Anionic polysaccharides mixture control the assembly of nanoscale building blocks of calcium carbonate into hierarchical spherical and rod-shaped mesocrystals.

Biominerals, as complex organic-inorganic nanocomposites synthesized by organisms, exhibit unique properties across various scales. This study investigates the role of soluble organic molecules, specifically acidic polysaccharides such as N-carboxymethyl chitosan (CMC) and chondroitin 6-sulfate (ChS), in regulating the formation of calcium carbonate mesocrystals. Using a precipitation method, the effects of these polymers on the morphology, size, and polymorphism of mesocrystals were evaluated.

PU-H71 (NSC 750424): a molecular masterpiece that targets HSP90 in cancer and beyond.

Heat shock protein 90 (HSP90) is a pivotal molecular chaperone with multifaceted roles in cellular health and disease. Herein, we explore how HSP90 orchestrates cellular stress responses, particularly through its partnership with heat shock factor 1 (HSF-1). PU-H71, a selective inhibitor of HSP90, demonstrates significant potential in cancer therapy by targeting a wide array of oncogenic pathways.

Evaluation of pain intensity and airway changes in non-growing patients treated by MARPE with and without micro-osteoperforation: a randomized clinical trial.

Trial Design: Parallel.

Objectives: To assess the effect of mini-screw assisted rapid palatal expansion (MARPE) with/without micro-osteoperforation (MOP) on the airway and pain intensity in non-growing patients with maxillary transverse deficiency.

Method: Two equal groups of twenty-four individuals aged ≥ 19 years old with maxillary transverse deficit were randomly assigned.

Therapeutic and toxicological assessment of hydroethanolic leaf extracts of in apparently healthy rats.

Unlabelled: The use of medicinal plants in the management or prevention of diseases is one of the oldest human medicinal practices worldwide. and are widely reported for their use in the management of blood disorders, hypertension, and diabetes.

Objective: The study aimed at evaluating the effects of hydroethanolic leaf extracts of and on the biochemical, hematological, and histological parameters of apparently healthy rats.

Burkholderia cepacia Infective Endocarditis of Native Aortic Valve: A Case Report and Review of Literature.

Infective endocarditis (IE) is a serious cardiac infection of the endocardium, native and prosthetic valves, or cardiac device. In this case study, we report a case of an immunocompetent patient with severe aortic valve endocarditis. A 54-year-old female presented to the emergency department with progressive shortness of breath, chest pain, palpitations, and cough for a period of 20 days.

RELATIONSHIP BETWEEN HOUSEHOLD FOOD INSECURITY AND NUTRITIONAL STATUS OF CHILDREN AGED 6-59 MONTHS IN YENAGOA LOCAL GOVERNMENT AREA, BAYELSA STATE, NIGERIA.

Background: Household Food Insecurity (HFI) is closely linked with nutritional status. The Global Report on Food Crises 2019 reported more than 113 million people face food insecurity hence the need to address Food insecurity in line with Sustainable Development Goal 2 which seeks to achieve food security and improve nutrition by 2030.

Objectives: To determine the prevalence of HFI, compare the nutritional status of children aged 6-59 months in food-secure and food-insecure households, and determine the predictors of malnutrition in food-insecure households in Yenagoa LGA, Bayelsa State.

Implant Stability and Marginal Bone Changes Associated with Different Staged Ridge-splitting Techniques Using Piezoelectric Surgery in Atrophic Posterior Mandible:A Comparative Study.

Aim: The ridge-splitting technique is considered one of the common solutions for horizontal ridge augmentation. The study evaluated implant stability and marginal bone loss after two vs three staged ridge-splitting technique.

Materials And Methods: Twelve dental implants were inserted into 10 patients through staged ridge-splitting approach.

Diltiazem mitigates acute liver injury by targeting NFκB-TXNIP/NLRP3 axis in Rats: New insights beyond calcium channel blockade.

Acute liver injury is characterized by the rapid onset of inflammation in the liver, which in turn plays a role in the development of hypertension. Additionally, hypertension increases susceptibility to liver diseases associated with inflammatory states. Recently, the antihypertensive drug diltiazem has demonstrated anti-inflammatory properties and has been shown to inhibit the expression of the thioredoxin-interacting protein (TXNIP), an upstream regulator of the NOD-like receptor pyrin-3 (NLRP3) inflammasome pathway.

Therapeutic potential of hyaluronic acid hydrogel combined with bone marrow stem cells-conditioned medium on arthritic rats' TMJs.

Conditioned media (CM) is derived from mesenchymal stem cells (MSC) culture and contains biologically active components. CM is easy to handle and reduces inflammation while repairing injured joints. Combination therapy of the CM with cross-linked hyaluronic acid (HA) could ameliorate the beneficial effect of HA in treating degenerative changes of articulating surfaces associated with arthritic rats' temporomandibular joints (TMJs).

Evaluation of two different self-disinfection alginate impression material.

Objective: This study was conducted to evaluate the antimicrobial efficacy and mechanical properties of two experimental self-disinfecting alginate preparations utilising two different antimicrobial agents; povidone-iodine and silver nanoparticles.

Methods: Alginate moulds were assigned into three groups. Additives-free control group, povidone-iodine-containing group, and silver nanoparticle-containing group.

