9,271 results match your criteria: "Delusional Disorder"
Towards the DSM-6: The intersection of OCD and psychosis. Expert perspectives on insight in the diagnosis of OCD.
Psychiatry Res
November 2024
Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
In 1994, the DSM-IV added the specifier "with poor insight" to the diagnostic criteria of obsessive-compulsive disorder (OCD). The DSM-5 went one step further and now allows clinicians to diagnose OCD "with absent insight/delusional beliefs," thereby blurring the long-standing distinction between OCD and psychosis. The present study surveyed OCD experts as to their opinions on the insight specifier and the future classification of OCD.
View Article and Find Full Text PDFPotential research priorities for understanding and treating severe paranoia (persecutory delusions): a priority-setting partnership between patients, carers, mental health staff, and researchers.
BMJ Ment Health
December 2024
Department of Experimental Psychology, University of Oxford, Oxford, UK.
Article Synopsis
- The text discusses severe paranoia, a type of persecutory delusion commonly seen in schizophrenia, where individuals mistakenly believe they are being harmed by others.
- The study aimed to identify and prioritize important research questions regarding severe paranoia through surveys involving patients, families, mental health staff, and researchers.
- Findings revealed 15 key research questions of consensus among stakeholders, focusing on understanding paranoia, supporting affected individuals and families, and improving treatment options.
[An individual approach to the diagnosis and treatment of an acute psychotic condition in a patient with a multiple sclerosis].
Zh Nevrol Psikhiatr Im S S Korsakova
November 2024
South Ural State Medical University, Chelyabinsk, Russia.
Article Synopsis
- Acute psychotic states occur in 2-3% of multiple sclerosis (MS) patients, and differentiating between organic and endogenous causes is crucial for diagnosis.
- Factors such as disease exacerbation, prior mental issues, and reactions to corticosteroids or antipsychotics play a role in this differentiation.
- The article discusses a specific case that highlights diagnostic challenges and the complexities of selecting effective antipsychotic treatments years after an MS diagnosis.
Article Synopsis
- - Schizophrenia is characterized by symptoms like hallucinations and delusions, with significant challenges in recognizing facial emotions, especially negative ones, which are crucial for effective social interactions.
- - The study compares facial emotion recognition abilities among paranoid schizophrenia patients, non-paranoid patients, their siblings, and healthy controls, involving 60 participants from each group.
- - Results indicate that paranoid schizophrenia patients performed worse in recognizing negative emotions compared to non-paranoid patients and their siblings, suggesting potential genetic links to these social cognition deficits.
Refractory status epilepticus seen in the early phase of sporadic Creutzfeldt-Jakob disease.
BMJ Case Rep
November 2024
Neurology, Northampton General Hospital NHS Trust, Northampton, Northamptonshire, UK.
Article Synopsis
- A 60-something male patient experienced worsening symptoms like confusion, paranoia, cognitive decline, and myoclonus, all while having a history of paranoid schizophrenia.
- Extensive medical tests, including blood work and brain scans (MRI), did not provide clear answers but showed abnormal brain activity and damage in specific areas.
- An electroencephalogram (EEG) revealed abnormal sharp wave discharges, indicating the patient was likely in a state of status epilepticus, a severe epileptic condition.
Brexpiprazole for a Patient with Ekbom Syndrome with Intolerable Side Effect of Aripiprazole.
Psychiatry Clin Psychopharmacol
September 2024
Department of Psychiatry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Article Synopsis
- Ekbom's syndrome, or delusional parasitosis, is a rare psychiatric disorder characterized by a strong belief in having an infestation without hallucinations or major thought issues.
- It has two forms: primary, which features delusions and unusual sensations, and secondary, caused by an underlying health issue.
- A case study shows that atypical antipsychotics like aripiprazole and brexpiprazole can effectively treat primary Ekbom's syndrome, with brexpiprazole potentially causing fewer side effects like tremors.
Substance use and lifestyle risk factors for somatic disorders among psychiatric patients in Greenland.
Int J Circumpolar Health
December 2024
Department of Medicine, Center for Primary Health Care in Nuuk, Nuuk, Greenland.
Article Synopsis
- - Patients with psychotic disorders, particularly in Nuuk, show higher rates of mortality and health issues mainly due to other physical diseases, as highlighted in a recent study.
- - The research analyzed 104 patients (68 males, 36 females) with a mean age of 40, revealing significant risk factors such as high smoking rates (over 80%) and harmful cannabis use (68%), as well as prevalent issues like dyslipidemia and obesity.
- - The findings suggest a concerning trend of comorbid somatic conditions that may worsen with age, calling for improved healthcare strategies focused on monitoring and preventing these risk factors among psychotic disorder patients.
Schizotypy 17 years on: Prediction of schizotypic individual differences in midlife.
J Psychopathol Clin Sci
October 2024
Department of Psychology, State University of New York at Binghamton.
Article Synopsis
- The study investigates the long-term effects of schizotypy assessed during late adolescence on future schizotypic features in midlife.
- Findings reveal that early schizotypy predicts increased schizotypal and paranoid personality traits as well as schizophrenia proneness in participants around age 35.
