Mechanical Behaviour and Microstructural Analysis of Earthen Materials Reinforced with Intensive Agricultural By-Products and Binders.

Modern construction is largely dependent on steel and concrete, with natural materials such as earth being significantly underutilised. Despite its sustainability and accessibility, earth is not being used to its full potential in developed countries. This study explores innovative building materials using Alhambra Formation soil (Granada, Spain) reinforced with difficult-to-recycle agricultural waste: polypropylene fibres contaminated with organic matter and leachates.

Ant-Plant Mutualism in Palm Peat Swamp Forests: A Study of Host and Epiphyte Diversity in Ant Gardens.

Mutualisms characterized by reciprocal benefits between species are a fundamental relationship of tropical ecosystems. Ant Gardens (AGs) represent an interesting ant-plant mutualism, involving specialized interactions between vascular epiphytes and ants. While this relationship has been extensively studied in various tropical regions, the available information on Peruvian ecosystems is limited.

De Novo miRNAs from (Hymenoptera: Pteromalidae) Conserved in the Order Hymenoptera.

The parasitoid wasp (Howard) (Hymenoptera: Pteromalidae) has the potential for biological control against insect pests in stored grains, mainly of the orders Coleoptera and Lepidoptera. microRNAs (miRNAs) are small non-coding RNA fragments of importance in the regulation of gene translation in most physiological processes, and the study of miRNAs in wasps can be useful for understanding the physiology of these insects. The objective of this study was to evaluate for the first time the miRNomic profile of and to determine its conservation in five species of the order Hymenoptera (, , , and ).

Silencing Gene with dsRNA of Different Lengths Impairs Larval Development in .

In the search for effective strategies to control the Colorado Potato Beetle, RNA interference technology has emerged as a promising method due to its capacity to suppress genes selectively. Factors such as the target gene and double-stranded RNA (dsRNA) length are critical for optimizing gene silencing efficiency. In this study, we designed and synthesized in vitro dsRNAs of varying lengths targeting the gene, which encodes the AChE1 isoform of acetylcholinesterase in the beetle.

Recommendations for Implementing Innovative Technologies to Control : Population Suppression Using a Combination of the Incompatible and Sterile Insect Techniques (IIT-SIT), Based on the Mexican Experience/Initiative.

The future of control emphasizes the transition from traditional insecticides toward more sustainable and multisectoral integrated strategies, like using -carrying mosquitoes for population suppression or replacement. We reviewed the integration of the successful Mexican initiative, "Mosquitos Buenos", with the key challenges outlined in the PAHO guidelines for incorporating innovative approaches into vector control programs. These challenges include establishing essential infrastructure, training personnel, managing field operations, and fostering community support.

The Dynamics of Pheromone Release in Two Passive Dispensers Commonly Used for Mating Disruption in the Control of and in Vineyards.

Background: Mating disruption (MD) is a worthwhile technique for the control of and in central Europe and Mediterranean areas. MD efficacy is affected by the pheromone release (PR), which in turn is influenced by environmental conditions.

Methods: The effect of weather conditions on PR was evaluated under four different fields in northern Italy.

MET Exon 14 Skipping and Novel Actionable Variants: Diagnostic and Therapeutic Implications in Latin American Non-Small-Cell Lung Cancer Patients.

Targeted therapy indications for actionable variants in non-small-cell lung cancer (NSCLC) have primarily been studied in Caucasian populations, with limited data on Latin American patients. This study utilized a 52-genes next-generation sequencing (NGS) panel to analyze 1560 tumor biopsies from NSCLC patients in Chile, Brazil, and Peru. The RNA sequencing reads and DNA coverage were correlated to improve the detection of the actionable exon 14 skipping variant (METex14).

Different Cytotoxic Effects of Cisplatin on Pancreatic Ductal Adenocarcinoma Cell Lines.

