4,997 results match your criteria: "Dental Research Institute[Affiliation]"

Automatic Reproduction of Natural Head Position in Orthognathic Surgery Using a Geometric Deep Learning Network.

Diagnostics (Basel)

December 2024

Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea.

: Accurate determination of the natural head position (NHP) is essential in orthognathic surgery for optimal surgical planning and improved patient outcomes. However, traditional methods encounter reproducibility issues and rely on external devices or patient cooperation, potentially leading to inaccuracies in the surgical plan. : To address these limitations, we developed a geometric deep learning network (NHP-Net) to automatically reproduce NHP from CT scans.

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Over the past few decades, dental implants have been successfully utilized to replace teeth lost due to periodontal disease and other conditions. However, similar to natural teeth, dental implants are vulnerable to inflammatory peri-implant diseases, which can compromise their long-term viability. This review aims to summarize the current understanding of peri-implant diseases and discuss effective strategies for their diagnosis, treatment, and long-term management.

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Background: There is limited understanding of how temporomandibular disorder (TMD) symptoms, psychological distress, and well-being are related to each other and to OHRQoL in Chinese young adults.

Objectives: This study aimed to identify correlations between TMD symptom severity, psychological status, and OHRQoL while also examining factors associated with low OHRQoL.

Methods: Participants, recruited from a major university in the capital city, completed a survey that included demographics, the Chinese versions of the expanded five TMD symptoms (5Ts) screener, Depression, Anxiety, Stress Scales-21 (DASS-21), Ryff's Scales of Psychological Well-being-18 (SPWB-18), and Oral Health Impact Profile for TMDs (OHIP-TMD).

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Limitations of Osteocutaneous Radial Flap Despite Satisfactory Outcomes in Anterior Mandible Reconstruction With Dental Implants.

J Craniofac Surg

January 2025

Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.

The management of oral malignancy necessitates a comprehensive approach focusing on disease eradication and patient quality of life. Surgery remains pivotal, although extensive resection can lead to aesthetic and functional challenges. Reconstruction, often with osteocutaneous radial forearm free flaps (OCRFFF), is crucial for restoring form and function.

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Angiogenesis is mediated by vascular endothelial growth factor (VEGF), a protein that plays a key role in wound healing, inflammatory diseases, cardiovascular processes, ocular diseases, and tumor growth. Indeed, modulation of angiogenesis represents a potential approach to treating cancer and, as such, therapeutic approaches targeting VEGF and its receptors have been widely investigated as part of the broader search for curative interventions. Equally, RNA interference is a powerful tool for treating diseases, but its application as a disease treatment has been limited in part because of a lack of efficient small interfering RNA (siRNA) delivery systems.

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Surgical frequency analysis of patients clustered according to postoperative pain trajectory: a retrospective study.

Sci Rep

January 2025

Department of Dental Anesthesiology, School of Dentistry and Dental Research Institute, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Oropharyngeal and orthognathic surgeries cause more postoperative pain than simple dental procedures. The lack of detailed pain pattern analysis after dental surgeries makes pain management challenging. We assessed postoperative pain patterns in patients undergoing various dental surgeries, categorized based on changing pain levels, and identified the most frequent surgical procedures within each pain pattern cluster.

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Limited Reconstructive Options of Jaw Osteomyelitis in the Osteopetrosis Patient Complicated by Blood Dyscrasia.

J Craniofac Surg

January 2025

Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.

Osteopetrosis is a rare systemic skeletal disorder characterized by increased bone density and mass resulting from suboptimal or impaired resorption of osteoclastic bone. Compromised bone marrow function and associated disorders of red blood cells contribute to hematopoietic abnormalities, which exacerbate the risk of complex, recurrent infections such as jaw osteomyelitis. This case report describes the treatment of a 68-year-old Korean female with autosomal-dominant osteopetrosis who presented with severe and persistent jaw osteomyelitis complicated by hematopoietic dysregulation.

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Association between Atopic Dermatitis and Dementia: Evidence from Systematic Review, Meta-analysis, and Mendelian Randomization.

Acta Derm Venereol

January 2025

Department of Biomedical Informatics, School of Medicine, Pusan National University, Yangsan, Republic of Korea; Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea.

