Disease management teams in oncology: State of the art and the experience of a scientific institute of hospitalization and treatment (IRCCS) in Rome, Italy.

Background: This article analyzes the main coordination needs linked to the diagnosis and treatment of oncological diseases, presenting the various integration tools that our healthcare organization adopted to guarantee continuity of care at the IRCCS IFO (Istituto di Ricovero e Cura a Carattere Scientifico Istituti Fisioterapici Ospitalieri) in Rome. The object of investigation is the disease management team (DMT) organization for the diagnosis and treatment of people suffering from oncological disease and the consequences in terms of improving their management.

Methods: The study focuses, in particular, on the analysis of the different organizational methods chosen for the management of activities related to diagnosis and treatment paths.

An Unexpected Outcome of an Ischemic Stroke on the Reward Pathways in the Human Brain.

Background: Addiction affects millions of people, often resulting from a complex interplay between genetic and environmental factors, and is frequently linked to mental health disorders. Many experts agree there is no cure for addiction, but there are effective treatments available. Many patients continue to succumb to addiction despite treatment.

Dissociation Between Measures of Macrocirculation and Microcirculation in Patients Undergoing Cardiac Surgical Procedure.

Background: In the postoperative period of cardiac surgical procedure, there is an imbalance in the ratio of oxygen supply to oxygen consumption that leads to organic dysfunction and death. There is evidence of microcirculation involvement in cardiac surgical procedure, and a dysregulated inflammatory response similar to sepsis can occur.

Methods: We present a cohort of 280 consecutive adults who were monitored in the postoperative period after cardiac surgical procedure.

Development of a Novel Intraperitoneal Icodextrin/Dextrose Solution for Enhanced Sodium Removal.

Rationale & Objective: Peritoneal dialysis (PD) solutions provide both clearance of uremic toxins and sodium and water. An intraperitoneal (IP) solution of icodextrin and glucose designed without the requirement for uremic toxin clearance could provide substantially greater sodium and water removal than PD solutions.

Study Design: We examined varying concentrations of icodextrin and dextrose IP solutions in rats.

Serum Lidocaine Levels in Adult Patients Undergoing Cardiac Surgery With del Nido Cardioplegia.

Background: Lidocaine in del Nido cardioplegia solution prolongs the refractory period of cardiomyocytes, yielding a longer arrest per dose. Serum lidocaine concentrations >8 mg/L are associated with seizure and cardiotoxicity. We evaluated serum lidocaine concentrations in patients receiving del Nido solution during cardiac surgery.

Cut-Off Points for Low Relative 30-s Sit-to-Stand Power and Their Associations With Adverse Health Conditions.

Background: Despite muscle power derived from the 5-rep sit-to-stand (STS) test having been demonstrated to be a valuable biomarker in older individuals, there is limited information regarding muscle power derived from the 30-s STS test, a widely used test in the clinical setting. This study aimed (i) to compare relative 30-s STS power values between older men and women, (ii) to identify cut-off points for low relative 30-s STS power, (iii) to compare the prevalence of low relative STS power between sexes and (iv) to evaluate the association of low relative 30-s STS power with adverse conditions in older people.

Methods: A total of 1475 community-dwelling older adults (65-98 years; 45% men) from the Toledo Study for Healthy Aging were included.

Allostatic Load as a Short-Term Prognostic and Predictive Marker.

It would be highly valuable to possess a tool for evaluating disease progression and identifying patients at risk of experiencing a more severe clinical course and potentially worse outcomes. The concept of allostatic load, which represents the overall strain on the body from repeated stress responses, has been recognized as a precursor to the development of chronic illnesses. It functions as a cumulative measure of the body's capacity to adapt to stress.

Percutaneous closure of a traumatic ventricular septal defect: a case report and literature review.

Background: Penetrating cardiac trauma is an entity with high pre and intrahospital mortality due to complications such as cardiac tamponade and massive hemothorax. A ventricular septal defect (VSD) occurs in 1-5% of cases and can present early or late. The management strategy for VSD resulting from penetrating cardiac trauma is uncertain.

No winter halt in below-ground wood growth of four angiosperm deciduous tree species.

In the temperate zone, deciduous trees exhibit clear above-ground seasonality, marked by a halt in wood growth that represents the completion of wood formation in autumn and reactivation in spring. However, the growth seasonality of below-ground woody organs, such as coarse roots, has been largely overlooked. Here we use tree monitoring data and pot experiments involving saplings to examine the late-season xylem development of stem and coarse roots with leaf phenology in four common deciduous tree species in Western Europe.

