512 results match your criteria: "Delaware State University.[Affiliation]"

A Review of Transparent Conducting Films (TCFs): Prospective ITO and AZO Deposition Methods and Applications.

Nanomaterials (Basel)

December 2024

Division of Physics, Engineering, Mathematics and Computer Sciences and Optical Science Center for Applied Research, Delaware State University, Dover, DE 19901, USA.

This study offers a comprehensive summary of the current states as well as potential future directions of transparent conducting oxides (TCOs), particularly tin-doped indium oxide (ITO), the most readily accessible TCO on the market. Solar cells, flat panel displays (FPDs), liquid crystal displays (LCDs), antireflection (AR) coatings for airbus windows, photovoltaic and optoelectronic devices, transparent p-n junction diodes, etc. are a few of the best uses for this material.

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Unlike lipid stability and oxidation studies in commonly used edible oils and margarines, margarines formulated with unconventional oils are not well characterized. This study investigated the effect of heat treatment (HT) on the stability and content of phytosterol in njangsa seed oil (NSO), bush mango oil (BMO), soybean oil (SBO), coconut oil (CCO), and margarines formulated from their blends: BN (BMO and NSO), BS (BMO and SBO), CN (CCO and NSO), CS (CCO and SBO), and commercial margarines (CM1 and CM2). Both oils and margarines were heat-treated at 130, 170, and 210°C for 10, 15, 20, and 120 min (only oils).

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Article Synopsis
  • Pediatric renal cell carcinoma (pRCC) is a rare, aggressive cancer in children with lower survival rates compared to other pediatric cancers, influenced by factors like sex, race, ethnicity, age, and socio-economic status.
  • A retrospective study analyzed 174 pRCC cases from 1973 to 2015 to understand survival rates, identifying significant disparities, such as black/AA children being nearly three times more likely to die from the disease than white children.
  • The study highlights the need for further research into socio-economic and demographic factors affecting pRCC outcomes, as well as exploring insufficiently studied determinants like area of residence.
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Monitoring and tracking of cell motion is a key component for understanding disease mechanisms and evaluating the effects of treatments. Time-lapse optical microscopy has been commonly employed for studying cell cycle phases. However, usual manual cell tracking is very time consuming and has poor reproducibility.

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Article Synopsis
  • SARS-CoV-2 mutates over time, leading to new Variants of Concern (VOCs) that can affect how easily the virus spreads, the severity of illness, and how well current antiviral drugs work.
  • Recent antiviral drugs like Nirmatrelvir and Ensitrelvir inhibit specific viral proteins (3CLpro), while others like Remdesivir target different proteins (nsp12), but resistance mutations may diminish their effectiveness.
  • The review outlines key mutations in these viral proteins and discusses recent advancements in antiviral treatments, highlighting the concern of developing resistance as new variants emerge.
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Objective: To assess racial and sex variances in second primary thyroid malignancy (SPTM) cumulative incidence and temporal trends and the radiation exposure effect in pediatric SPTM.

Materials And Methods: A retrospective cohort study, a non-experimental epidemiologic design, was used to assess the cumulative incidence (CmI) and temporal trends as well as the exposure effect of radiation in SPTM among children, 0-19 years, in the Surveillance, Epidemiology, and End Results (SEER) registry, National Cancer Institute (NCI), USA. Percent change (PC) and annual percent change (APC) were used to examine CmI rates and temporal trends, while chi-square statistics and binomial regression models were used to examine variable distribution by race and to determine the exposure effect of radiation on SPTM as well as mortality, respectively.

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The COVID-19 pandemic officially started in March 2020 and ended in May 2023. Preventive behaviors have been proven to be one of the most effective strategies for preventing COVID-19 transmission. Common preventive behaviors against COVID-19 include but are not limited to wearing a face mask, washing and sanitizing one's hands frequently, avoiding crowds, and avoiding traveling.