Recent cohort studies suggest a potential association between atopic dermatitis and dementia, though the evidence remains conflicting. This study aims to elucidate the association between atopic dermatitis and dementia employing systematic review, meta-analysis, and Mendelian randomization (MR). A comprehensive search was performed to select eligible cohort studies using Medline, Embase, Scopus, ScienceDirect, and the Web of Science database.

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Effect of nanoparticulate CaCO on the biological properties of calcium silicate cement.

Sci Rep

January 2025

Department of Dental Biomaterials Science, Dental Research Institute, School of Dentistry, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.

This study aimed to evaluate the effects of nanoparticulate CaCO (NPCC) on the biological properties of calcium silicate-based cements (CSCs), including their cytotoxicity, in vitro osteogenic activity, and interactions with rat femur tissue. The average size of NPCC was 90.3±26.

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Purpose: This study aimed to evaluate the impact of a metal artifact reduction (MAR) algorithm on cone-beam computed tomography (CBCT) scans of titanium and zirconia implants, both within and outside the field of view (FOV).

Materials And Methods: In this study, a dry human mandible was positioned in a CBCT scanner with only its left quadrant included in the FOV. Each type of implant (titanium and zirconia) was placed once in the right second premolar extraction socket and once in the left second premolar extraction socket of the mandible.

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Article Synopsis
  • Pedicle ossification is a rare complication that can occur after using a fibular free flap (FFF) for mandibular reconstruction, potentially simulating tumor recurrence and leading to diagnostic challenges.
  • A case study of a 38-year-old male with squamous cell carcinoma highlighted how postoperative complications led to the need for FFF reconstruction, and over 4 years, CT scans showed ossification in the flap's vascular pedicle, yet the patient remained asymptomatic.
  • Regular imaging and clinical assessments are key to distinguishing ossification from tumor recurrence, with surgery usually only considered if symptoms arise.
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Article Synopsis
  • The study aimed to assess the long-term outcomes of one-piece narrow-diameter implants (NDIs) and identify factors influencing marginal bone loss (MBL) around them.
  • The analysis involved 25 patients and 40 NDIs over an average of 10.5 years, with a high survival rate of 95.1% for implants and a mean MBL of 0.44 mm, primarily linked to the use of guided bone regeneration (GBR).
  • The findings suggest that NDIs perform well clinically over time, showing acceptable MBL, but further research with larger samples is recommended to confirm these results.
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Retrospective analysis of characteristics of patients presenting to the emergency room following dental treatment.

J Korean Assoc Oral Maxillofac Surg

December 2024

Department of Oral and Maxillofacial Surgery, Dental and Life Science Institute & Dental Research Institute, School of Dentistry, Pusan National University, Yangsan, Korea.

Objectives: This study is a retrospective analysis of patients who visited the emergency room (ER) following dental treatment over a period of 3 years, with the aim to enhance the understanding of emergency situations that may arise after dental procedures and to develop appropriate postoperative management and emergency care methods.

Patients And Methods: A total of 796 emergency patients whose visits were attributed to dental procedures, of 4,241 patients who visited the ER at Pusan National University Yangsan Hospital from January 2021 to January 2024, was included in the study. Patients were categorized based on the reason for visit into bleeding, inflammation, and other categories.

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Current options in jaw and facial reconstructions.

J Korean Assoc Oral Maxillofac Surg

December 2024

Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.

In recent years, many advances have been made in surgical fields of oral and maxillofacial reconstruction, and the variety and complexity of available surgical approaches consider different functionalities of the jaw and the aesthetics of the face. There is no validated or scientifically proven basis for deciding which flap to use for reconstruction, so decisions are often made based on the direct and indirect experiential knowledge of the reconstructive surgeon. Considering the modified ladder, elevator, and pie reconstructive options, their risk and donor morbidity, and their long-term outcomes, the simplest option that will achieve the best long-term outcome in terms of form and function and with the lowest donor morbidity should be chosen for the patient's health and social welfare.

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Objectives: This study compared the clinical accuracy of two different stationary face scanners, employing progressive capture and multi-view simultaneous capture scanning technologies.

Methods: Forty dentate volunteers participated in the study. Soft tissue landmarks were marked with a pen on the participants' faces to measure the distances between them.

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The Associate between Energy-Adjusted Dietary Inflammatory Index and Periodontal Disease: A Cross-Sectional Study.

