Binary mixtures of imidacloprid and thiamethoxam do not appear to cause additive toxicity in fathead minnow larvae ().

Considerable use of neonicotinoid insecticides has resulted in their detection in surface waters globally, with imidacloprid (IM) and thiamethoxam (TM) frequently found together. Neonicotinoids are selective agonists for invertebrate nicotinic acetylcholine receptors (nAChR) leading to paralysis and death. While not overtly toxic to vertebrates, growing evidence suggests that chronic exposure to individual neonicotinoids can cause adverse health effects in fish.

Relation among Mercury, Selenium, and Biomarkers of Oxidative Stress in Northern Pike ().

Mercury (Hg) is a toxic environmental contaminant associated with oxidative stress in freshwater fish. A known antagonist to Hg, selenium (Se), may reduce the toxic effects of Hg. In this study, the relation among Se, methylmercury (MeHg), inorganic mercury (IHg), total mercury (THg), and the expression of biomarkers of oxidative stress and metal regulation in livers of northern pike were examined.

Larval exposure to environmentally relevant concentrations of triclosan impairs metamorphosis and reproductive fitness in zebrafish.

Developmental exposure to endocrine disruptors can cause organizational changes resulting in latent and transgenerational disease. We exposed zebrafish to environmentally relevant concentrations of triclosan during the critical period of metamorphosis and somatic sex differentiation to determine effects on metamorphosis and reproduction. We use biological and morphological biomarkers to predict potential modes of action.

Embryonic exposure to environmentally relevant concentrations of triclosan impairs foraging efficiency in zebrafish larvae.

The ubiquitous and persistent contaminant triclosan is known to cause developmental and behavioral toxicity in fish, but few studies have evaluated the long-term effects of these responses. We used a phenotypically anchored approach to evaluate the behavioral responses caused by early exposure to environmentally relevant concentrations of triclosan to better understand the risk triclosan poses to fish. Zebrafish were exposed to 0, 0.

Relationship among mercury concentration, growth rate, and condition of northern pike: A tautology resolved?

Methylmercury is a bioaccumulative contaminant that biomagnifies in aquatic food webs and adversely affects the health of freshwater fish. Previous studies have documented an inverse relationship between fish condition and concentration of mercury in fish. However, this relationship may be a result of slow-growing fish accumulating large amounts of methylmercury rather than the effects of methylmercury on fish condition and growth.

Dioxin induction of transgenerational inheritance of disease in zebrafish.

Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD) is an aryl hydrocarbon receptor (AHR) agonist, an endocrine disruptor, and a potent global pollutant. TCDD exposure is associated with diseases of almost every organ system, and its toxicity is highly conserved across vertebrates. While the acute developmental effects of dioxin exposure have been extensively studied, the ability of early sublethal exposure to produce toxicity in adulthood or subsequent generations is poorly understood.

Reproductive and developmental toxicity of dioxin in fish.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD or dioxin) is a global environmental contaminant and the prototypical ligand for investigating aryl hydrocarbon receptor (AHR)-mediated toxicity. Environmental exposure to TCDD results in developmental and reproductive toxicity in fish, birds and mammals. To resolve the ecotoxicological relevance and human health risks posed by exposure to dioxin-like AHR agonists, a vertebrate model is needed that allows for toxicity studies at various levels of biological organization, assesses adverse reproductive and developmental effects and establishes appropriate integrative correlations between different levels of effects.