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Article Synopsis
  • Frequent consumption of fermented carbohydrates and bottle feeding are linked to early childhood caries (ECC), but breastfeeding's impact on children's oral health remains unclear in the U.S.
  • A study using a national survey sampled 24,655 parents of children aged 6 months to 5 years to investigate the relationship between exclusive breastfeeding for the first 6 months and oral health disorders (OHD).
  • Results showed that exclusive breastfeeding was initially associated with a lower likelihood of OHD, but this relationship lost significance after adjusting for factors like maternal health and race, with notable disparities in OHD prevalence observed across different ethnic groups.
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Background: Neighborhood-level adverse social determinants may be a risk factor for sleep health disparities. We examined the associations between neighborhood factors and insomnia and explored their spatial clustering in the city of Philadelphia, Pennsylvania.

Methods: We conducted a cross-sectional analysis of data from Philadelphia residents who participated in online screening for insomnia-related research.

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Thin Conducting Films: Preparation Methods, Optical and Electrical Properties, and Emerging Trends, Challenges, and Opportunities.

Materials (Basel)

September 2024

Division of Physics, Engineering, Mathematics and Computer Sciences, and Research on Nanomaterial-Based Integrated Circuits and Electronics (NICE), Delaware State University, Dover, DE 19901, USA.

Thin conducting films are distinct from bulk materials and have become prevalent over the past decades as they possess unique physical, electrical, optical, and mechanical characteristics. Comprehending these essential properties for developing novel materials with tailored features for various applications is very important. Research on these conductive thin films provides us insights into the fundamental principles, behavior at different dimensions, interface phenomena, etc.

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The research on two-dimensional materials has gained significant traction due to their potential for thermoelectric, optical, and other properties. The development of two-dimensional (2D) nanostructured-based TE generators and photodetectors has shown promising results. Over the years, researchers have played a crucial role in advancing this field, enhancing the properties of 2D materials through techniques such as doping, alloying, and various growth methods.

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CHARMM at 45: Enhancements in Accessibility, Functionality, and Speed.

J Phys Chem B

October 2024

Harvard University, Department of Chemistry and Chemical Biology, Cambridge, Massachusetts 02138, United States.

Since its inception nearly a half century ago, CHARMM has been playing a central role in computational biochemistry and biophysics. Commensurate with the developments in experimental research and advances in computer hardware, the range of methods and applicability of CHARMM have also grown. This review summarizes major developments that occurred after 2009 when the last review of CHARMM was published.

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Considering p53's pivotal role as a tumor suppressor protein, proactive identification and characterization of potentially harmful p53 mutations are crucial before they appear in the population. To address this, four computational prediction tools-SIFT, Polyphen-2, PhD-SNP, and MutPred2-utilizing sequence-based and machine-learning algorithms, were employed to identify potentially deleterious p53 nsSNPs (nonsynonymous single nucleotide polymorphisms) that may impact p53 structure, dynamics, and binding with DNA. These computational methods identified three variants, namely, C141Y, C238S, and L265P, as detrimental to p53 stability.

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Purpose: Segmentation is essential for tissue quantification and characterization in studies of aging and age-related and metabolic diseases and the development of imaging biomarkers. We propose a multi-method and multi-atlas methodology for automated segmentation of functional muscle groups in three-dimensional (3D) thigh magnetic resonance images. These groups lie anatomically adjacent to each other, rendering their manual delineation a challenging and time-consuming task.

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Age is a major predictor of developmental processes and disease risk, but humans and model systems (e.g., mice) differ substantially in the pace of development and aging.

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Functional Lipids and Cardiovascular Disease Reduction: A Concise Review.

Nutrients

July 2024

Department of Food and Nutritional Sciences, Tuskegee University, 1200 W. Montgomery Rd, Tuskegee, AL 36088, USA.

Functional lipids are dietary substances that may have an impact on human health by lowering the risk of chronic illnesses and enhancing the quality of life. Numerous functional lipids have been reported to have potential health benefits in the prevention, management, and treatment of cardiovascular disease, the leading cause of death in the United States. However, there is still insufficient and contradictory information in the literature about their effectiveness and associated mechanisms of action.

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Salt marsh grass () plays a crucial role in Delaware coastal regions by serving as a physical barrier between land and water along the inland bays and beaches. This vegetation helps to stabilize the shoreline and prevent erosion, protecting the land from the powerful forces of the waves and tides. In addition to providing a physical barrier, salt marsh grass is responsible for filtering nutrients in the water, offering an environment for aquatic species and presenting a focal point of study for high salt tolerance in plants.