Int J Prev Med

October 2024

Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Previous studies have shown that the dietary inflammatory index (DII) is associated with different health outcomes. However, few studies have investigated the relationship between DII and oral health. We aimed to assess the association between energy-adjusted dietary inflammatory index (E-DII) and periodontal disease.

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Investigation of validity and inter examiner agreement of quantitative light induced fluorescent images in diagnosing cracked teeth.

Sci Rep

December 2024

Department of Conservative Dentistry, Dental and Life Science Institute, School of Dentistry, Dental Research Institute, Pusan National University, Geumo-ro 20, Mulgeum-eup, Box 50612, Yangsan, Republic of Korea.

The images of the Quantitative Light induced Fluorescent (QLF) device, which provides both natural color images similar to those from intraoral cameras and fluorescent images using 405 nm light in a single shot, were evaluated for the validity and inter examiner reliability in detecting tooth cracks. QLF images of 26 cracked teeth before and after removing crack lines were taken. Two examiners assessed the QLF images before removing the crack line with natural color images, fluorescent images, and combination images showing both images simultaneously, and recorded the crack's location after observing images.

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Background: No consensus has been reached on the effect of topical application of amitriptyline and nortriptyline on irreversible pulpitis pain in teeth with failed pulpal anesthesia after a successful inferior alveolar nerve (IAN) block. This study aimed to assess the effect of topical application of amitriptyline and nortriptyline on irreversible pulpitis pain in teeth with failed pulpal anesthesia after a successful IAN block.

Materials And Methods: This double-blind randomized controlled clinical trial was conducted on 45 patients with irreversible pulpitis.

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Background: This systematic review and meta-analysis aimed to assess the efficacy of autologous platelet concentrate (APCs) in comparison with coronally-advanced flap alone or in combination with connective tissue graft or other biomaterials or bioactive agents for root coverage (RC) of Miller's Class I and II gingival recession defects by measuring the keratinized mucosa width (KMW).

Materials And Methods: This systematic review and meta-analysis was conducted in accordance with the preferred reporting items for systematic reviews and meta-analysis guidelines. An electronic search of the literature was conducted in PubMed, EMBASE, Scopus, Cochrane, Web of Science, Magiran, Scientific Information Database, and Irandoc for randomized clinical trials (RCTs) that used APCs for RC in their intervention group.

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Differential Regulatory Effects of Probiotics on Bone Metabolism by the Status of Bone Health and Delivery Route.

Probiotics Antimicrob Proteins

December 2024

Department of Oral Microbiology and Immunology, and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.

Probiotics are known to have favorable effects on human health. Nevertheless, probiotics are not always beneficial and can cause unintended adverse effects such as bacteremia and/or inflammation in immunocompromised patients. In the present study, we investigated the effects of probiotics on the regulation of bone metabolism under different health conditions and delivery routes.

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Statement Of The Problem: Considering side effects of non-steroidal anti-inflammatory drugs (NSAIDs), herbal medicine including  might help reduce the pain.

Purpose: The present study aimed to compare the effects of premedication with essential oil of  and ibuprofen on post-endodontic pain.

Materials And Method: The present randomized clinical trial study was conducted on 60 patients with symptomatic irreversible pulpitis of mandibular first or second molars.

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Muramyl dipeptide potentiates lipoteichoic acid-induced nitric oxide production via TLR2/NOD2/PAFR signaling pathways.

Front Immunol

December 2024

Department of Oral Microbiology and Immunology, and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.

Lipoteichoic acid (LTA) and peptidoglycan (PGN) are considered as key virulence factors of , which is a representative sepsis-causing Gram-positive pathogen. However, cooperative effect of LTA and PGN on nitric oxide (NO) production is still unclear despite the pivotal roles of NO in initiation and progression of sepsis. We here evaluated the cooperative effects of LTA (SaLTA) and muramyl dipeptide (MDP), the minimal structure of PGN, on NO production in both a mouse macrophage-like cell line, RAW 264.

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Aim: To estimate the causal effects of smoking and cessation on tooth loss using instrumental variable (IV) analysis.

Material And Methods: Data from the Behavioural Risk Factor Surveillance System (BRFSS), conducted from 1995 to 2006, 2008, 2010, and 2012 in 50 U.S.

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