This study examined the response to cisplatin in BxPC-3, Mia-Paca-2, PANC-1, and YAPC pancreatic cancer lines with different genotypic and phenotypic characteristics, and the mechanisms associated with their resistance. BxPC-3 and MIA-PaCa-2 cell lines were the most sensitive to cisplatin, while YAPC and PANC-1 were more resistant. Consistently, in cisplatin-treated BxPC-3 cells, the cleavage patterns of pro-caspase-9, -7, -3, and PARP-1 demonstrated that they were more sensitive than YAPC cells.

Sucralose-Enhanced Adipogenesis on Preadipocyte Human Cell Line During Differentiation Process.

Sucralose, a commonly nonnutritive sweetener used in daily products of habitual diet, is related to impairing the gut microbiome by disrupting inflammatory response, promoting weight gain by increasing adipose tissue and promoting chronic inflammatory processes. Considering the impact of sucralose in the development of metabolic diseases, in this work, we focused on the impact of sucralose on the adipocyte differentiation process to determine if sucralose can promote adipogenesis and increase adipose tissue depots in PCS 210 010 human preadipocytes cell line. Sucralose at 25 (S25) and 100 ng/µL (S100) concentrations were tested against control with no edulcorant (NS) during the adipocyte differentiation process at 48 h and 96 h.

Molecular Detection of Lymph Node Metastases with One-Step Nucleic Acid Amplification (OSNA) Pooling in Prostate Cancer: The POPCORN Study.

Pelvic lymph node dissection (PLND) is the most accurate procedure for lymph node (LN) staging in prostate cancer (PCa) patients. LN sectioning and hematoxylin and eosin (H&E) staining of at least one slice remains the gold standard for LN evaluation, potentially leading to misdetection of small metastatic focus. Entire LN analysis is possible with One-Step Nucleic Acid Amplification (OSNA) by detecting cytokeratin 19 (CK19) mRNA as a surrogate for LN invasion.

Trehalose Interferes with the Photosynthetic Electron Transfer Chain of Permeating the Bacterial Chromatophore Membrane.

Disaccharide trehalose has been proven in many cases to be particularly effective in preserving the functional and structural integrity of biological macromolecules. In this work, we studied its effect on the electron transfer reactions that occur in the chromatophores of the photosynthetic bacterium . In the presence of a high concentration of trehalose, following the activation of the photochemistry by flashes of light, a slowdown of the electrogenic reactions related to the activity of the photosynthetic reaction center and cytochtome (cyt) complexes is observable.

Association Between Common Variants in the / Genes and Risk for Essential Tremor.

Many clinical, neuroimaging, neuropathological, epidemiological, and genetic data suggest a relationship between essential tremor (ET) and Parkinson's disease (PD). Several hypothesis-based gene association studies attempted to find a genetic association between these diseases. Recent case-control association studies in Chinese and Spanish populations showed a marginal association between the rs1922452 and rs951818 single nucleotide variants (SNVs) and the risk of PD.

Imaging-Based Molecular Interaction Between Src and Lamin A/C Mechanosensitive Proteins in the Nucleus of Laminopathic Cells.

Laminopathies represent a wide range of genetic disorders caused by mutations in gene-encoding proteins of the nuclear lamina. Altered nuclear mechanics have been associated with laminopathies, given the key role of nuclear lamins as mechanosensitive proteins involved in the mechanotransduction process. To shed light on the nuclear partners cooperating with altered lamins, we focused on Src tyrosine kinase, known to phosphorylate proteins of the nuclear lamina.

Caryophyllene Oxide, a Bicyclic Terpenoid Isolated from with Antitumor Activity: In Vivo, In Vitro, and In Silico Studies.

The Annona genus contains some species used in Mexican traditional medicine for the treatment cancer, including . The present study aimed to investigate the anticancer activity of caryophyllene oxide (CO) isolated from using in vivo, in vitro, and in silico approaches. The identification of CO was performed using gas chromatography-mass spectroscopy and NMR methods.

Faecal Metabolome Profiles in Individuals Diagnosed with Hyperplastic Polyps and Conventional Adenomas.