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Electrical, Optical and Thermal Properties of Ge-Si-Sn-O Thin Films.

Materials (Basel)

July 2024

Division of Physics, Engineering, Mathematics and Computer Science, and Optical Science Center for Applied Research, Delaware State University, Dover, DE 19901, USA.

This work evaluates the electrical, optical and thermal properties of Sn-doped GeSiO thin films for use as microbolometer sensing materials. The films were prepared using a combination of a radio frequency (RF) magnetron and direct current (DC) sputtering using a Kurt J Leskar Proline PVD-75 series sputtering machine. Thin films were deposited in an O+Ar environment at a chamber pressure of 4 mTorr.

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Genetic and epigenetic signatures for improved breeding of cultivated blueberry.

Hortic Res

July 2024

Jilin Provincial Laboratory of Crop Germplasm Resources, College of Horticulture, Jilin Agricultural University, No. 2888 Xincheng Street, Economic Development District, Changchun 130118, China.

Article Synopsis
  • Blueberry is an economically important fruit that was domesticated in the early 1900s through hybridization, with the research including 220 accessions from multiple countries.
  • The study focused on identifying genetic traits that differentiate northern highbush blueberries (NHB) from southern highbush blueberries (SHB), revealing specific genes linked to climate adaptability and fruit quality.
  • Whole-genome sequencing and analysis indicated significant genetic variation and epigenetic differences, particularly in the β-alanine metabolic pathway, providing essential resources for future blueberry breeding efforts.
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Chemical information has become increasingly ubiquitous and has outstripped the pace of analysis and interpretation. We have developed an R package, uafR, that automates a grueling retrieval process for gas -chromatography coupled mass spectrometry (GC -MS) data and allows anyone interested in chemical comparisons to quickly perform advanced structural similarity matches. Our streamlined cheminformatics workflows allow anyone with basic experience in R to pull out component areas for tentative compound identifications using the best published understanding of molecules across samples (pubchem.

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Understanding the Perception of Place and Its Impact on Community Violence.

Dela J Public Health

June 2024

Professor of Political Science and Chair of the Department of Political Science, Jackson State University.

In this article, we explore the responses of 357 African American men between 15- and 24-years old living in four high crime high violence cities to better understand their perception of their environment and its impact on community violence. We focus on study participants' perceptions of their cities, explanations of violence, and their perceived contribution to the level of violence. Respondents describe their cities in grim terms with few opportunities.

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It Takes a Village: Moving from Unaligned Action to Collective Impact.

Dela J Public Health

June 2024

Director, Center for Neighborhood Revitalization and Research, Delaware State University.

For over two decades, violence has been understood as a public health problem. Despite a well-established and applicable public health framework, progress to address the entrenched violence that plagues many cities has been slow. We believe that progress can be effective only if it fully includes those most impacted by the violence.

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The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a global COVID-19 pandemic, challenging healthcare systems worldwide. Effective therapeutic strategies against this novel coronavirus remain limited, underscoring the urgent need for innovative approaches. The present research investigates the potential of cannabis compounds as therapeutic agents against SARS-CoV-2 through their interaction with the virus's papain-like protease (PLpro) protein, a crucial element in viral replication and immune evasion.

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PET Imaging of Neurofibromatosis Type 1 with a Fluorine-18 Labeled Tryptophan Radiotracer.

Pharmaceuticals (Basel)

May 2024

Nemours Biomedical Research, Nemours Children's Health, Delaware, Wilmington, DE 19803, USA.

Neurofibromatosis type 1 (NF1) is a neurocutaneous disorder. Plexiform neurofibromas (PNFs) are benign tumors commonly formed in patients with NF1. PNFs have a high incidence of developing into malignant peripheral nerve sheath tumors (MPNSTs) with a 5-year survival rate of only 30%.

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Adverse childhood experiences (ACEs) include a range of abusive, neglectful, and dysfunctional household behaviors that are strongly associated with long-term health problems, mental health conditions, and societal difficulties. The study aims to uncover significant factors influencing ACEs in children aged 0-17 years and to propose a predictive model that can be used to forecast the likelihood of ACEs in children. Machine learning models are applied to identify and analyze the relationships between several predictors and the occurrence of ACEs.

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