Effects of freezing of gait on vertical ground reaction force in Parkinson's disease.

Vertical ground reaction force (vGRF) is a main kinetic gait analysis explaining body weight loading patterns. The study primarily aimed to understand effects of Freezing of gait (FoG) on vGRF in Parkinson's disease (PD). A secondary analysis for a walking dataset including biomechanical analyses for 26 PD participants (13 with FoG) was performed.

Are cervical curvature and axioscapular muscle activity associated with disability in patients with chronic nonspecific neck pain? - a cross sectional exploratory study.

Purpose: To ascertain the relationship between cervical curvature, neck muscle activity and neck disability in patients with chronic nonspecific neck pain (CNNP).

Methods: Ninety participants (mean age = 27.2, female/male ratio = 7/2) with CNNP volunteered.

The application of medical ethics in the developing countries - A neurosurgical perspective.

Introduction: Neurosurgery is one of the rapidly evolving specialities of medical science, where the neurosurgeons have to provide evidence-based interventions in life threatening conditions maintaining the ethical standards.

Research Question: This narrative review sheds light on the current hindrances of the ethical aspects of neurosurgical practice in low and middle-income countries (LMICs) and provide some feasible solutions for future.

Material And Methods: A literature search was conducted using PubMed, Scopus and ISI web of knowledge focused on articles in English with the words "medical ethics" together with the words "neurosurgery", "ethical practice", "low and middle-income countries", "surgical innovation", "randomized clinical trials" and "outcome" alone or in combination.

Unlocking vinpocetine's oncostatic potential in early-stage hepatocellular carcinoma: A new approach to oncogenic modulation by a nootropic drug.

The development of new drugs for the inhibition of hepatocellular carcinoma (HCC) development and progression is a critical and urgent need. The median survival rate for HCC patients remains disappointingly low. Vinpocetine is a safe nootropic agent that is often used to enhance cognitive function.

Nanostructured biloalbuminosomes loaded with berberine and berberrubine for Alleviating heavy Metal-Induced male infertility in rats.

Despite the remarkable biological effects of berberine (BBR), particularly on fertility, its bioavailability is low. This study aims to test the effectiveness of novel nanostructured biloalbuminosomes (BILS) of BBR and its metabolite berberrubine (M1) in treatment of testicular and prostatic lesions. M1 was semi-synthesized from BBR using microwave-assisted reaction.

Heel Raises and Calf Stretches Exercises Versus Medication Only in Ischemic Intermittent Claudication: A Randomized Controlled Trial.

Intermittent claudication is a primary symptom of peripheral artery disease (PAD). a chronic progressive disease caused primarily by atherosclerosis. It is usually characterized by leg pain, aches, cramps, or fatigue when walking, which improves with rest.

Effect of green coffee on miR-133a, miR-155 and inflammatory biomarkers in obese individuals.

Objectives: Metabolic syndrome is a cluster of conditions that increases the risk of atherosclerotic cardiovascular diseases. The current study was a randomized, double blind, placebo-controlled study that aimed to determine the impact of green coffee (GC) in obese patients with metabolic syndrome through analysis of miRNA-155, miRNA-133a and the inflammatory biomarkers such as resistin, TNF-α, total sialic acid, homocysteine, high sensitivity C-reactive protein (hs-CRP), and the anti-inflammatory cytokine, adiponectin.

Methods: One hundred-sixty obese patients were randomly supplemented either with GC capsules (800 mg) or placebo daily for six months.

Efficacy of virtual reality on balance impairment in ataxic cerebral palsy children: randomized controlled trial.

Background: Children with ataxic cerebral palsy have unsteady movements and poor balance. Many therapeutic interventions are used to improve their upper and lower functioning.

Aim: To assess the effectiveness of virtual reality (VR) on balance impairment in ataxic cerebral palsy children.

An in vitro evaluation of tensile strength of molar endocrown milled from various computer aided design and manufacturing materials.

New computer-aided design and computer-aided manufacturing (CAD-CAM) materials have been reported to have suitable mechanical and physical properties for endocrown restorations. However, there is a lack of literature on evaluating the retention of endocrown using these materials. This in vitro study aimed to compare the retention of endocrowns fabricated from 3 different CAD-CAM materials.

Physical/mechanical and antibacterial properties of composite resin modified with selenium nanoparticles.

Background: Accumulation of biofilm over composite resin restorations is one of the principal causes of recurrent caries. Therefore, this study aimed to develop antibacterial composite resins by crystalline selenium nanoparticles (SeNPs), assessing the antibacterial, mechanical, and physical properties of the composite resin after SeNPs incorporation.

Methods: SeNPs were synthesized via a green method.

Utility of Microwave-Synthesized Silver Nano Particles as Spectrofluorimetric Sensors for the Determination of Nano Concentrations of Favipravir: Application to Dosage Forms and Spiked Human Plasma.

A simple and facile microwave-assisted method was developed for the synthesis of highly fluorescent silver-nanoparticles (Ag-NPs). The synthesis of silver-nanoparticles depends on a redox reaction between silver nitrate and ascorbic acid using chitosan as a stabilizing agent. The produced Ag-NPs were characterized using Zeta potential and transmission electron microscope micrograph where they are spherical in shape with smooth surface morphology and size of 26.