Colorectal cancer (CRC) development is a gradual process in which progressive histological alterations of the intestinal mucosa damage occur over years. This process can be influenced by modifiable external factors such as lifestyle and diet. Most CRC cases (>80%) originate from conventional adenomas through the adenomatous pathway and usually harbour dysplastic cells, whereas the serrated pathway is less frequent (<20% cases) and comprises hyperplastic polyps and other polyps containing dysplastic cells.

Bioassay-Guided Fractionation Networking for Discovery of Biofungicides from Cultivated .

Considering the detrimental impacts of the current pesticides on the biotic components of the biosphere, the development of novel pesticides is vital. Plant-derived biopesticides have emerged as popular alternatives to create a safer and more sustainable agriculture model. This study aims to validate the previous bioguided fractionation of endemic Canary Islands sage, , as a potential source of botanical pesticides using a cultivation process.

Study of Photodegradation of Bentazon Herbicide by Using ZnO-SmO Nanocomposite Under UV Light.

The removal of organic pollutants from water is significantly important as they have harmful effects on the ecosystem. Heterogeneous photocatalysis is a potential technique for the removal of organic pollutants from the wastewater. In this article, zinc oxide (ZnO) and samarium oxide (SmO) nanoparticles and ZnO-SmO nanocomposite (ZS) were synthesized by the co-precipitation method.

Study of Microbiota Associated to Early Tumors Can Shed Light on Colon Carcinogenesis.

An increasingly important role for gut microbiota in the initiation and progression of colorectal cancer (CRC) has been described. Even in the early stages of transformation, i.e.

Uric Acid Correlates with Serum Levels of Mineral Bone Metabolism and Inflammation Biomarkers in Patients with Stage 3a-5 Chronic Kidney Disease.

: Uric acid (UA) and the markers of mineral bone metabolism and inflammation are commonly altered in patients with chronic kidney disease (CKD) and are associated with the risk of cardiovascular complications and death. Studies point to a link between high serum UA and mineral bone homeostasis and inflammation, but controversy remains. The aim of this study was to evaluate the relationship between UA levels and mineral bone metabolism and inflammation biomarkers in a sample of Mexican patients with CKD 3a-5.

Return to Performance of a Soccer Player with an Adductor Longus Injury: A Case Report.

There is limited information on the quantification of external load and reconditioning programs during adductor longus injuries in soccer. This case report describes a male professional soccer player () returning to performance following an adductor longus muscle injury during the 2022/2023 season. The player suffered the injury during a change of direction in a match.

Functional Rehabilitation in Non-Reconstructed Hemimandibulectomy Patients.

Functional rehabilitation in patients with hemimandibulectomy remains a challenge no matter what method of reconstruction is chosen by physicians. In this paper, we aim to evaluate the feasibility of an acceptable occlusal restoration in patients who have undergone hemimanidublectomy without the reestablishment of mandibular continuity. Data were collected retrospectively on 10 patients with varying degrees of mandible resection.

Prediction Model for Sciatic Nerve Procedures: A Cross-Sectional Study.

We aimed to create a predictive model to estimate sciatic nerve depth using anthropometric and demographic data to enhance safety and precession in needle-based interventions. Setting: The study was conducted at Universidad Europea de Madrid, Spain. A Cross-sectional observational study was carried out between January and April 2024.

Retinal Vascular Complications in Cocaine Abuse: A Case Report and a Literature Review.

This comprehensive review examines the ocular vascular complications of cocaine use, focusing on its effects on retinal vasculature and inflammation. A rare case of bilateral frosted branch angiitis (FBA) in a 48-year-old man with a history of intranasal cocaine abuse is presented as an illustrative example to stimulate discussion. The case highlights severe retinal ischemia and vascular sheathing, with no identifiable infectious or autoimmune cause, ultimately complicated by systemic vascular events.

Remimazolam Versus Propofol in General Anesthesia of Complex Surgery in Critical and Non-Critical Patients: Meta-Analysis of Randomized Trials.

: To compare the efficacy and safety of remimazolam with propofol in general anesthesia in adult patients. : A systematic search in Pubmed, Scopus, Web of Science, and Embase was performed. Patients undergoing complex surgery who were critically ill or non-critically ill were included.