6,753 results match your criteria: "Department of Cardiology Tokyo Medical & Dental University Tokyo Japan.[Affiliation]"
Prognostic impact of outpatient loop diuretic reduction patterns in patients with chronic heart failure.
Int J Cardiol Heart Vasc
December 2024
Department of Cardiology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
Article Synopsis
- The study examined how outpatient oral loop diuretic dose changes affect the health outcomes of heart failure patients, following 679 individuals between 2015 and 2019.
- It categorized patients into three groups based on their diuretic dose: no reduction, single reduction, and successive reductions, finding that fewer deaths and heart failure hospitalizations were linked to dose reductions.
- Ultimately, the research concluded that reducing loop diuretic doses can be a sign of better prognosis for patients with heart failure.
Characteristics and In-Hospital Outcomes of Patients With Myocardial Infarction With Non-Obstructive Coronary Arteries - Insights From the Real-World JAMIR Database.
Circ J
October 2024
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine.
Article Synopsis
- Researchers analyzed the characteristics and outcomes of 22,236 patients with myocardial infarction, focusing on the 286 diagnosed with non-obstructive coronary arteries (MINOCA) from the Japan Acute Myocardial Infarction Registry.
- MINOCA patients were generally younger and had fewer risk factors compared to those with obstructive coronary artery disease (MI-CAD), but in-hospital mortality rates were similar between the two groups.
- The study found higher non-cardiac mortality in MINOCA patients, especially among the elderly, indicating a need for better overall management and care for younger patients to improve their health outcomes.
A multiparametric heart failure score at baseline is associated with long-term outcome in patients with remotely monitored implantable cardioverter-defibrillators: A pooled analysis of 9 clinical trials.
Heart Rhythm
October 2024
U.O. Electrophysiology, ASST Rhodense, Garbagnate Milanese (MI), Italy.
Article Synopsis
- The HeartInsight multiparametric algorithm uses remote monitoring data from implantable cardioverter-defibrillators (ICDs) to calculate an HF Score, which helps predict worsening heart failure hospitalizations (WHFHs).
- A study pooled data from 9 clinical trials involving 1,841 ICD patients, finding that a high baseline HF Score significantly correlates with increased long-term risks of death and WHFHs.
- The analysis revealed that patients with an HF Score over 23 faced more than double the risk of experiencing death or WHFH compared to those with lower scores, emphasizing the score's potential in risk stratification for heart failure patients.
Dual antiplatelet therapy duration and stent type in patients with high bleeding risk: A systematic review and network meta-analysis.
Am Heart J
January 2025
Division of Cardiovascular Medicine, New York University Grossman School of Medicine, New York, NY.
Article Synopsis
- - The study investigates the effectiveness and safety of dual antiplatelet therapy (DAPT) in high bleeding risk (HBR) patients, focusing on how these factors are influenced by DAPT duration and different stent types.
- - A network meta-analysis of 13 randomized controlled trials involving nearly 19,500 HBR patients found that short DAPT with durable polymer drug-eluting stents (DP-DES) is associated with lower bleeding risks while still maintaining efficacy compared to standard DAPT.
- - The research concludes that for HBR patients undergoing coronary interventions, using a short DAPT strategy with DP-DES strikes the best balance between minimizing bleeding risks and preventing adverse cardiovascular events.
Gender Disparities in Japanese Interventional Cardiology: Outcomes of Female Operators in Percutaneous Coronary Interventions.
JACC Asia
September 2024
Department of Cardiology, Teikyo University Hospital, Tokyo, Japan.
Article Synopsis
- The study investigates gender disparity in interventional cardiology, focusing on the outcomes of percutaneous coronary interventions (PCIs) performed by female interventionalists in Japan.
- A total of 447 female operators conducted 35,211 PCIs during the study, showing that female doctors treated more patients with severe heart conditions but had a higher overall success rate than male doctors.
- Results indicate that female operators had similar in-hospital mortality rates compared to male operators, but the findings highlight the need for increased gender diversity in the field.
Transcatheter Aortic Valve Implantation in Japanese Patients With Large Annulus: The OCEAN-TAVI Registry.
JACC Asia
September 2024
Division of Cardiology, Keio University School of Medicine, Tokyo, Japan.
