2 results match your criteria: "Department of Biomolecular Medicine Ghent University Ghent Belgium.[Affiliation]"
overexpression synergizes with the loss of and is a dependency factor and therapeutic target in T-cell lymphoblastic leukemia.
Hemasphere
March 2024
Normal and Malignant Hematopoiesis Lab, Department of Biomolecular Medicine Ghent University Ghent Belgium.
Article Synopsis
- T-lineage acute lymphoblastic leukemia (T-ALL) is a serious type of cancer that affects a significant percentage of children and adults, with poor outcomes for those who relapse or resist treatment.
- Understanding the role of the proto-oncogene MYB is crucial as it is linked to increased T-ALL aggression and worse patient survival, particularly in pediatric cases.
- This study reveals that high MYB levels drive T-ALL development and that targeting MYB's function could offer a promising new treatment approach.
Separating extracellular vesicles (EV) from blood plasma is challenging and complicates their biological understanding and biomarker development. In this study, we fractionate blood plasma by combining size-exclusion chromatography (SEC) and OptiPrep density gradient centrifugation to study clinical context-dependent and time-dependent variations in the biomolecular landscape of systemically circulating EV. Using pooled blood plasma samples from breast cancer patients, we first demonstrate the technical repeatability of blood plasma fractionation.
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