Silver nanoparticles coated with metabolites of Pseudomonas sp. N5.12 inhibit bacterial pathogens and fungal phytopathogens.

The synthesis of nanomaterials from PGPB is an exciting approach and it's often used in agriculture as nano-fertilizers and nano-pesticides. The present study reports a new approach to biosynthesis of silver nanoparticles (AgNP), using bacterial metabolites as agents to reduce Ag, which will remain as coating agents able to prevent microbial growth. Silver NP were biosynthesized using the bacterial metabolites produced by the beneficial strain Pseudomonas sp.

Socioeconomic status correlates with COVID-19 vaccination coverage among primary and secondary students in the most populated city of Chile.

The burden of COVID-19 was heterogeneous, indicating that the effects of this disease are synergistic with both other non-communicable diseases and socioeconomic status (SES), highlighting its syndemic character. While the appearance of vaccines moderated the pandemic effects, their coverage was heterogeneous too, both when comparing different countries, and when comparing different populations within countries. Of note, once again SES appears to be a correlated factor.

Tip-to-base bark cross-sectional areas contribute to understanding the drivers of carbon allocation to bark and the functional roles of bark tissues.

Along their lengths, stems experience different functional demands. Because bark and wood traits are usually studied at single points on stems, it remains unclear how carbon allocation changes along tip-to-base trajectories across species. We examined bark vs wood allocation by measuring cross-sectional areas of outer and inner bark (OB and IB), IB regions (secondary phloem, cortex, and phelloderm), and wood from stem tips to bases of 35 woody angiosperm species of diverse phylogenetic lineages, climates, fire regimes, and bark morphologies.

Structure-Reactivity Relationship of Zeolite-Confined Rh Catalysts for Hydroformylation of Linear α-Olefins.

Substituting the molecular metal complexes used in the industrial olefin hydroformylation process is of great significance in fundamental research and practical application. One of the major difficulties in replacing the classic molecular metal catalysts with supported metal catalysts is the low chemoselectivity and regioselectivity of the supported metal catalysts because of the lack of a well-defined coordination environment of the metal active sites. In this work, we have systematically studied the influences of key factors (crystallinity, alkali promoters, etc.

Blending deep-learning and observers for improved state of charge estimation in vanadium flow batteries.

This paper presents the design and implementation of a deep-learning-based observer for accurately estimating the State of Charge (SoC) of a vanadium flow battery. The novelty of the proposal lies in its direct use of terminal voltage and the application of a machine learning algorithm to model the battery's overpotentials, leading to greater accuracy and reduced complexity compared to classical models. The overpotentials model consists of a neural network trained using data generated by a classical observer that estimates species concentration using a physical electrochemical model and the open-circuit voltage measurement.

CASR, CLDN 14, ALPL & SLC34A1 genes are associated with the risk of nephrolithiasis in Egyptian children.

Backgrounds: The pathophysiology of nephrolithiasis is complex, influenced by both environmental and genetic factors. Calcium is the most prevalent metabolite present in the stone matrix. Stimulating the basolateral calcium sensing receptor (CASR) in the renal tubules leads to an increase in claudin-14 expression, reducing paracellular calcium permeability and increasing urinary Ca excretion.

Reduction of postoperative ileus in gastrointestinal surgery. Systematic review and meta-analysis.

Background: Postoperative ileus is a surgical complication that affects intestinal motility. There are measures to reduce this problem, but not all have conclusive current evidence.

Objective: To determine which measures such as coffee, chewing gum, electro-acupuncture, Daikenchuto (DKT) and prokinetic agents are most effective in reducing postoperative ileus in patients undergoing gastrointestinal surgeries.

Serological evidence of Crimean-Congo haemorrhagic fever in domestic animals from eight regions of Namibia.

Crimean-Congo haemorrhagic fever (CCHF) is a viral zoonotic disease endemic to regions of Africa, the Balkans, the Middle East, and Asia, with increasing reports of cases in southern Europe. Human transmission occurs primarily through the bite of infected ticks and by body fluids from infected human. Crimean-Congo haemorrhagic fever virus (CCHFV) affects a broad host range, including both domestic and wild vertebrates.