Article Synopsis
- East Asians typically have smaller aortic valve complexes compared to Western populations, and there’s limited data on TAVI outcomes in Asian patients with large annuli.
- This study analyzes TAVI results in Asian patients, comparing outcomes between balloon-expandable valves (BEVs) and self-expandable valves (SEVs) by examining data from the OCEAN-TAVI registry.
- Findings show no significant differences in 3-year all-cause mortality, heart failure rehospitalization rates, or valve function after 2 years between BEV and SEV groups, although SEVs had higher rates of paravalvular leakage and pacemaker implantation.
Article Synopsis
- * Recent efforts to stop smoking haven't been put into action yet, and it’s important to see what could happen if smoking rates stay the same or improve.
- * Researchers used models to predict health outcomes by 2050 based on different scenarios of smoking rates, showing that cutting smoking could greatly improve health and life expectancy.
In vivo assessment of catheter-tissue contact using tissue proximity indication and its impact on cardiac lesion formation in pulsed field ablation.
Heart Rhythm
October 2024
Biosense Webster Inc, Irvine, California.
Article Synopsis
- - The study explored how tissue proximity indication (TPI), which assesses catheter contact with tissue, affects the success of lesion formation during pulsed field ablation (PFA) in live porcine models.
- - Researchers compared lesions formed under different contact conditions (no/minimum vs. consistent contact) and found that consistent contact resulted in significantly larger and more effective lesions, with greater transmurality.
- - The results highlight that a reliable TPI signal is crucial for achieving optimal lesion characteristics, suggesting that maintaining good tissue contact can enhance the outcomes of PFA procedures.
Whole-exome sequencing reveals the genetic causes and modifiers of moyamoya syndrome.
Sci Rep
October 2024
Institute for Comprehensive Medical Sciences, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
Article Synopsis
- Moyamoya syndrome (MMS) is linked to genetic disorders and arises from a mix of genetic mutations and modifiers, with a focus on whole-exome sequencing (WES) to identify these connections.
- In a study of 13 patients, WES identified genetic conditions like neurofibromatosis type 1, Down syndrome, and others, confirming previously known modifier genes in some cases.
- The research suggests that rare genetic variants associated with both MMS and conditions like pulmonary arterial hypertension could serve as new diagnostic tools and potential treatments in the future.
Key challenges in prehospital and emergency care in Indonesia and Malaysia: a survey of frontline clinicians.
BMC Res Notes
October 2024
Academic Unit Trauma and Emergency, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Rapid economic growth in Indonesia and Malaysia has widened the gap in emergency care supply and demand, intensifying challenges. Our study, from August to November 2022, assesses current diverse challenges in both countries' emergency care systems from frontline staff perspectives. The online survey involved emergency department (ED) personnel from 11 hospitals in Indonesia and Malaysia, drawing from an existing network.
View Article and Find Full Text PDFAnnual change in eGFR in renal hypouricemia: a retrospective pilot study.
Clin Exp Nephrol
October 2024
Department of Cardiology, National Hospital Organization, Yonago Medical Center, Yonago, Japan.
Article Synopsis
- Some people with a condition called renal hypouricemia (RHU) have very low levels of uric acid, which might be linked to kidney problems, but we don’t know much about how it affects kidney function.
- A study looked at 13 RHU patients over about 5.5 years and found that their kidney function (eGFR) didn't get worse, while it did for others without RHU.
- RHU patients with different types of genetic mutations also showed no major differences in how their kidney function changed over time.
Background: Implantable cardioverter defibrillators (ICDs) reduce mortality associated with ventricular arrhythmia in high-risk patients with cardiovascular disease. Machine learning (ML) approaches are promising tools in arrhythmia research; however, their application in predicting ventricular arrhythmias in patients with ICDs remains unexplored. We aimed to predict and stratify ventricular arrhythmias requiring ICD therapy using 12-lead electrocardiograms (ECGs) in patients with an ICD.
View Article and Find Full Text PDFThe role of advanced physiological guidance in contemporary coronary artery disease management.
Curr Opin Cardiol
November 2024
Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium.
Article Synopsis
- The review discusses the pullback pressure gradient (PPG) as a new metric for evaluating coronary artery disease (CAD) and its role in improving clinical decisions related to percutaneous coronary interventions (PCIs).
