6,753 results match your criteria: "Department of Cardiology Tokyo Medical & Dental University Tokyo Japan.[Affiliation]"

The effect of self-measurement of blood pressure (BP) at home (home BP measurement, HBPM) has been evaluated over the past decade. This meta-analysis included the latest studies to determine whether HBPM reduced BP (PROSPERO ID: CRD42023442225). PubMed, Cochrane Library Database, and IchuShi-Web were searched for randomized controlled trials after the year 2000 which demonstrated the effect of HBPM on BP change compared with usual care (UC).

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Background: Hospital-associated disability (HAD), a decline in the ability to perform activities of daily living (ADL) during hospitalization, is a modifiable target in integrated care for older adults. The aim of this study was to determine the impact of inpatient cardiac rehabilitation (CR) on the development of HAD in older patients with aortic stenosis undergoing transcatheter aortic valve implantation (TAVI).

Methods: Older patients undergoing TAVI were extracted from the Japanese nationwide database (JROAD-DPC) from April 2014 to March 2021 and were divided into patients receiving inpatient CR (CR group) and a non-CR group.

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  • - The study investigates the metabolic profiles of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) after their transplantation, showing that these grafts mature from relying on glycolysis to utilizing fatty acid oxidation over time.
  • - Researchers also explored teratomas, which can arise from non-cardiomyocyte cells within transplanted hiPSCs, finding elevated amino acid transporters and accumulation of specific amino acids like methionine in these tumors.
  • - The presence of subcutaneous teratomas from undifferentiated hiPSCs can be detected through positron emission tomography using a specific tracer, highlighting its relevance in assessing the safety of cardiac regenerative therapies.
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  • This study explores the relationship between handgrip strength and all-cause mortality in patients undergoing transcatheter edge-to-edge repair (TEER) for heart issues, suggesting that weaker grip strength could indicate a higher risk of death post-procedure.
  • It includes data from the OCEAN-Mitral Registry, which analyzed handgrip tests of 2077 patients before TEER, with follow-ups showing varied changes in strength based on the success of the procedure.
  • The findings suggest that improving mitral regurgitation (MR) post-TEER can positively impact frailty and resilience, making this research a significant insight into patient outcomes in heart-related treatments.
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Calcified nodule (CN) is a high-risk phenotype of coronary artery calcification that causes in-stent restenosis frequently. Stent thrombosis (ST) is a critical complication following percutaneous coronary intervention, and its onset is associated with severely calcified lesions. However, the association between CN and ST remains unclear.

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Background: Becker muscular dystrophy (BMD) is a dystrophinopathy caused by a pathological variant of the DMD gene. Urinary titin, a degradation product of the giant protein titin present in muscle sarcomeres, has been used as a biomarker to reflect muscle degradation in Duchenne muscular dystrophy, a more severe dystrophinopathy. However, the clinical significance of urinary titin levels in BMD remains unclear.

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Background: Statins bring favourable effects on the clinical prognosis of patients with atherosclerotic disease partly through their anti-inflammatory properties. However, this effect has not been fully verified in patients with peripheral arterial disease (PAD). We aimed to test whether statins exert different prognostic effects depending on the degrees of inflammation in patients with PAD.

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Patients hospitalized for heart failure (HF) experience impairments in functional status, primarily affecting basic activities of daily living (ADL). We investigated the independent effect of functional status for ADL on patient-centered outcomes (i.e.

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  • The study compares two treatment methods for patients with tricuspid regurgitation: tricuspid transcatheter edge-to-edge repair (T-TEER) and surgical tricuspid valve repair, focusing on outcomes like two-year all-cause mortality and other complications.
  • Analysis was conducted on 1,143 Medicare beneficiaries aged 65 to 99, revealing no significant difference in two-year mortality rates between the two treatments, but noted a rise in T-TEER procedures over the years.
  • T-TEER showed lower in-hospital mortality and fewer cases requiring pacemaker implantation, but more tricuspid valve reinterventions were needed compared to surgical repair, indicating a need for further research on treatment selection and timing
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Background: The optimal duration of anticoagulation therapy for patients with cancer and acute low-risk pulmonary embolism (PE) is clinically relevant, but evidence is lacking. Prolonged anticoagulation therapy could have a potential benefit for prevention of thrombotic events; however, it could also increase the risk of bleeding.

Methods: In a multicenter, open-label, adjudicator-blinded, randomized clinical trial at 32 institutions in Japan, we randomly assigned patients with cancer and acute low-risk PE of the simplified version of the Pulmonary Embolism Severity Index score of 1, in a 1:1 ratio, to receive either an 18-month or a 6-month rivaroxaban treatment.

