3 results match your criteria: "Department of Cardiology - The Second Xiangya Hospital of Central South University[Affiliation]"
Reticulon 3 regulates sphingosine-1-phosphate synthesis in endothelial cells to control blood pressure.
MedComm (2020)
February 2024
Department of Cell Biology, School of Life Sciences Central South University Changsha China.
The discovery of the endothelium as a major regulator of vascular tone triggered intense research among basic and clinical investigators to unravel the physiologic and pathophysiologic significance of this phenomenon. Sphingosine-l-phosphate (S1P), derived from the vascular endothelium, is a significant regulator of blood pressure. However, the mechanisms underlying the regulation of S1P biosynthetic pathways in arteries remain to be further clarified.
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- The study examines the relationship between low-density lipoprotein cholesterol (LDL-C) levels after coronary artery bypass grafting (CABG) and long-term health outcomes, finding that only 14.9% of patients met the LDL-C target of <1.40 mmol/L one year post-surgery.
- Among the 2072 patients analyzed, 25% experienced major adverse cardiovascular and cerebrovascular events (MACCEs) over an average follow-up of 4.2 years, with higher LDL-C levels significantly linked to an increased risk for these events.
- The findings suggest a need for better lipid management strategies post-CABG to potentially reduce long-term cardiovascular risks, prompting proposals for further studies to confirm these results