Angiotensin II type 1 receptor blocker telmisartan induces apoptosis and autophagy in adult T-cell leukemia cells.

Adult T-cell leukemia/lymphoma (ATL), an aggressive T-cell malignancy that develops after long-term infection with human T-cell leukemia virus (HTLV-1), requires new treatments. Drug repositioning, reuse of a drug previously approved for the treatment of another condition to treat ATL, offers the possibility of reduced time and risk. Among clinically available angiotensin II receptor blockers, telmisartan is well known for its unique ability to activate peroxisome proliferator-activated receptor-γ, which plays various roles in lipid metabolism, cellular differentiation, and apoptosis.

Three-dimensional analysis of tooth movements after palatal miniscrew-supported molar distalization.

Introduction: The aim of this prospective clinical study was to evaluate the dentoalveolar effects of a palatal miniscrew-supported molar distalization appliance using a 3-dimensional reverse engineering method.

Methods: This study sample comprised 21 patients at an average age of 13.6 years with a bilateral Class II molar relationship.

Increased visfatin expression is associated with nuclear factor-kappa B and phosphatidylinositol 3-kinase in periodontal inflammation.

Objective: Visfatin is an adipocytokine that plays a role in regulating periodontal inflammation by as yet identified mechanisms. It has been suggested that visfatin mediates inflammation via activation of the nuclear factor-kappa B (NF-κB) and phosphatidylinositol 3-kinase (PI3k) signaling pathways which play a role in the inhibition of neutrophil apoptosis. The aim of this study was to investigate the expression of visfatin, NF-κB (NF-κB and NF-κB), PI3k, tumor necrosis factor alpha (TNF-α), and interleukin-1 beta (IL-1β) in the tissue of healthy individuals and patients with periodontitis.

Effects of rapid maxillary expansion on facial soft tissues : Deviation analysis on three-dimensional images.

Objective: Changes in soft tissue in various morphological regions of the face immediately after rapid maxillary expansion (RME) were examined using three-dimensional (3D) deviation analyses.

Patients And Methods: A total of 50 patients were included in the study; 25 patients (11 female and 14 male) presented with a unilateral or bilateral posterior crossbite malocclusion requiring RME. In addition, 25 patients (13 female and 12 male) were included as a control group.

Reproducibility of the lip position at rest: A 3-dimensional perspective.

Introduction: In this study, we evaluated the reproducibility of the lip position at rest in 3 dimensions using reverse engineering software and stereophotogrammetric images.

Methods: We used 3dMD Flex (3dMD, Atlanta, Ga) to obtain 60 stereophotogrammetric images from the same participant. Thirty images were obtained in 3 sessions on the same day, and the procedure was repeated 6 weeks later for 30 more images.

Accuracy and reliability of 3D stereophotogrammetry: A comparison to direct anthropometry and 2D photogrammetry.

Objective: To evaluate the accuracy of three-dimensional (3D) stereophotogrammetry by comparing it with the direct anthropometry and digital photogrammetry methods. The reliability of 3D stereophotogrammetry was also examined.

Materials And Methods: Six profile and four frontal parameters were directly measured on the faces of 80 participants.

Social smile reproducibility using 3-D stereophotogrammetry and reverse engineering technology.

Objective: To assess the range of social smile reproducibility using 3-D stereophotogrammetry and reverse engineering technology.

Materials And Methods: Social smile images of white adolescents (N  =  15, mean age  =  15.4 ±1.

Comparison of low level laser and arginine-calcium carbonate alone or combination in the treatment of dentin hypersensitivity: a randomized split-mouth clinical study.

Objective: This study aimed to compare the efficacy of low-level laser (LLL) and desensitizing paste (DP) containing 8% arginine-calcium carbonate, in the treatment of dentin hypersensitivity (DH) and also to determine whether their combined application would improve the efficacy of the treatment.

Background Data: There are various options for the treatment of DH; however, superiority of one method over others alone has not been currently demonstrated.

Materials And Methods: Twenty-one patients with 156 teeth affected by DH were included in the study.

Rural Latino caregivers' beliefs and behaviors around their children's salt consumption.

Background: Prevalence of high blood pressure has been increasing in U.S. children, with implications for long term health consequences.

Evaluation of pharyngeal airway space changes after bimaxillary orthognathic surgery with a 3-dimensional simulation and modeling program.

Introduction: The aims of this study were to use 3-dimensional simulation and modeling programs to evaluate the effects of bimaxillary orthognathic surgical correction of Class III malocclusions on pharyngeal airway space volume, and to compare them with the changes in obstructive sleep apnea measurements from polysomnography.

Methods: Twenty-five male patients (mean age, 21.6 years) with mandibular prognathism were treated with bilateral sagittal split osteotomy and LeFort I advancement.

Effect of platelet rich fibrin and beta tricalcium phosphate on bone healing. A histological study in pigs.

Purpose: To investigate the effect of platelet rich fibrin (PRF) and beta tricalcium phosphate (β-TCP), alone or in combination, on bone regeneration in pig tibial defects.

Methods: Four standardized defects were prepared in both tibias of three adult male pigs. The first defect was left unfilled as a control; the others were grafted with either PRF, β-TCP or PRF mixed with β-TCP.

Changes in posterior airway space, pulmonary function and sleep quality, following bimaxillary orthognathic surgery.

Bimaxillary orthognathic surgery (BOS) is commonly used in the correction of severe Class III deformities (mandibular prognathism with maxillary retrognathism). The postural response of the pharyngeal airway after mandibular setback and maxillary advancement procedures is clinically crucial for maintaining optimum respiration. Patients might suffer from obstructive sleep apnoea, postoperatively.

