Prosthetic considerations and strategies for single tooth implants in the aesthetic zone: a review.

Abutment contours, position, tissue thickness, and volume are all key parameters for the successful restoration of implants in the aesthetic zone. This is particularly true for patients with high smile lines and high aesthetic expectations. This narrative review will provide a synopsis of the known science of implant abutments and peri-implant tissues in this area and cover specialised techniques, materials, and protocols to improve outcomes with increased predictability.

Comparative analysis of deep learning algorithms for dental caries detection and prediction from radiographic images: a comprehensive umbrella review.

Background: In recent years, artificial intelligence (AI) and deep learning (DL) have made a considerable impact in dentistry, specifically in advancing image processing algorithms for detecting caries from radiographical images. Despite this progress, there is still a lack of data on the effectiveness of these algorithms in accurately identifying caries. This study provides an overview aimed at evaluating and comparing reviews that focus on the detection of using DL algorithms from 2D radiographs.

Knockdown Enhances Oral Cancer Cell Chemosensitivity to Cisplatin via Decreased Expression.

Emerging evidence suggests that aberrant expression levels of Sigma1 (, also known as sigma-1 receptor) have been implicated in the progression of various diseases, including cancer. However, its significance in oral cancer (OC) has not been thoroughly explored. To advance in this field, the present study aimed to investigate the impact of knockdown in oral cancer cells.

Zoledronate interrupts pre-osteoclast-induced angiogenesis via SDF-1/CXCR4 pathway.

Introduction: In this study, we tested the hypothesis that pre-osteoclast signaling is key in triggering post-traumatic angiogenesis in alveolar bone via the SDF-1/CXCR4 pathway. Interruption of osteoclast differentiation through zoledronate (Zol) disrupts the crosstalk between pre-osteoclasts and endothelial cells, hindering the initial angiogenic reaction following dental trauma. This disruption could therefore play a role in the pathogenesis of medication-related osteonecrosis of the jaw (MRONJ).

Prescription of potentially inappropriate medications in older adults; data from a dental institution.

Objectives: The objectives of this study were to determine the types and frequency of potentially inappropriate medications (PIMs) prescribed to geriatric patients while considering the patients' age groups and their American Society of Anesthesiologists (ASA) physical status.

Study Design: We performed a 5-year retrospective chart review of patients aged 65 years and above who were seen in a dental institution. Patients' medical history, PIM prescriptions, and prescribers' specialty and professional status were analyzed.

Efficacy of root filling removal from aged, minimally instrumented mandibular molars using a retreatment system combination.

Objective: This study evaluated the efficacy of the ProTaper Universal Retreatment system (PTUR) and XP-endo Finisher R instrument (XPFR) in removing 64-month-old root filling material from minimally-instrumented mandibular molar canals.

Methods: Forty-eight root canals with Vertucci type II or IV configurations from 30 mandibular molars were instrumented to size 20/0.04 taper using Vortex Blue NiTi rotary instruments and irrigated with the GentleWave system.

Advanced Adhesive Approach to Support a Minimally Invasive Full Mouth Rehabilitation.

Objective: Patients who exhibit severe loss of tooth structure are challenging to rehabilitate. Conventional treatment of these patients may require adjunctive procedures of surgical crown lengthening, elective endodontic therapy and placement of posts and cores to retain full coverage crowns as part of a full mouth rehabilitation. Minimally invasive approaches to treatment of these patients provides opportunity to conserve tooth structure and to reduce adjunctive procedures by using an advanced adhesive approach to retain all ceramic partial coverage restorations as part of a full mouth rehabilitation.

Boosting Acetylcholine Signaling by Cannabidiol in a Murine Model of Alzheimer's Disease.

Alzheimer's disease (AD) is a challenging medical issue that requires efficacious treatment options to improve long-term quality of life. Cannabidiol (CBD) is a cannabis-derived phytocannabinoid with potential health benefits, including reports from our laboratory and others showing a therapeutic role in the pre-clinical treatment of AD; however, the mechanisms whereby CBD affects AD progression remain undefined. Innate lymphoid cells (ILCs) are recently discovered immune cells that initiate and orchestrate inflammatory responses.

