MicroRΝΑ analysis in patients with myelodysplastic neoplasms. Possible implications in risk stratification.

MiRNAs have been identified as participants in leukemogenesis by controlling several cellular functions, such as differentiation, proliferation, and apoptosis. Their role in myelodysplastic neoplasms (MDS) pathogenesis is researched due to implementations in early identification, classification, and therapeutical options. IPSS-R, being the most widely used MDS classification, underestimates early biological events that can alter the disease's prognosis.

Occupational Exposure to Pesticides, Personal Protection, and Willingness to Reduce Chemical Sprayings Among Iranian Greenhouse Farmers.

Objectives: The level of greenhouse farmers' personal protection in pesticide use and the possibility of environmental protection through farmers' willingness to reduce chemical sprayings were assessed in Khuzestan Province, Iran.

Methods: A survey of 80 active greenhouse vegetable growers was carried out in 2021 with face-to-face interviews. Willingness to reduce chemical sprayings was examined with the theory of planned behavior (TPB) model.

Alterations of energy expenditure after anterior cruciate ligament tear and reconstruction. A systematic review.

Background: The ever-increasing sport level makes every single detail of the athlete's cardiorespiratory profile count, and therefore, it is deemed crucial to clarify how the anterior cruciate ligament (ACL) reconstruction (ACLR) affects the energy economy of an athlete compared to the ACL-deficient and healthy subjects. The purpose of this review was to systematically analyze the studies investigating the correlation between the energy-oxygen cost in patients following ACLR in unreconstructed and intact ACLs.

Methods: We conducted this systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines.

Parricide and homicide NGRI offenders: How do they differ?

The aim of the present study was to provide a forensic psychiatric characterization of perpetrators of parricide who were found not guilty by reason of insanity (NGRI). We conducted a study involving 52 NGRI patients who had committed homicide or attempted homicide within the Department of Forensic Psychiatry in Thessaloniki, Greece, between January 2015 and 2020. Subjects were categorized into two groups: parricide ( = 21) and a control group ( = 31).

Leaching and geochemical modeling of asbestos-cement waste and mine asbestos.

Asbestos-Containing Materials (ACMs) were widely used in the construction sector but, due to their harmful health effects, many countries have banned their use. ACMs are classified as hazardous and, in contact with water, produce potentially harmful leachates. The objective of this work was to determine the leaching behavior of 20 elements from two asbestos-cement materials and mine asbestos samples across the entire pH range and varying liquid-to-solid ratios (column tests).

Diet patterns, gut microbiota and metabolic disorders: Perspectives and challenges.

The worldwide surge in obesity and associated metabolic disorders is emerging as a significant public health issue for societies and healthcare systems. Available evidence has shown that alterations in the gut microbiota could be implicated in the pathogenesis of obesity and associated disorders. A healthy gut microbiome is characterized by richness and high microbial diversity.

Neutrophil-fibroblast crosstalk drives immunofibrosis in Crohn's disease through IFNα pathway.

Introduction: Crohn's disease (CD) is characterized by chronic inflammation and intestinal fibrosis leading to lifelong complications. However, the disease pathogenesis remains elusive, and the therapeutic options are limited. Here, we investigated the interaction between neutrophils and intestinal fibroblasts in the development of CD immunofibrosis, a disease mechanism predisposing to inflammatory and fibrotic complications.

Innovative Fiber-Reinforced Polymer Rope-Based Closed-Form Retrofitting Methods Applied in Reinforced Concrete T-Shaped Beams under Torsion.

The fiber-reinforced polymer (FRP) strengthening of reinforced concrete (RC) elements with torsional deficiencies has not yet been extensively studied. Existing studies have primarily focused on rectangular RC beams. The few studies on L or T-shaped beams have used open-form retrofitting methods.

Sperm DNA Fragmentation: Unraveling Its Imperative Impact on Male Infertility Based on Recent Evidence.

Male factors may be present in up to 50-70% of infertile couples and the prevalence of male infertility accounts for 20-30% of infertility cases. Understanding the mechanisms and causes behind male infertility remains a challenge, but new diagnostic tools such as DNA fragmentation might aid in cases where the routine semen analysis is insufficient. DNA fragmentation, which refers to damages or breaks of the genetic material of the spermatozoa, is considered one of the main causes of male infertility due to impaired functional capability of sperm.

Unraveling Childhood Obesity: A Grounded Theory Approach to Psychological, Social, Parental, and Biological Factors.

Childhood obesity is a major medical and public health issue of global interest, which is influenced by a diverse array of factors and carries significant medical and psychosocial implications. Despite the extensive studies that have been conducted to explore the specific issue, the impact of several factors that influence, generate, worsen, and make chronic the phenomenon needs further exploration. This study aimed to construct a grounded theory that includes and connects the psychological, social, parental, and biological factors affecting childhood obesity.

The Impact of Heat Exposure on the Health and Performance of Soccer Players: A Narrative Review and Bibliometric Analysis.

The impact of heat exposure on the health and performance of soccer players is a widely discussed topic. The purpose of this study is to provide a comprehensive overview of the international literature that has addressed this issue. To achieve this objective, we initially conducted a bibliometric analysis and a literature review of the main topics that emerged through bibliometric techniques.

A Novel Phage against Bearing a Unique Gene of Intergeneric Origin.

Antibiotics resistance is expanding amongst pathogenic bacteria. Phage therapy is a revived concept for targeting bacteria with multiple antibiotics resistances. In the present study, we isolated and characterized a novel phage from hospital treatment plant input, using () as host bacterium.

The Impact of Human Papillomavirus Infections on Recurrent Pregnancy Loss: A Review of the Literature.

Human papillomavirus (HPV) infections are significantly associated with multiple adverse reproductive outcomes such as miscarriages. Pregnant women are more susceptible to an HPV infection and its prevalence increases as pregnancy progresses. In this present review, we summarize the existing evidence indicating the potential impact of an HPV infection on the occurrence of recurrent pregnancy loss (RPL).

Evolving patterns of intracranial hemorrhage in advanced therapies in patients with acute pulmonary embolism.

Background: Dissecting trends and contributing risk factors for intracranial hemorrhage (ICH) in patients treated for acute pulmonary embolism (PE) may allow for a better patient selection for existing and emerging treatment options.

Methods: The German nationwide inpatient sample was screened for patients admitted due to PE 2005-2020. Hospitalizations were stratified for the occurrence of ICH; risk factors for ICH and temporal trends were investigated.

Low-Grade Activation of the Extrinsic Coagulation Pathway in Patients with Ulcerative Colitis.

Background: Ulcerative colitis (UC) increases the risk for venous thromboembolism. Tissue factor (TF) initiates the extrinsic coagulation pathway (ECP).

Aims: To investigate the correlation of UC severity with latent ECP activation and TF expression in primary colonic stromal cells (PCSC).