]Cl(2) with group four or fourteen organometallic dichlorides, viz., R(2)MCl(2) and Cp(2)M'Cl(2) in a 1:2 molar ratio in MeOH (where M=Si or Sn, M'= Ti or Zr and R=Ph or Me). These complexes have been characterized by elemental analysis, molecular weight determinations, magnetic measurements, conductance, IR, (1)H NMR and electronic spectra.

Synthetic, biochemical, antifertility and antiinflammatory aspects of manganese and iron complexes.

Manganese(II) and iron(II) macrocyclic complexes of polyamide groups have been synthesized by the template codensation of diamines (2,6 diaminopyridine, 1,2 phenylenediamine and 1,3 phenylenediame) and triamine (diethylenetriamine) with phthalic acid in 1:2:2 molar ratios. On the basis of elemental analysis, IR, electronic, magnetic moment, Mössbauer, mass and X-ray spectral studies, octahedral structure has been assigned to [M(N4macn)Cl2] (M = Mn(II) and Fe(II), n = 1 to 4) complexes. The complexes have been screened in vitro against a number of fungi and bacteria to assess their growth inhibiting potential.

Nematicidal, Fungicidal and Bactericidal Activities of Manganese (II) Complexes with Heterocyclic Sulphonamide Imines.

Some manganese(II) complexes derived from different sulphadrugs and heterocyclic ketones have been prepared. These complexes have been characterized on the basis of elemental analyses, molecular weight determinations, conductivity measurements, infrared, ESR and magnetic measurements. The spectral data suggest that the ligands act in a monobasic, bidentate manner coordinating through nitrogen atom.

Toxicity of Certain Penta-Coordinated Organotin(IV) and Tetra-Coordinated Tin(II) Complexes of Heterocyclic beta-Diketones Against the Larvae of Aedes Aegypti (Liston).

Some organotin(IV) and tin(II) complexes of composition R(3)Sn[R'COC:CON(C(6)H(5))N:CCH(3)] (where R=C(4)H(9), R'=CH(3), C(3)H(5), p-ClC(6)H(4); R=C(6)H(5), R'=C(6)H(5) and p-ClC(6)H(4)) and Sn[p-ClC(6)H(4)COC:CON(C(6)H(5))N:CCH(3)](2) were screened for their toxicity against Aedes aegypti larvae. Organotin(IV) complexes were more active than tin(II) complexes.

Oxidimetric determination of thiourea, thiosulphate and sulphite with thallic perchlorate in acid medium.

Conditions have been established for the titrimetric estimation of thiourea, thiosulphate and sulphite with thallic perchlorate, with visual end-points, in perchloric and sulphuric acid medium. In the direct determination, chloride and bromide interfere. In the indirect iodometric determination.

Studies on metallochromic indicators-III Hematoxylin and hematein.

The use of hematoxylin and hematein as metallochromic indicators in direct EDTA titration of Zr(4+), Th(4+), Bi(3+), VO(+), Ga(3+), In(3+), Al(3+), Pb(+), Zn(2+), Mn(2+), Cd(2+), Cu(2+), Ni(2+), Co(2+), Mg(2+), and a few rare earths is described. Aluminium is titrated directly in presence of acetate buffer, lactic or glycoliic acid being used as auxiliary complexing agent. Mixtures of two metal ions can be titrated if one is Bi(3+) and the other Al(3+), Pb(2+), Zn(2+), Cu(2+), Cd(2+), La(3+), Ce(3+), Pr(3+), Nd(3+), Sm(3+), Gd(3+) or Er(3+).

Polarography of molybdenum in aspartic acid solution.

The polarographic behaviour of Mo(VI) in solutions of aspartic acid is reported. In 0.01M acid, two waves are obtained, but at pH 4 only one, and they are diffusion controlled.