Bayesian network for predicting mandibular third molar extraction difficulty.

Background: This study aimed to establish a model for predicting the difficulty of mandibular third molar extraction based on a Bayesian network to meet following requirements: (1) analyse the interaction of the primary risk factors; (2) output quantitative difficulty-evaluation results based on the patient's personal situation; and (3) identify key surgical points and propose surgical protocols to decrease complications.

Methods: Relevant articles were searched to identify risk factors. Clinical knowledge and experience were used to analyse the risk factors to establish the Bayesian network.

A multi-centre UK-based survey on angioedema secondary to acquired C1 inhibitor deficiency.

Background: Acquired angioedema due to C1-inhibitor deficiency (AAE-C1-INH) is very rare compared to its prototype, hereditary angioedema. An updated characterisation of the AAE-C1-INH cohort in UK is required to inform management.

Objectives: To describe the disease burden of AAE-C1-INH, long-term prophylaxis (LTP) and the clinical, immunochemical and treatment profiles of AAE-associated diseases in UK.

Late onset cerebellar ataxia syndrome after non-paraneoplastic Lambert-Eaton myasthenic syndrome: a case study.

This is an unusual case of voltage gated calcium channel (VGCC) antibodies leading to two distinct and chronologically separated neurologic syndromes without the presence of an underlying neoplasm. Lambert Eaton Myasthenic Syndrome (LEMS) presented five years prior to cerebellar ataxia. Both LEMS and cerebellar ataxia were responsive to treatment, but not the same therapy.

The Association Between Intensive Care Unit Nurses' Perception of Nursing Professional Autonomy and Nursing Professionalism: A Descriptive Correlational Design.

Introduction: The evolving landscape of healthcare in Jordan presents unique challenges and opportunities for nursing professionals. With a focus on critical care nurses, understanding the dynamics of professional autonomy and professionalism within this context is crucial for advancing nursing practice and improving patient care.

Objectives: This study aimed to investigate the relationships between perceived nursing professional autonomy and professionalism among critical care nurses in Jordan.

Curriculum Hours and Approaches to Instruction in Veterinary Ophthalmology: A Global Survey of Veterinary Schools.

Reports regarding curricula in ophthalmology across veterinary schools are not currently available. The objective of this study was therefore to investigate the number of contact hours and approaches to teaching ophthalmology in the curriculum of English-speaking veterinary schools worldwide. An online survey was distributed to 51 veterinary colleges in North America, the United Kingdom, Australia, New Zealand, and the Caribbean.

Putative signaling pathways for contraction and its recovery from DEHP arrest in Hymeniacidon heliophila.

With sessile habits, sponges (phylum Porifera) are susceptible to marine pollution impacts and recently microplastics were identified as one source of contamination. Microplastics have a physical impact on filtration rates and plastics additives such as di(2-ethylhexyl)phthalate (DEHP), a ubiquitous marine contaminant, were already identified in their tissues indicating bioaccumulation. However, few studies assessed the impacts of such compounds in its physiology.

Fault Diagnosis Method for Converter Stations Based on Fault Area Identification and Evidence Information Fusion.

DC converter stations have a high voltage level, a long transmission distance, and complex internal equipment, and contain power electronic devices, which seriously endanger the stable operation of the system itself and the active distribution network at the receiving end when faults occur. Accurate fault analysis and diagnosis are critical to the safe and stable operation of power systems. Traditional fault diagnosis methods often rely on a single source of information, leading to issues such as insufficient information utilization and incomplete diagnostic scope when applied to DC transmission systems.

Salivary Metabolic Pathway Alterations in Brazilian E-Cigarette Users.

In recent years, the use of electronic cigarettes (e-cigs) has increased. However, their long-term effects on oral health and saliva remain poorly understood. Therefore, this study aimed to evaluate the saliva of e-cig users and investigate possible biomarkers.

A conflict-free multi-modal fusion network with spatial reinforcement transformers for brain tumor segmentation.

Brain gliomas are a leading cause of cancer mortality worldwide. Existing glioma segmentation approaches using multi-modal inputs often rely on a simplistic approach of stacking images from all modalities, disregarding modality-specific features that could optimize diagnostic outcomes. This paper introduces STE-Net, a spatial reinforcement hybrid Transformer-based tri-branch multi-modal evidential fusion network designed for conflict-free brain tumor segmentation.

Essentials of genomics in nursing undergraduate education: A discussion paper.

Aim: To map the 2021 American Association of Colleges of Nursing Essentials to the American Nurses Association Essentials of Genomic Nursing for all nurses and provide resources for nursing faculty to support the seamless integration of genomics into existing undergraduate curricula.