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In this narrative review, we summarized evidence from peer-reviewed articles, published before February 2024, that investigated lifestyle behaviors among children (≤12 years) and adolescents (13-18 years) representing different geographic descents. These behaviors included dietary patterns, screen time, physical activity, smoking, alcohol consumption, oral hygiene, unsafe sex, and sleep duration and quality. We documented the significant impacts of parental, school, and sociodemographic factors on the adoption of numerous lifestyle behaviors in this age category.

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Background: Redo-transcatheter aortic valve implantation (TAVI) may be unfeasible because of the risk of compromising coronary flow or coronary access by the pinned back leaflets of the index transcatheter aortic valve.

Aims: We aimed to evaluate the feasibility of redo-TAVI using the balloon-expandable SAPIEN 3 (S3) implanted within the self-expanding ACURATE neo2 (ACn2) valve and to identify predictors associated with a high risk of compromising coronary flow.

Methods: A total of 153 post-ACn2 TAVI cardiac computed tomography scans were analysed.

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  • This study examined how left ventricular ejection fraction (LVEF) changes after a specific heart valve repair procedure called transcatheter edge-to-edge valve repair (TEER) in patients with mitral regurgitation (MR).
  • Findings revealed that 32% of patients experienced worsened LVEF after the procedure, linked to increased end-systolic volumes in the heart and certain predictors like higher LVEF and levels of B-type natriuretic peptide.
  • Despite the LVEF worsening, long-term outcomes (like death or hospitalization for heart failure) were similar for both patients with worsened and preserved LVEF, indicating that LVEF change might not significantly impact overall health results post-TEER
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Coronary flow capacity (CFC) integrates quantitative assessment of hyperemic myocardial blood flow and coronary flow reserve. We aimed to evaluate the effect of elective percutaneous coronary revascularization (PCI) on CFC using serial stress transthoracic Doppler echocardiography (STDE). Overall, 148 stable patients underwent STDE of the left anterior descending arteries (LAD), before and after elective PCI.

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  • The study examines the use and outcomes of P2Y inhibitor pretreatment in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) in the U.S. from 2013 to 2023.
  • P2Y inhibitor pretreatment rates decreased significantly from 24.8% to 12.4% over the study period, with only 15.9% in a recent cohort showing such treatment.
  • There was notable variability in pretreatment rates among different operators and institutions, with no significant difference in in-hospital mortality between those who received pretreatment and those who did not.
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  • Older patients with heart failure (HF) experience a higher risk of developing pneumonia, which contributes to increased mortality rates.
  • A study of 1,266 hospitalized patients aged 65 and older found that those with low muscle strength were significantly more likely to develop pneumonia post-discharge.
  • Low muscle strength was identified as a strong predictor of pneumonia and associated with a fourfold increased risk of death after pneumonia onset.
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Case report: a case of masked subclavian artery stenosis in a haemodialysis patient.

Eur Heart J Case Rep

November 2024

Department of Cardiology, Tokyo Medical University, 6-7-1 Nishishinjyuku, Shinjyuku-ku, 160-0023 Tokyo, Japan.

Background: Subclavian artery stenosis is generally screened by a left-right brachial systolic blood pressure difference. However, subclavian artery stenoses are often underdiagnosed due to marginally identified symptoms. In dialysis patients, a relative or absolute contradiction of measuring blood pressure in shunt brachial artery may further limit the disease screening.

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Prognostic Value of Sarcopenia Definitions and Outcomes Consortium Criteria in Older Patients with Heart Failure.

J Am Med Dir Assoc

January 2025

Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Japan Agency for Medical Research and Development-Core Research for Evolutionary Medical Science and Technology (AMED-CREST), Tokyo, Japan.

Objectives: The Asian Working Group for Sarcopenia in 2019 (AWGS 2019) emphasized muscle mass measurements. In contrast, the Sarcopenia Definitions and Outcomes Consortium (SDOC) prioritizes functional strength and mobility. Therefore, this study aimed to compare the prognostic utility of the SDOC and AWGS 2019 criteria for all-cause mortality in older patients with heart failure.

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Unlabelled: Loeys-Dietz syndrome (LDS) type 4 is a rare connective tissue disorder caused by mutations in the transforming growth factor β 2 gene. It is well-documented that LDS4 shares clinical features of Marfan syndrome (MFS), and vascular involvement is less significant compared to other types of LDS. However, information on the valvular characteristics is scarce due to the small number of reported cases.

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Aims: Predictors of true degenerative mitral stenosis (MS) in patients with aortic stenosis who underwent transcatheter aortic valve implantation (TAVI) remain unknown. This study aimed to investigate the predictors and prognostic value of true degenerative MS in this population.

Methods And Results: We retrospectively reviewed the records of 760 consecutive patients who underwent TAVI.

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