- This research supports the idea that schizotypy serves as an underlying risk factor for developing schizotypic psychopathology, emphasizing the value of longitudinal studies in understanding schizophrenia-related issues.
Late-onset delusional disorder as psychiatric-onset dementia with Lewy bodies: a longitudinal follow-up study.
Asian J Psychiatr
December 2024
Department of Psychiatry, Nagoya University Graduate School of Medicine, Japan. Electronic address:
Prevalence of schizophrenia spectrum disorders in the Lazio region, Italy: use of an algorithm based on health administrative databases.
BMC Psychiatry
October 2024
Department of Epidemiology of the Regional Health Service - Lazio Region, ASL Roma 1, Via Cristoforo Colombo 112, Rome, 00147, Italy.
Article Synopsis
- The study aimed to estimate the prevalence and distribution of schizophrenia spectrum disorders (SSD) in the Lazio region using healthcare databases from 2006 to 2019.
- Researchers found a total of 18,371 cases, resulting in an overall prevalence of 5.03 per 1000 people, with notable variations based on age and geographical areas within the region.
- The findings indicated that SSD is more prevalent among older adults and men, with conditions like schizophrenia and schizoaffective disorder being the most common, highlighting the importance of using administrative data for epidemiological research.
From Psychiatric Care to Dermatologic Dilemmas: A Case Report of Risperidone-Induced Bullous Pemphigoid.
Cureus
September 2024
Psychiatry, All India Institute of Medical Sciences, Gorakhpur, Gorakhpur, IND.
Article Synopsis
- - The patient is a 64-year-old male with a long history of delusional disorder, first showing symptoms at age 34, which were managed successfully for years until a relapse occurred.
- - Initial treatment with amisulpride failed, and risperidone caused severe skin reactions leading to a diagnosis of bullous pemphigoid, prompting a switch to other medications.
- - The introduction of aripiprazole and melatonin resulted in improved management of both delusional symptoms and the skin condition, illustrating the importance of monitoring for drug-induced side effects in elderly patients on antipsychotics.
Article Synopsis
- Delusional parasitosis is a psychotic disorder where individuals believe they are infested with parasites, while shared paranoid disorder (folie à deux) occurs when two closely related people share similar delusions.
- A case study involving a married couple revealed that the husband experienced sensations and beliefs about parasites, leading to the wife also developing similar symptoms, indicating a shared delusion.
- Treatment included medications like sertraline and risperidone, but due to side effects and financial constraints, the husband's condition required adjustments, and separating the couple's sleeping arrangements significantly alleviated the wife's symptoms.
Article Synopsis
- Millions rely on the Internet for health-related information, but many struggle with low health literacy, especially those with severe mental illnesses, which can lead to worse outcomes and limited healthcare access.
- * The study analyzed the readability of top five websites for eight common psychotic disorders, assessing them with the Flesch-Kincaid readability formulas.
- * Results showed the overall readability was too advanced for the average U.S. adult reading level, with websites discussing major depressive disorder being the easiest and those on delusional disorder being the hardest to understand.
Interictal psychosis of epilepsy: What is the role of the neurologist?
Epilepsy Behav Rep
September 2024
Epilepsy Division, Department of Neurology, University of Miami, Miller School of Medicine, Miami, FL, USA.
Article Synopsis
- Psychotic disorders are more common in people with epilepsy, often needing quick treatment with antipsychotic medication, especially when access to psychiatrists is limited.
- The manuscript reviews a case of a 45-year-old man with treatment-resistant epilepsy who developed a new psychotic episode, successfully treated with aripiprazole.
- Early intervention for interictal psychotic episodes is crucial for better outcomes, and these cases typically respond well to lower doses of antipsychotic drugs compared to primary psychotic disorders.
Multiple complex developmental disorder (MCDD): Did we throw the baby out with the bathwater too fast? A systematic review.
Clin Child Psychol Psychiatry
January 2025
Department of Mental Health and Pathological Addiction, Child and Adolescent Neuropsychiatry Service,Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Article Synopsis
- Multiple Complex Developmental Disorder (MCDD) is a condition that affects various areas of development and could be seen as lying between autism and childhood-onset schizophrenia, but interest in it has decreased over time.
- This study systematically reviewed literature on MCDD to evaluate its current significance, finding only 16 relevant studies that varied widely in methodology and focus.
- The analysis revealed that children with MCDD tended to experience more paranoia and psychotic symptoms compared to those with autism, highlighting a potential diagnostic gap that warrants further investigation.
Genetic overlap between schizophrenia spectrum disorders and Alzheimer's disease: Current evidence and future directions - An integrative review.
Neurosci Biobehav Rev
December 2024
Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan.
Article Synopsis
- * Patients with schizophrenia or delusional disorder, especially older women, are at a higher risk for developing Alzheimer's, while a significant percentage of Alzheimer's patients experience psychotic symptoms that can worsen their condition.
- * The review highlights weak genetic correlations between schizophrenia and Alzheimer's, pointing out inconsistencies in polygenic risk scores, and underscores the need for further research into their genetic links and impacts on treatment and prevention strategies.