Background: Since the completion of the Human Genome Project in 2003, rapid advancements in genomic science leading to practical applications of genomics have revolutionized all areas of healthcare. Nursing is built on foundational life sciences, including genomics.

The present and future of the Cancer Dependency Map.

Despite tremendous progress in the past decade, the complex and heterogeneous nature of cancer complicates efforts to identify new therapies and therapeutic combinations that achieve durable responses in most patients. Further advances in cancer therapy will rely, in part, on the development of targeted therapeutics matched with the genetic and molecular characteristics of cancer. The Cancer Dependency Map (DepMap) is a large-scale data repository and research platform, aiming to systematically reveal the landscape of cancer vulnerabilities in thousands of genetically and molecularly annotated cancer models.

A Trustworthy Curriculum Learning Guided Multi-Target Domain Adaptation Network for Autism Spectrum Disorder Classification.

Domain adaptation has demonstrated success in classification of multi-center autism spectrum disorder (ASD). However, current domain adaptation methods primarily focus on classifying data in a single target domain with the assistance of one or multiple source domains, lacking the capability to address the clinical scenario of identifying ASD in multiple target domains. In response to this limitation, we propose a Trustworthy Curriculum Learning Guided Multi-Target Domain Adaptation (TCL-MTDA) network for identifying ASD in multiple target domains.

Longitudinal changes in DNA methylation associated with clozapine use in treatment-resistant schizophrenia from two international cohorts.

The second-generation antipsychotic clozapine is used as a medication for treatment-resistant schizophrenia. It has previously been associated with epigenetic changes in pre-clinical rodent models and cross-sectional studies of treatment-resistant schizophrenia. Cross-sectional studies are susceptible to confounding, however, and cannot disentangle the effects of diagnosis and medication.

Random walk in random permutation set theory.

Random walk is an explainable approach for modeling natural processes at the molecular level. The random permutation set theory (RPST) serves as a framework for uncertainty reasoning, extending the applicability of Dempster-Shafer theory. Recent explorations indicate a promising link between RPST and random walk.

A case of cardiorespiratory collapse following bilateral sub-Tenon's blocks from brainstem anaesthesia.

Sub-Tenon's block has a superior safety profile and life-threatening complications such as cardiovascular collapse and brainstem anaesthesia are extremely rare. We report a case of cardiorespiratory collapse following bilateral sub-Tenon's blocks at the conclusion of a laser photocoagulation procedure under general anaesthesia. The cause was most likely brainstem anaesthesia.

Buprenorphine for the Treatment of Military-related PTSD With Treatment-resistant Depression and Unexpected Benefit for Chronic Pain: Case Report.

The prevalence of treatment-resistant depression within global and military populations highlights the need for novel treatment approaches beyond monoamine neurotransmitter modulators. Buprenorphine (BUP), a semi-synthetic partial opioid agonist, is approved for the treatment of opioid use disorder and has shown promise in treating both depression and chronic pain. This case report discusses the use of transdermal BUP in treating a 36 year-old man with treatment-resistant depression with prominent anhedonia, military-related posttraumatic stress disorder, and chronic pain because of barosinusitis.

TMODINET: A trustworthy multi-omics dynamic learning integration network for cancer diagnostic.

Multiple types of omics data contain a wealth of biomedical information which reflect different aspects of clinical samples. Multi-omics integrated analysis is more likely to lead to more accurate clinical decisions. Existing cancer diagnostic methods based on multi-omics data integration mainly focus on the classification accuracy of the model, while neglecting the interpretability of the internal mechanism and the reliability of the results, which are crucial in specific domains such as precision medicine and the life sciences.

Safety risk assessment of reservoir dam structure: an empirical study in China.

Reservoir dam structure is critical to protect public life and property and has always been attention worldwide. However, a systematic approach to assessing the safety risks of reservoir dam structure (RDS) is still required. This study presents a holistic framework for evaluating the safety risk of RDS and develops an evaluation index system.

Optimal Treatment Strategies for cT2 Staged Adenocarcinoma of the Esophagus and the Gastroesophageal Junction: A Multinational, High-volume Center Retrospective Cohort Analysis.

Objective: To evaluate outcomes after primary surgery (PS) or neoadjuvant treatment followed by surgery (NAT/S) in cT2 staged adenocarcinomas of the esophagus (EAC) and gastroesophageal junction (GEJ), a multinational high-volume center study was undertaken.

Background: The optimal treatment approach with either NAT/S or PS for clinically staged cT2cN any or cT2N0 EAC and GEJ remains unknown due to the lack of randomized controlled trials.

Methods: A retrospective analysis of prospectively maintained databases from 10 centers was performed.