5 results match your criteria: "Department of Advanced Cardiovascular Therapeutics Nagoya University Graduate School of Medicine Nagoya Japan.[Affiliation]"
Article Synopsis
- Hydrogen sulfide (HS) plays a significant role in cardiovascular health, but its impact on lymphatic vessel growth and lymphedema resolution is not well understood, prompting this study.
- Researchers created a mouse model to assess lymphedema and found that mice lacking cystathionine γ-lyase had worse lymphedema and reduced lymphatic vessel repair compared to wild-type mice.
- Treatment with an HS donor improved lymphatic vessel formation and decreased lymphedema symptoms by activating the Akt signaling pathway in lymphatic endothelial cells, suggesting HS could be a therapeutic option for treating lymphedema.
Background Circadian rhythm disorders, often seen in modern lifestyles, are a major social health concern. The aim of this study was to examine whether circadian rhythm disorders would influence angiogenesis and blood perfusion recovery in a mouse model of hind limb ischemia. Methods and Results A jet-lag model was established in C57BL/6J mice using a light-controlled isolation box.
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- His bundle pacing (HBP) is a new technique aimed at improving heart function by stimulating the natural His-Purkinje system, but its best uses and long-term effects are still unclear.
- A multicenter study in Japan is following patients with atrioventricular block who undergo HBP, tracking outcomes such as overall death, hospitalizations for heart failure, and changes in heart function over three years.
- The study aims to gather substantial data to better understand the safety and efficacy of HBP, potentially providing key insights for future patient management and treatment strategies.