2 results match your criteria: "Department of Cardiology Cardiology I University Medical Center Mainz Mainz Germany.[Affiliation]"
Objectives: Vertigo describes symptoms of abnormal movement of the environment or the patient's own body. As such, it affects patients' quality of life, prevents them from following their daily activities, and increases healthcare utilization. The Global Burden of Disease Project aims to quantify morbidity and mortality worldwide.
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- The study investigates the role of brain-derived neurotrophic factor (BDNF) in perivascular adipose tissue (PVAT) of patients with coronary atherosclerosis, highlighting its potential impact on vascular functions.
- BDNF levels were found to be significantly higher in the PVAT surrounding the proximal aorta (C-PVAT) compared to that around the internal mammary artery (IMA-PVAT), suggesting a localized effect independent of obesity or inflammation.
- The findings indicate that signaling through BDNF's receptor (TrkB) may be impaired in coronary atherosclerosis, as evidenced by reduced TrkB expression and elevated levels of a negative regulator of TrkB signaling in C-PVAT.