A novel LC-TQ-MS/MS method for quantifying mefenamic acid-NDSRI (N-nitroso drug substance-related impurity) in mefenamic acid tablet and pediatric suspension dosage forms: a comparative study with a cost-effective white, green, and blue UPLC method.

The current research presents novel LC-TQ-MS/MS and cost-effective UPLC methods intended for the accurate quantification of mefenamic acid-N-nitroso drug substance-related impurity-NDSRI (N-MFA) in mefenamic acid (MFA) tablet and pediatric suspension dosage forms. The acceptable intake of N-MFA is derived from the TD50 (Median Toxic Dose-50%) value of N-nitroso diphenylamine. The analytical separation was achieved for the UPLC method using an XBridge BEH Shield RP18 Column (150 × 3.

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Globally, industrial biotechnology addresses diverse challenges, fostering environmental conservation, sustainable development, economic growth, and innovation. Currently, there are approximately 20,922 biotech companies worldwide, including 6,653 in the US, reflecting significant growth. The global biotech market is valued at $727.

"Brij 35 inhibited the CYP2E1-mediated metabolism and P-gp mediated transport of Paracetamol in rats and models: Amelioration of Paracetamol Toxicity.

The harmful by-product of paracetamol is known as N-Acetyl-p-benzoquinoneimine, (NAPQI). When paracetamol is given at therapeutic dosages or in excess, it undergoes Phase I metabolism in the liver via Cytochrome P-450 2E1 (CYP2E1), and then it produces NAPQI. Previous studies reported that a non-ionic surfactant known as Brij 35 (Polyoxyethylene lauryl ether) has been shown to be an effective inhibitor of CYP2E1 and P-glycoprotein (P-gp).

In Situ Slow-Release Hydrogen Sulfide Therapeutics for Advanced Disease Treatments.

Hydrogen sulfide (HS) gas therapygarners significant attention for its potential to improve outcomes in various disease treatments. The quantitative control of HS release is crucial for effective the rapeutic interventions; however, traditional researchon HS therapy frequently utilizes static release models and neglects the dynamic nature of blood flow. In this study, we propose a novel slow-release in-situ HS release model that leverages the dynamic hydrolysis of HS donorswithin the bloodstream.

Minimal sourced and lightweight federated transfer learning models for skin cancer detection.

One of the most fatal diseases that affect people is skin cancer. Because nevus and melanoma lesions are so similar and there is a high likelihood of false negative diagnoses challenges in hospitals. The aim of this paper is to propose and develop a technique to classify type of skin cancer with high accuracy using minimal resources and lightweight federated transfer learning models.

AI-based hybrid power quality control system for electrical railway using single phase PV-UPQC with Lyapunov optimization.

This research paper presents an advanced AI-driven hybrid power quality management system for electrical railways that addresses critical challenges in 25 kV AC traction networks through a novel integration of single-phase PV-UPQC with ANN-Lyapunov control architecture. The system effectively manages voltage unbalance exceeding 2%, high THD, voltage variations of ± 10%, and poor power factor through a dual-approach methodology combining ANN-based reference signal generation with Lyapunov optimization, enabling dynamic parameter tuning and real-time load adaptation. MATLAB/Simulink simulations validate the system's superior performance, demonstrating significant improvements, including voltage unbalance reduction from 1.

Coexisting pilonidal sinus and anal fistula: Successful management with minimal invasive Kshara Karma Technique and Ksharasutra therapy- A case report.

Pilonidal sinus (PNS) is a nest of hair which typically presents as pits, pus discharge, and an abscess at the natal cleft region. In rare conditions where pilonidal abscess is not drained properly, it progresses posteriorly and reaches anal canal, eventually coexisting with anal fistula. Both are associated with a high recurrence rate despite surgical management.

Silymarin: a promising modulator of apoptosis and survival signaling in cancer.

Cancer, one of the deadliest diseases, has remained the epicenter of biological research for more than seven decades. Yet all the efforts for a perfect therapeutic cure come with certain limitations. The use of medicinal plants and their phytochemicals as therapeutics has received much attention in recent years.

Association Between SHBG Levels and Hypertensive Disorders of Pregnancy: A Systematic Review and Meta-Analysis.

Sex hormone-binding globulin (SHBG) regulates sex hormone availability and is influenced by metabolic factors. Variations in SHBG levels during pregnancy may affect the development of hypertensive disorders such as gestational hypertension (GH) and preeclampsia (PE). This systematic review and meta-analysis explores the potential of SHBG as a biomarker for predicting GH and PE.

Coati optimization algorithm for brain tumor identification based on MRI with utilizing phase-aware composite deep neural network.

Brain tumors can cause difficulties in normal brain function and are capable of developing in various regions of the brain. Malignant tumours can develop quickly, pass through neighboring tissues, and extend to further brain regions or the central nervous system. In contrast, healthy tumors typically develop slowly and do not invade surrounding tissues.

Formulation and Evaluation of Lipid/Soluplus-Stabilized Nanocrystals of Paclitaxel and Bosutinib for a Synergistic Effect in Non-Small Cell Lung Cancer Therapy.