- Recent studies show a strong link between PPG values and post-PCI outcomes, indicating that higher PPG correlates with better patient results and helps identify at-risk plaque types.
- PPG has the potential to become a standard tool in CAD management, guiding treatment plans and enhancing patient care, though further research is needed to establish specific thresholds and optimize its use.
Pulmonary complex infection with vascular Ehlers-Danlos syndrome: A case report.
Respir Med Case Rep
September 2024
Department of Respiratory Medicine, Nippon Medical School Hospital, Tokyo, Japan.
Article Synopsis
- A female patient experienced multiple intestinal perforations in her thirties and, after being evaluated at age 52, was diagnosed with vascular Ehlers-Danlos syndrome (vEDS) due to her family history of related conditions.
- Following her diagnosis, she developed severe vascular issues, including external iliac artery dissection, along with lung complications that were identified via a CT scan.
- The patient also suffered from a rare type of pulmonary disease (MAC), which was treated successfully with antibiotics, leading to improvement in her respiratory symptoms.
Furosemide for patent ductus arteriosus during cyclooxygenase inhibitor therapy: A systematic review.
Pediatr Int
September 2024
Department of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan.
Background: Although furosemide is used during cyclooxygenase (COX) inhibitor therapy for patent ductus arteriosus (PDA), there are concerns regarding increased ductal closure failure and acute renal failure (ARF). This systematic review explores the effects of furosemide during COX inhibitor therapy.
Methods: We searched MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature, Cochrane Central Register of Controlled Trials, and Igaku Chuo Zasshi databases for randomized clinical trials that assessed furosemide during COX inhibitor therapy for PDA in preterm infants.
Coronary artery calcification and cardiovascular outcome as assessed by intravascular OCT and artificial intelligence.
Biomed Opt Express
August 2024
School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China.
Article Synopsis
- The study investigates coronary artery calcification (CAC) as a significant indicator of atherosclerosis and its link to clinical outcomes, highlighting the need for better imaging analysis methods.* -
- Researchers developed a deep learning technique to automatically identify and measure CAC using a large dataset of over 1 million OCT images from 1,048 patients, achieving nearly human-level accuracy in their assessments.* -
- Analysis of 1,259 patients with ST-segment elevated myocardial infarctions showed that those with more severe calcification in the affected arteries faced a higher risk of major cardiovascular and cerebrovascular events, while calcification in other arteries was not significantly linked to these risks.*
BEEAF Score: A New Risk Stratification Score for Patients With Stage B Heart Failure From the KUNIUMI Registry Chronic Cohort.
J Am Heart Assoc
October 2024
Division of Cardiovascular Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine Kobe Japan.
Article Synopsis
- Stage B heart failure (HF) involves structural heart disease without symptoms, and identifying risk in these patients is complex but crucial for early intervention.
- A study of 1,646 heart failure patients established a scoring system called BEEAF to categorize stage B HF patients into low, moderate, and high-risk groups based on specific health indicators.
- The results indicated that higher risk levels predicted worse outcomes, with high-risk stage B patients faring similarly to those in stage C HF.
Article Synopsis
- The simplified Pulmonary Embolism Severity Index (sPESI) score helps identify low-risk patients for home treatment of pulmonary embolism, but its use with direct oral anticoagulants hasn't been thoroughly studied.
- A study of 2,496 patients with stable pulmonary embolism found that only 25% had an sPESI score of 0, and among those, only 17% were treated at home, though their 30-day mortality was notably low (0% vs. 4.8% in higher risk groups).
- Factors promoting home treatment included the absence of temporary risk factors, no elevated cardiac biomarkers, and the use of direct oral anticoagulants during the acute phase.
JCS/JCC/JSPCCS 2024 Guideline on Genetic Testing and Counseling in Cardiovascular Disease.
Circ J
November 2024
Genome Medical Science Project, National Center for Global Health and Medicine.
Exploratory Online Survey Regarding Perceptions of Health Inequities Influenced by Social Determinants of Health Among Cardiovascular Disease Patients.
Int Heart J
September 2024
Department of Cardiovascular Medicine, St. Luke's International Hospital.
