2 results match your criteria: "Department of Biomedical Engineering University of Alabama at Birmingham Birmingham AL USA.[Affiliation]"
Background: The proliferative capacity of cardiomyocytes in adult mammalian hearts is far too low to replace the cells that are lost to myocardial infarction. Both cardiomyocyte proliferation and myocardial regeneration can be improved via the overexpression of a constitutively active variant of YAP5SA (Yes-associated protein, 5SA [active] mutant), but persistent overexpression of proliferation-inducing genes could lead to hypertrophy and arrhythmia, whereas off-target expression in fibroblasts and macrophages could increase fibrosis and inflammation.
Methods And Results: Transient overexpression of YAP5SA or GFP (green fluorescent protein; control) was targeted to cardiomyocytes via our cardiomyocyte-specific modified mRNA translation system (CM-SMRTs or CM-SMRTs, respectively).
Article Synopsis
- * A case study is presented involving a 62-year-old man with immune-mediated TTP (iTTP) that developed over three years, including symptoms like low platelet count, recurrent strokes, and valve clots.
- * The report suggests a potential link between the use of adalimumab, a TNFα inhibitor, and the onset of iTTP, while also highlighting the need to recognize atypical manifestations of the disease due to its complex history and comorbid health issues in the patient.