5 results match your criteria: "Department of Biostatistics Harvard T.H Chan School of Public Health Boston Massachusetts USA.[Affiliation]"
Article Synopsis
- High-resolution computed tomography (HRCT) is essential for diagnosing Idiopathic Pulmonary Fibrosis (IPF), but it can be confused with other interstitial lung diseases (ILDs) due to similar radiologic patterns.
- Researchers used mass spectrometry to analyze plasma extracellular vesicles (EVs) from different patient groups, identifying a five-protein signature that distinguishes IPF from other ILDs and healthy individuals.
- The study validated these biomarkers in independent cohorts, showing high accuracy but emphasizes the need for further large-scale studies to confirm their clinical application.
Introduction: The prevalence of poor sleep quality and sleep apnea differs by race and ethnicity and may contribute to racial disparities in cognitive aging. We investigated whether sleep quality and sleep apnea risk were associated with cognitive function and decline and whether the associations differed by race/ethnicity.
Methods: Participants from the Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE; = 1690; mean age: 75.
Feasibility of an online consensus approach for the diagnosis of cognitive impairment and dementia in rural South Africa.
Alzheimers Dement (Amst)
April 2023
Introduction: We describe the development and feasibility of using an online consensus approach for diagnosing cognitive impairment and dementia in rural South Africa.
Methods: Cognitive assessments, clinical evaluations, and informant interviews from Cognition and Dementia in the Health and Aging in Africa Longitudinal Study (HAALSI Dementia) were reviewed by an expert panel using a web-based platform to assign a diagnosis of cognitively normal, mild cognitive impairment (MCI), or dementia.
Results: Six hundred thirty-five participants were assigned a final diagnostic category, with 298 requiring adjudication conference calls.
Background: Understanding venous thromboembolism (VTE) recurrence risk is central to determining the appropriate treatment course. Whether this risk varies after discontinuing anticoagulation or overall by type of incident event (pulmonary embolism [PE] vs deep vein thrombosis [DVT]) and by the detailed location of the DVT needs further clarification.
Methods: In this population-based inception cohort of incident VTE cases with follow-up by electronic health record review, incident DVT was categorized as distal, popliteal, or iliofemoral.
Introduction: Blood metabolomics-based biomarkers may be useful to predict measures of neurocognitive aging.
Methods: We tested the association between 707 blood metabolites measured in 1451 participants from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), with mild cognitive impairment (MCI) and global cognitive change assessed 7 years later. We further used Lasso penalized regression to construct a metabolomics risk score (MRS) that predicts MCI, potentially identifying a different set of metabolites than those discovered in individual-metabolite analysis.