1 results match your criteria: "Department of Cancer University of Texas M. D. Anderson Cancer Center[Affiliation]"
Adenoviral-mediated expression of MMAC/PTEN inhibits proliferation and metastasis of human prostate cancer cells.
Clin Cancer Res
June 2002
Department of Cancer University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Article Synopsis
- The study aimed to explore how expressing the MMAC/PTEN gene affects the growth and survival of PC3 human prostate cancer cells.
- Introducing adenoviruses with MMAC/PTEN into PC3 cells showed that it decreased phospho Akt levels and inhibited cell growth mainly by blocking the cell cycle.
- While it did not stop tumor growth in implanted models, MMAC/PTEN significantly reduced tumor size and prevented metastasis, highlighting its potential as a therapeutic target for prostate cancer.