Article Synopsis
- - The study aimed to identify social determinants of health (SDOH) that contribute to health inequities experienced by Japanese patients with cardiovascular diseases (CVD).
- - An online survey of 2,083 CVD patients revealed high agreement on seven key SDOH factors, including employment, food insecurity, and poverty, which were linked to perceived health inequities.
- - Factors such as younger age, higher income, and education levels were associated with a greater perception of these health inequities, indicating that similar SDOH issues seen in Western countries also affect Japanese CVD patients.
Three-Dimensional Geometry Values and Clinical Determinants for the Annulus of the Tricuspid Valve in a Japanese Population.
Int Heart J
September 2024
Department of Clinical Laboratory, The University of Tokyo Hospital.
Article Synopsis
- The study focuses on establishing reference values for the tricuspid annulus (TA) geometry in a Japanese population, which is important for tricuspid valve surgery related to tricuspid regurgitation (TR).
- Using 3D echocardiography, researchers analyzed data from 96 healthy Japanese subjects and found that TA area and circumference strongly correlate with body surface area, while age has a weaker correlation.
- Gender differences in TA geometry were significant in younger subjects, with males showing larger TA area and smaller diameters compared to females, but these differences lessened with age.
Head-to-head comparison of F-sodium fluoride coronary PET imaging between a silicon photomultiplier with digital photon counting and conventional scanners.
J Nucl Cardiol
December 2024
Department of Medicine, Division of Artificial Intelligence in Medicine, Imaging, and Biomedical Science, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address:
Article Synopsis
- The study compared the effectiveness of silicone photomultipliers (SiPM) and traditional photomultiplier tubes (PMT) in PET imaging for coronary plaque activity using F-sodium fluoride (F-NaF).
- Conducted with 25 cardiovascular patients, the research measured image noise, signal-to-noise ratio (SNR), and target-to-background ratio (TBR) using both PET systems.
- Results demonstrated that SiPM PET provided clearer images with significantly lower noise levels and higher SNR and TBR compared to PMT PET, indicating better performance for coronary imaging.
High plasma levels of fortilin are associated with cardiovascular events in patients undergoing coronary angiography.
Heart Vessels
September 2024
Department of Cardiology, NHO Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo, 152-8902, Japan.
Article Synopsis
- Excessive apoptosis and inadequate clearance of dying cells are key features of atherosclerotic plaques, which are linked to heart disease.
- Fortilin, an antiapoptotic protein found in high levels in these plaques, was studied in 404 patients undergoing coronary angiography to assess its link to major adverse cardiovascular events (MACE).
- Results showed that higher plasma fortilin levels (specifically >80.0 pg/mL) were associated with a higher risk of MACE and were significant predictors of adverse cardiovascular outcomes, particularly in patients with coronary artery disease (CAD).
Association between complementary use of Goreisan (a Japanese herbal Kampo medicine) and heart failure readmission: A nationwide propensity score-matched study.
J Cardiol
September 2024
Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan.
Article Synopsis
- Goreisan, a Japanese herbal medicine, is thought to help regulate body fluids and may improve heart failure (HF) treatment outcomes, but its effectiveness alongside standard medications was evaluated in this study.
- The study analyzed over 431,000 patients treated for HF and compared one-year readmission rates between those taking Goreisan with their standard medications and those only receiving standard treatments.
- Results showed no significant difference in readmission rates overall, although patients with renal disease showed a lower risk of readmission when taking Goreisan, indicating it may be beneficial for that specific group.
The association between introduction of the micro-axial flow pump Impella in hospitals and in-hospital mortality in patients treated with extracorporeal membrane oxygenation: interrupted time-series analyses.
Ann Intensive Care
September 2024
Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 1130033, Japan.
Background: The micro-axial flow pump Impella, a new mechanical circulatory device for cardiogenic shock, is still only available in a limited number of hospitals, due to the facility certification requirements and insufficient evidence of the benefit of introducing Impella in hospitals. This study aimed to evaluate the impact of introducing Impella in hospitals on in-hospital mortality of patients treated with extracorporeal membrane oxygenation (ECMO).
Methods: Using a nationwide Japanese inpatient database, we identified patients who received ECMO during hospitalization between 1 April 2014 and 31 March 2021.