Distinguishing Reality: A Case of Delusional Misidentification Syndrome in a 39-Year-Old Male.
Cureus
August 2024
Medical Education, Lakeland Regional Health, Lakeland, USA.
Article Synopsis
- * It may arise from disruptions in the brain's frontal, limbic, and temporal areas that affect face recognition and emotional responses, with risk factors including neurological disorders and schizophrenia.
- * A case of a 39-year-old male with a traumatic brain injury and a family history of schizophrenia is presented, who experienced paranoia and delusions about his father being an imposter; he was treated with olanzapine and stabilized before discharge.
Delusional Parasitosis in a Patient With a History of COVID-19 and Substance Use Disorder.
Perm J
December 2024
Psychiatry, Olive View-University of California Los Angeles Medical Center, Los Angeles, CA, USA.
Article Synopsis
- Delusional parasitosis is a psychotic disorder where individuals mistakenly believe their skin is infested with parasites.
- A case report highlights a 28-year-old male who developed new-onset delusional parasitosis after contracting COVID-19, complicating his preexisting psychosis.
- The patient was treated with olanzapine, showing some reduction in delusions, and the report emphasizes the need for closer monitoring of COVID-positive patients experiencing psychosis.
Involvement of CXCL10 rs4256246, CXCR4 rs2228014, CCR2 rs1799864 and CXCL16 rs2277680 in the Predisposition to Schizophrenia.
J Mol Neurosci
September 2024
Laboratory of Genetics, Biodiversity and Bioresource Valorization (LR11ES41), Higher Institute of Biotechnology of Monastir, University of Monastir, Monastir, Tunisia.
Article Synopsis
- This study investigates the role of specific chemokine gene polymorphisms (CXCL10, CXCR4, CCR2, CXCL16) in the development of schizophrenia (SCZ) among a Tunisian cohort.
- Findings reveal that the minor allele A of CXCL10 increases the risk of SCZ, particularly in paranoid patients with late-onset, while the mutated allele T of CXCR4 offers significant protection against the disorder, especially in males.
- Additional analyses link CCR2 and CXCL16 polymorphisms to clinical symptoms in disorganized patients, highlighting the need for further research to confirm these associations and understand their implications.
Dangerous Intersection of Alcoholism and Othello Syndrome: A Comprehensive Review of Delusional Jealousy and Treatment Strategies.
Med Sci Monit
September 2024
II Department of Psychiatry and Psychiatric Rehabilitation, Medical University of Lublin, Lublin, Poland.
Article Synopsis
- - The rise in alcohol addiction is linked to modern stress, accessibility to substances, and its serious consequences, such as brain damage leading to Othello syndrome, a form of delusional disorder characterized by unfounded beliefs of a partner's infidelity.
- - Othello syndrome, often resulting from chronic alcohol use, can lead to aggressive behavior towards partners and oneself, posing risks of violence or self-harm.
- - Treatments include antipsychotic medications, serotonin reuptake inhibitors, and promising research on oxytocin, along with therapy for alcohol addiction and underlying mental health issues to manage this dangerous condition.
Successful Treatment of Risperidone-Induced Hypothermia With Aripiprazole: A Brief Case Report and a Literature Review.
Cureus
August 2024
Department of Psychiatry, MedStar Washington Hospital Center, Washington, DC, USA.
Article Synopsis
- Hypothermia can be a serious condition caused by various factors, including the use of certain medications like antipsychotics, which may lead to decreased body temperature 7-10 days after dosage changes.
- A case study involves a 68-year-old man with multiple health issues, who showed persistent hypothermia even after external warming efforts but improved after switching from risperidone to aripiprazole.
- It's important for healthcare providers to monitor patients on antipsychotics for hypothermia symptoms and check their vital signs regularly for early identification and treatment.
Study of the influence of disease duration on glutatione-dependent ensymes dynamics in patients with paranoid schizophrenia.
Wiad Lek
September 2024
IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE.
Article Synopsis
- - The research aimed to analyze how the functionality of the glutathione system changes over time in individuals with paranoid schizophrenia, focusing on the activities of specific glutathione-dependent enzymes based on how long the patients have had the illness.
- - A total of 300 patients were divided into five groups based on the duration of their illness, with findings showing a significant decrease in the activity of key enzymes like glutathione peroxidase and glutathione reductase, especially pronounced in those with 3-5 years of illness.
- - The study highlights critical periods of glutathione system inhibition, suggesting important implications for future treatments in managing paranoid schizophrenia.
A combined tropical medicine and psychiatry approach to patients with possible delusional infestation.
Trans R Soc Trop Med Hyg
December 2024
Wrexham Maelor Hospital Psychiatric Liaison Team, Wrexham LL13 7TD, UK.
Article Synopsis
- Delusional infestation (DI) is a psychological disorder where individuals have a firm belief that they are infested, requiring an interdisciplinary approach for effective treatment.
- The Liverpool University Hospitals NHS Foundation Trust operates a specialized clinic for DI, coordinating between dermatology and psychiatry to enhance patient care and management.
- From 2018 to 2023, this clinic assessed 208 patients, with over half diagnosed with DI, indicating the need for targeted strategies in similar medical settings.