Evaluation of residual antimicrobial effects and surface changes of gutta-percha disinfected with different solutions.

Aim: To determine the possible residual antibacterial effects and possible surface changes caused by 5.25% NaOCl, 2.5% NaOCl, 2% CHX and 0.

Surgical repositioning of a severely impacted mandibular second molar.

A 16-year-old girl was referred for surgical-orthodontic treatment with the chief complaint of an unerupted mandibular left second molar. With the exception of this molar, the patient had a fully erupted permanent dentition. A panoramic radiograph showed a horizontally impacted mandibular left second molar beneath a mesially impacted third molar.

Early detection of alterations in the resonance frequency assessment of oral implant stability on various bone types: a clinical study.

This study was undertaken to evaluate the relation between bone quality and alterations of implant stability quotient values measured during the initial phase of healing. Nineteen patients treated with 106 implants were included in the current study. The mean bone density of the implant recipient area was measured using Simplant 11 software incorporated in the computerized tomography (CT) machine.

Shade matching performance of normal and color vision-deficient dental professionals with standard daylight and tungsten illuminants.

Statement Of Problem: The lighting conditions of the environment and visual deficiencies such as red-green color vision deficiency affect the clinical shade matching performance of dental professionals.

Purpose: The purpose of this study was to evaluate the shade matching performance of normal and color vision-deficient dental professionals with standard daylight and tungsten illuminants.

Material And Methods: Two sets of porcelain disc replicas of 16 shade guide tabs (VITA Lumin) were manufactured to exact L*a*b* values by using a colorimeter.

Onlay iliac bone grafting as an ancillary augmentation procedure for paranasal rejuvenation during bimaxillary surgery.

Objective: The aim of this paper is to present the outcome of iliac bone block grafts used for paranasal augmentation during bimaxillary orthognathic surgery for the patient with deep concavity of canine fosse.

Study Design: Preoperative evaluation of the patient, done with 3-dimensional (3D) surgical simulation software, revealed deep bony concavity of paranasal area and insufficient soft tissue improvement when Le Fort I level maxillary advancement was accomplished. The deficient sites were grafted and better profile was achieved with 3D simulation.

Influence of different drinks on the colour stability of dental resin composites.

Objectives: The objective of this study was to evaluate the discolouration effects of artificial saliva, granule lemon juice, coffee (without sugar), coca cola, sour cherry juice, fresh carrot juice and red wine on resin-based composite materials that are commonly used in restorative dentistry.

Methods: Colour of four brands of resin composites (Filtek Z 250 (3M Espe), Filtek Supreme (3M Espe), Quadrant (Cavex), Charisma (Heraeus-Kulzer)) of A2 shade was measured after one day of immersion in eight different solutions. Colour measurements were obtained by using a XL-20 Trismus Colourimeter and colour differences (DeltaE) were estimated.

Effects of six surface treatment methods on the surface roughness of a low-fusing and an ultra low-fusing feldspathic ceramic material.

Purpose: The purpose of this in vitro study was to determine the effects of six surface treatment methods on the surface roughness of two feldspathic ceramic materials.

Materials And Methods: One hundred twenty metal discs were cast (Remanium CS). A low-fusing feldspathic ceramic (Vita Omega 900) was fired onto 60 metal discs, and an ultra low-fusing feldspathic ceramic (Finesse) was fired onto the other 60 metal discs.

Retrospective radiographic evaluation of the anterior loop of the mental nerve: comparison between panoramic radiography and spiral computerized tomography.

Purpose: This study compares the prevalence and the length of mental loops, which were measured with panoramic radiographs and spiral computerized tomographs (SCT).

Materials And Methods: Seventy-three panoramic radiographs and 73 SCTs were taken for preoperative planning of implant placement in the interforaminal region of the anterior mandible. The bone quality of both mental regions in each patient was determined by 1 experienced calibrated clinician, and the cross-sectional images of the SCTs were evaluted for bone quality according to the Lekholm and Zarb classification.

Treatment of complex dentoalveolar injury--avulsion and loss of periodontal tissue: a case report.

Dental avulsion is a common and complex injury which affects multiple oral tissues. In this case report, a 9-year-old girl patient with two traumatically avulsed maxillary central incisors with loss of periodontal tissue was presented. Treatment guidelines for avulsed permanent teeth with open apex were carried out.

A comparative in vitro study of the load at fracture of all-ceramic crowns with various thicknesses of In-Ceram core.

Aim: The aim of this study was to investigate the influence of three different thicknesses of In-Ceram core on the load at fracture of all-ceramic crowns.

Methods And Materials: Thirty standardized crown-shaped nickel-chromium alloy dies were fabricated using a milling machine. Twenty dies were prepared with a 1 mm shoulder for Groups A and B.

Effects of hyperbaric oxygen during experimental tooth movement.

Objective: To determine the effects of hyperbaric oxygen (HBO) on bone remodeling during orthodontic tooth movement.

Materials And Methods: Twenty-four male, adult Sprague Dawley rats were randomly divided into two groups. HBO was administered in the first group, and the second group served as a control.

Gold weight implantation for rehabilitation of the paralysed eyelid.

Patients with complete facial nerve palsy are at risk of severe eye complications due to corneal exposure. Gold weight implantation improves function, cosmetic appearance and morbidity. Three patients with nerve palsy underwent insertion of precisely prepared gold weights between May 2000 and December 2001.

Dynamic MRI evaluation of tongue posture and deglutitive movements in a surgically corrected open bite.

Tongue thrust usually develops in the presence of anterior open bite in order to achieve anterior valve function. In the literature, tongue thrust is described both as the result and the cause of open bite. If it is an adaptation to malocclusion, then tongue posture and deglutitive tongue movements should change after treatment.