Periosteum-bone inspired hierarchical scaffold with endogenous piezoelectricity for neuro-vascularized bone regeneration.

The development of scaffolds for repairing critical-sized bone defects heavily relies on establishing a neuro-vascularized network for proper penetration of nerves and blood vessels. Despite significant advancements in using artificial bone-like scaffolds infused with various agents, challenges remain. Natural bone tissue consists of a porous bone matrix surrounded by a neuro-vascularized periosteum, with unique piezoelectric properties essential for bone growth.

Comparing Medium to Long-Term Esthetic, Clinical, and Patient-Reported Outcomes Between Freehand and Computer-Assisted Dental Implant Placement: A Cross-Sectional Study.

Objective: The aim of the study was to compare medium to long-term clinical and patient-reported outcomes between implants placed with computer-assisted implant surgery (CAIS) and freehand protocols.

Materials And Methods: Thirty dental implants in the anterior maxillary region with an average of 4 years after loading were assessed by means of Pink Esthetic Scores (PESs), marginal bone level (MBL), and clinical and patient-reported outcomes.

Results: CAIS significantly outperformed freehand placement with regard to PES scores (p = 0.

Restoration of Non-carious Cervical Lesions: A Brief Review for Clinicians.

Non-carious cervical lesions (NCCLs) become common in individuals over the age of 40 and are progressive. Those that are wedge-shaped in cross-section likely develop hazardous stress concentrations along their sharp axial extent, which can be distributed to lower, safer levels over a larger area via adhesive restoration. Restoration is indicated once a lesion progresses to a minimum restorable axial depth of at least 1.

Ex-vivo evaluation of clinically-set hydraulic sealers used with different canal dryness protocols and obturation techniques: a randomized clinical trial.

Objectives: This 2-part randomized parallel triple-blind clinical trial adopts a unique model assessing clinically-set hydraulic calcium silicate-based sealers (HCSBS) after different root canal dryness protocols and obturation techniques.

Methods: For the first phase of the study, 24 teeth scheduled for orthodontic extractions were allocated into four groups according to the canal dryness protocol and the obturation technique. G1 (CLC-AHP): cold lateral compaction (CLC) with AH Plus sealer, G2 (CLC-ES-SD): CLC with Endosequence (ES) after standard canal(s) dryness (SD); G3 (SC-ES-SD): matching single-cone (SC) with ES after SD; G4 (SC-ES-PD): as G3 but after partial canal(s) dryness (PD).

Impact of Battery Levels of a Cordless LED Curing Unit on Resin Cement under Varied Lithium Disilicate Thicknesses and Translucencies.

Objectives: This study aimed to evaluate the impact of battery levels on the emission of a multi-peak cordless LED light-curing unit (LCU) and the effect on the degree of conversion (DC) and Knoop hardness (KH) of a light-cure resin luting agent activated through varying lithium disilicate (LiS2) ceramic thicknesses and translucencies.

Methods: High and low translucency LiS2 discs (IPS e.max Press HT and LT, respectively; shade A1) with thickness of 0.

Effect of Electrical Stimulation of Lingual Nerve on Xerostomia: A Randomized Controlled Trial.

Introduction: Xerostomia is a subjective sensation of dry mouth affecting millions of people worldwide. Current management has limitations, often causing side effects. This study aims to investigate whether electrical stimulation of the lingual nerve could offer effective relief for xerostomia sufferers.

Effectiveness of pulpotomy in managing carious exposure in mature permanent teeth: A systematic review and meta-analysis.

Objectives: This quantitative systematic review evaluated whether pulpotomy performed with hydraulic calcium silicate cements may be used as an alternative to root canal treatment (RCT) in mature permanent teeth with carious pulp exposure.

Data Sources: A comprehensive search was conducted in PubMed, Web of Science, Scopus, and the Cochrane Library. No language restrictions were applied.

A novel model of autologous tooth transplantation for the study of nerve recruitment.

Background: Limited treatment options exist for damaged nerves and despite impressive advances in tissue engineering, scientists and clinicians have yet to fully replicate nerve development and recruitment. Innervation is a critical feature for normal organ function. While most organs are innervated prior to birth, a rare example of postnatal nerve recruitment occurs in the natural development of secondary teeth during adolescence.