Tyrosine kinase inhibitors have been employed for the treatment of lung cancer, owing to their role in regulating irregulated pathways or mutated genes. Bosutinib, a nonreceptor tyrosine kinase, has been recently investigated for lung cancer treatment. Bosutinib can also be used with paclitaxel as a combinatorial approach to receive a synergistic effect for the effective management of lung cancer.

Production and characterization of sophorolipid under yeast-mediated submerged fermentation utilizing Agro-industrial waste.

The challenges of pollution and agro-industrial waste management have led to the development of bioconversion techniques to transform these wastes into valuable products. This has increased the focus on the sustainable and cost-efficient production of biosurfactants from agro-industrial waste. Hence, the present study investigates the production of sophorolipid biosurfactants using the yeast strain IIPL32 under submerged fermentation, employing sugarcane bagasse hydrolysate-a renewable, low-cost agro-industrial waste as the feedstock.

SCN1A Genetic Alterations and Oxidative Stress in Idiopathic Generalized Epilepsy Patients: A Causative Analysis in Refractory Cases.

Single Nucleotide Polymorphisms (SNPs) have found it be associated with drug resistance in epilepsy. The purpose of this study was to determine the role of SCN1A gene polymorphism in developing drug resistance in idiopathic generalized epilepsy (IGE) patients, along with increased oxidative stress. The study was conducted at a tertiary care hospital in Delhi, India.

Incredible use of plant-derived bioactives as anticancer agents.

Cancer is a major global concern. Despite considerable advancements in cancer therapy and control, there are still large gaps and requirements for development. In recent years, various naturally occurring anticancer drugs have been derived from natural resources, such as alkaloids, glycosides, terpenes, terpenoids, flavones, and polyphenols.

The Impact of an Early Mobility Protocol on Recovery Outcomes in Patients Undergoing Abdominal Surgeries.

Background:  According to the World Health Organization (WHO), early mobilization is a critical component of healthcare that significantly impacts patient recovery and outcomes. Despite evidence supporting the benefits of early mobilization for abdominal surgery patients, standardized protocols remain scarce across many healthcare environments.

Aim:  This study evaluates the feasibility and impact of an early mobility protocol (EMP) on improvement in mobility and patient satisfaction in abdominal surgery patients.

Failed Spinal Anesthesia: Incidence and Associated Factors.

Introduction Spinal anesthesia, a commonly used technique for lower abdominal, pelvic, and lower extremity surgeries, involves injecting a local anesthetic into the subarachnoid space to temporarily block sensory, motor, and sympathetic nerves. Despite its high success rate, the failure of spinal anesthesia, which can lead to adverse patient outcomes, remains a concern. The failure rate varies widely, from 1% to 17%, influenced by factors such as technical challenges, patient anatomy, and practitioner experience.

YouTube Videos: A Learning Tool for Periodontology Education.

Introduction Video-based learning has proved to be an effective tool for education and knowledge gain in all fields. YouTube is a free video-sharing website consisting of numerous educational and skill development videos; you can even create and upload your videos to share knowledge and experience with others. YouTube contains videos about simple button sewing to space rocket preparation.

Bergenin, a bioactive flavonoid: advancements in the prospects of anticancer mechanism, pharmacokinetics and nanoformulations.

The natural world is a vast reservoir of exceptionally varied and inventive chemical compositions. Natural products are used as initial compounds to create combinatorial libraries by targeted modifications and then by analyzing their structure-activity connections. This stage is regarded as a crucial milestone in drug discovery and development.

BIMSSA: enhancing cancer prediction with salp swarm optimization and ensemble machine learning approaches.

Background: Cancer rates are rising rapidly, causing global mortality. According to the World Health Organization (WHO), 9.9 million people died from cancer in 2020.

International diet quality index and revised diet quality index relationship with type 2 diabetes disease: a case-control study.

Background: Type 2 diabetes mellitus (T2DM) is a global health crisis linked to increased cardiovascular risk. Research indicates that better dietary quality-higher intake of fruits, vegetables, and whole grains, and lower intake of processed foods-reduces T2DM risk. This study examines the relationship between T2DM and dietary quality indices (DQI-I and DQI-R) to determine if adherence can lower diabetes risk.

Structure-directing effect of terephthalate in bridging Zn(II)- and Cd(II)-based coordination polymers towards application in the detection of trace quantities of Pd in aqueous media and their electrical conductivities.

Energy crisis and environmental pollution are two central themes of contemporary research towards achieving sustainable development goals (SDGs). Material chemistry is the chief discipline that can resolve glitches in these areas through the appropriate design of chemical compounds with multifunctional properties. In this regard, two stable coordination polymers (CPs) were synthesised in this work using Zn(II) (3d) and Cd(II) (d) metal nodes with 1,4-benzenedicarboxylate () as the bridging ligand and monodentate pyridyl-N coordinated 9-fluoren-2-yl-pyridin-4-ylmethylene-amine (flpy) as the fluorogenic partner.