The phosphodiesterase-4 inhibitor Ro 20-1724 reverses learning and memory impairments, and downregulation of CREB in the hippocampus and cortex induced by ketamine anesthesia in immature rats.

Aim: The objective of the study was to examine the effects and possible mechanisms of phosphodiesterase-4 inhibitor Ro 20-1724 on learning and memory impairments induced by ketamine anesthesia. Further, expression the cAMP response element binding proteins (CREB), transcription factors involved in long-term memory, were analyzed in conjunction with these effects of Ro 20-1724.

Methods: Ninety-six immature (21-day-old) Sprague-Dawley rats were divided into eight groups.