Integrative approach to decipher pharmacological mechanism of Cinnamomum zeylanicum essential oil in prostate cancer.

Prostate cancer has garnered much importance in recent years due to its rising incidence and mortality among men worldwide. The ineffectiveness of existing therapies and adverse events associated with conventional treatment have led patients to turn towards traditional medicine for the management of prostate cancer. Cinnamomum zeylanicum bark essential oil (CZEO) possesses promising anticancer properties, yet the exact mechanism of action of CZEO for the management of prostate cancer remains unclear.

The use of proximal fragment transverse Kirschner wire as a joystick to correct rotational displacement in Gartland type III pediatric supracondylar humerus fractures: a novel technique.

Supracondylar humerus fractures comprise of a major part in pediatric trauma cases. They result from a fall on an outstretched hand. The rotational components of Gartland type III fractures if not corrected appropriately can lead to cubitus varus (gun stock deformity).

Structural and supramolecular insights into crystalline multicomponent systems of 2,4-diamino-6-phenyl-1,3,5-triazine with various carboxylic acids.

Three multicomponent systems, namely, 2,4-diamino-6-phenyl-1,3,5-triazine-nicotinic acid (DAPT-NA), CHN·CHNO, (I), 2,4-diamino-6-phenyl-1,3,5-triazin-1-ium hydrogen malonate (DAPT-MMA), CHN·CHO, (II), and 2,4-diamino-6-phenyl-1,3,5-triazin-1-ium hydrogen (+)-dibenzoyl-D-tartarate (DAPT-DBTA), CHN·CHO, (III), have been synthesized and characterized via single-crystal X-ray diffraction, and their supramolecular interactions have been analysed. The formation of cocrystal (I) and salts (II) and (III) was confirmed through the widening of the C-N-C bond angle of the triazine moiety of 2,4-diamino-6-phenyl-1,3,5-triazine and the difference in the C-O bond distances between the carboxyl and carboxylate groups of the respective carboxylic acids. Cocrystal (I) and salt (II) form robust homomeric and heteromeric R(8) ring motifs through primary acid-base interactions and complementary base pairing.

New antibiotics targeting Gram-negative bacilli.

Antimicrobial resistance (AMR) is an emerging global threat. It increases mortality and morbidity rates and places a heavy burden on healthcare systems. Healthcare professionals can address the increasing issue of AMR by advocating responsible antibiotic use and supporting the development of new medications.

Health risk assessments of heavy metals in dust samples collected from classrooms in Ilorin, Nigeria and its impact on public health.

Over the past three decades, heavy metals (HMs) in indoor dust have been a significant focus due to their environmental and health risks. This study assessed HM contamination (Co, Pb, Cd, Cr, Ni, and As) in classroom and lecture theatre dust in Ilorin, Nigeria, across dry and rainy seasons. Dust samples from primary, secondary, and university settings were analyzed using atomic absorption spectrometry and ICP-OES.

Sinonasal and Laryngeal Presentations of Pituitary Adenoma.

Pituitary adenomas, the second most common intracranial pathology, often exhibit symptoms beyond the classic triad of headache, visual disturbances, and hormonal imbalances. Unusual presentations involve sinonasal pathology, cranial nerve involvement, and mass effects on adjacent structures like the skull base. Secretory adenomas may manifest hormonal changes and their effects.

"Golden Hour" in Road Traffic Accident Victims: Hurdles and Impact on Mortality.

Introduction Road traffic accident (RTA)-related death and disability are alarming health issues globally, which are rapidly increasing in developing countries. Timely presentation to a health center and prompt medical care are needed to prevent mortality and morbidity related to RTAs. This study was conducted to find out the hurdles in the golden hour arrival of RTA victims and to study its impact on RTA mortality at a tertiary health institute.

Enhancing energy efficiency in buildings using sawdust-based insulation in hot arid climates.

In the quest for sustainable construction solutions, this study explores the thermal insulation potential of sawdust as an eco-friendly material for building applications in hot-arid climates, with a focus on Iraq. The research evaluates the thermal behavior of sawdust when mixed with clay and glue, forming two different composite insulation materials. Laboratory experiments were conducted to measure thermal conductivity, with results compared against traditional insulators like Styrofoam.

Nuclei discovered new practical insights via optimized soliton-like pulse analysis in a space fractional-time beta-derivatives equations.

Nerve signal conduction, and particularly in myelinated nerve fibers, is a highly dynamic phenomenon that is affected by various biological and physical factors. The propagation of such moving electric signals may seemingly help elucidate the mechanisms underlying normal and abnormal functioning. This work aims to derive the exact physical wave solutions of the nonlinear partial differential equations with fractional beta-derivatives for the cases of transmission of nerve impulses in coupled nerves.

Artificial intelligence in stroke rehabilitation: From acute care to long-term recovery.

