5 results match your criteria: "Department of Anesthesiology and Cardiovascular Research Center[Affiliation]"
Vascular regression in the kidney: changes in 3D vessel structure with time post-irradiation.
Biomed Opt Express
August 2022
Department of Electrical Engineering and Computer Science at Florida Atlantic University, Boca Raton, FL 33431, USA.
Article Synopsis
- Vascular regression in the kidneys leads to significant changes in blood vessel volume and density, particularly 90 days after a single dose of radiation.
- This regression is marked by substantial reductions in total vessel volume (55%), vessel density (57%), and other key metrics.
- The study suggests that vascular changes occur in a manner specific to each organ, with notable effects seen in both small and large blood vessels post-irradiation.
Optical Metabolic Imaging for Assessment of Radiation-Induced Injury to Rat Kidney and Mitigation by Lisinopril.
Ann Biomed Eng
July 2019
Department of Electrical Engineering, Biophotonics Lab, University of Wisconsin Milwaukee, Milwaukee, WI, USA.
The kidney is one of the most radiosensitive organs; it is the primary dose-limiting organ in radiotherapies for upper abdominal cancers. The role of mitochondrial redox state in the development and treatment of renal radiation injury, however, remains ill-defined. This study utilizes 3D optical cryo-imaging to quantify renal mitochondrial bioenergetics dysfunction after 13 Gy leg-out partial body irradiation (PBI).
View Article and Find Full Text PDFOptical metabolic imaging of irradiated rat heart exposed to ischemia-reperfusion injury.
J Biomed Opt
January 2018
Medical College of Wisconsin, Department of Anesthesiology and Cardiovascular Research Center, Milwa, United States.
Whole thoracic irradiation (WTI) is known to cause deterioration in cardiac function. Whether irradiation predisposes the heart to further ischemia and reperfusion (IR) injury is not well known. The aim of this study is to examine the susceptibility of rat hearts to IR injury following a single fraction of 15 Gy WTI and to investigate the role of mitochondrial metabolism in the differential susceptibility to IR injury.
View Article and Find Full Text PDFMitochondria: hubs of cellular signaling, energetics and redox balance. A rich, vibrant, and diverse landscape of mitochondrial research.
Front Physiol
April 2015
Department of Anesthesiology and Cardiovascular Research Center, Medical College of Wisconsin Milwaukee, WI, USA.
Central AT1 and AT2 receptors mediate chronic intracerebroventricular angiotensin II-induced drinking in rats fed high sodium chloride diet from weaning.
Acta Physiol Scand
February 2001
Department of Anesthesiology and Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
Intracerebroventricular (ICV) angiotensin (AIl) administration stimulates central AII receptors to induce water consumption in rats. The aim of this study was to determine the role of brain AT1 and AT2 receptors in mediating chronic ICV AII-induced drinking in rats raised on normal or high sodium chloride diets from weaning. Rats were weaned at 21 days of age and placed on normal or high sodium chloride diet for 10-12 weeks.
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