Closed cranial window rodent model for investigating hemodynamic response to elevated intracranial pressure.

Background: Elevated intracranial pressure (ICP) occurs in several physiological and pathological conditions, yet long-term sequellae are not common, which implies that blood flow is preserved above ischemic thresholds.

Methods: This pilot study sought to confirm this hypothesis using a closed cranial window model in a rat in which ICP was elevated to 120 mmHg for 12 min, and superficial cortical perfusion was measured by laser Doppler flowmetry and laser speckle flowmetry.

Results: Following a transient increase, cortical blood flow decreased to between 25% and 75% of baseline.