Stroke is a leading cause of disability worldwide, driving the need for advanced rehabilitation strategies. The integration of Artificial Intelligence (AI) into stroke rehabilitation presents significant advancements across the continuum of care, from acute diagnosis to long-term recovery. This review explores AI's role in stroke rehabilitation, highlighting its impact on early diagnosis, motor recovery, and cognitive rehabilitation.

Detection of concha bullosa using deep learning models in cone-beam computed tomography images: a feasibility study.

Background: Pneumatization of turbinates, also known as concha bullosa (CB), is associated with nasal septal deviation and sinonasal pathologies. This study aims to evaluate the performance of deep learning models in detecting CB in coronal cone-beam computed tomography (CBCT) images.

Methods: Standardized coronal images were obtained from 203 CBCT scans (83 with CB and 119 without CB) from the radiology archives of a dental teaching hospital.

DFT investigation of 5-fluorouracil tautomerism and non-covalent interactions with PLGA nanoparticles for enhanced drug delivery and sensing.

This study investigates the non-covalent interactions between both the free and tautomeric forms of 5-fluorouracil (5-FU) and poly(lactic-co-glycolic acid) (PLGA) nanoparticles through density functional dispersion correction (DFT-D) at the B3LYP-D level in a dichloromethane (DCM) and water environments. Our results indicate that the non-covalent interactions formed between the carbonyl and amide groups of the free form of 5-FU and the carboxyl group of PLGA facilitate a rapid initial release of the drug, aligning with experimental findings. The calculated binding energies for 5-FU in its keto-enol (-0.

Phytochemical profiling, molecular docking and ADMET prediction of alkaloid rich fraction of blume seeds against Alzheimer's disease.

The limitations of current Alzheimer's disease (AD) therapies necessitate novel treatment approaches. Blume, a plant traditionally used in India for neurological disorders, was investigated for its therapeutic potential in AD. alkaloid-rich fraction (EAF) was analysed using LCMS and GCMS, identifying 66 phytochemicals.

Unlocking the potential of THR-β agonist therapies: resmetirom's chemistry, biology, and patent insights.

Non-alcoholic steatohepatitis (NASH) is a severe manifestation of non-alcoholic fatty liver disease (NAFLD), which is characterized by hepatic steatosis, inflammation, and hepatocyte destruction. Newly adopted nomenclature, metabolic dysfunction-associated fatty liver disease (MAFLD), allows to signify the importance of metabolic dysfunction. For which the current treatment options are limited and often associated with adverse effects, creating a need for targeted therapies.

Periodontal pathogens as potential risk factors for systemic diseases: An overview.

There is a plethora of evidence that suggests infection may either directly or indirectly trigger chronic inflammatory processes which may then act as a risk factor for diabetes mellitus and atherosclerosis. Inflammatory periodontal disease like periodontitis, is among the most prevalent oral infectious disease. It affects the tissues that support the teeth and has reportedly been linked to systemic conditions like diabetes mellitus and atherosclerosis.

Urease-coupled systems and materials: design strategies, scope and applications.

Synthetic systems have co-opted urease, a crucial enzyme serving many biological functions, to recapitulate complex biological features. Therefore, the urease-urea feedback reaction network (FCRN) is reciprocated with soft materials to induce various animate-like features, including self-regulation, error correction, and decision-making capabilities, that are processed through a variety of non-linear functions. Although free-urease-based homogeneous systems are capable of adhering to many non-linear characteristics, they lack the ability to showcase the diffusion-controlled spatiotemporal phenomena.

Addressing the global challenge of bacterial drug resistance: insights, strategies, and future directions.

The COVID-19 pandemic underscored bacterial resistance as a critical global health issue, exacerbated by the increased use of antibiotics during the crisis. Notwithstanding the pandemic's prevalence, initiatives to address bacterial medication resistance have been inadequate. Although an overall drop in worldwide antibiotic consumption, total usage remains substantial, requiring rigorous regulatory measures and preventive activities to mitigate the emergence of resistance.

A Comprehensive Guide to Implement Artificial Intelligence Cloud Solutions in a Dental Clinic: A Review.

Integrating the artificial intelligence (AI) cloud into dental clinics can enhance diagnostics, streamline operations, and improve patient care. This article explores the adoption of AI-powered cloud solutions in dental clinics, focusing on infrastructure requirements, software licensing, staff training, system optimization, and the challenges faced during implementation. It provides a detailed guide for dental practices to transition to AI cloud systems.

An Investigation Into the Hepatoprotective Properties of Berberis asiatica, Withania somnifera, and Their Combination in Streptozotocin-Nicotinamide-Induced Type II Diabetes Mellitus in Wistar Rats.

Background:  The rising prevalence of type II diabetes mellitus (T2DM) has increased the risk of hepatic dysfunction, necessitating effective therapeutic interventions. Natural products, particularly (BA) and (WS), are known for their hepatoprotective properties.

Objectives: This study investigates the hepatoprotective effects of BA, WS, and their polyherbal combination in streptozotocin-nicotinamide-induced T2DM in Wistar rats.