Efficacy of Early Goal-Directed Therapy in Septic Shock Management: A Systematic Review.

Septic shock is a serious and life-threatening illness marked by potentially fatal and metabolic abnormalities, leading to high mortality rates in adult patients. Early goal-directed therapy (EGDT) was introduced as a systematic approach to manage septic shock through early, protocol-based hemodynamic optimization to improve outcomes. This systematic review aims to evaluate the efficacy of EGDT in managing adult patients with septic shock.

Cross-sectional study exploring the prevalence and clinical manifestations of acute diarrhea among under-5 children in primary care hospital in Democratic Republic of the Congo.

Background: Acute diarrhea (AD), which is defined as frequent passing of liquid stools compared to normal, is a serious and worrying problem and remains a concern for healthcare systems because of its high mortality cause in children under 5 years old. The authors' study aimed to present the prevalence and to describe the clinical manifestation of AD among under-5 children.

Methods: From June 2022 to May 2023, the authors conducted a retrospective, descriptive and cross-sectional study including all patients aged 0-5 years hospitalized for AD.

Hemorrhagic hepatic infarction in a pregnant woman with severe pre-eclampsia: a case report.

Introduction And Importance: Severe pre-eclampsia is a medical condition that affects women during the last two trimesters of pregnancy. Hemorrhagic hepatic infarction is a hepatic complication and is rarely encountered in women with severe pre-eclampsia. This case report aims to present the characteristics of hemorrhagic hepatic infarction in a pregnant woman with severe pre-eclampsia.

Immune Thrombocytopenic Purpura (ITP) With Ulcerative Colitis (UC).

Inflammatory bowel disease (IBD) includes ulcerative colitis (UC) and Crohn's disease. A relapsing, immune-modulated illness, it causes inflammation of the small and large intestines.  UC is sometimes associated with extra-intestinal manifestations, including autoimmune cytopenias.

Role of advanced imaging in primary hepatic neuroendocrine tumor with borderline raised AFP and negative chromogranin staining: A case report.

Background: Primary hepatic neuroendocrine tumors (PHNETs) are rare, accounting for approximately 0.3 % of all neuroendocrine tumors (NETs) and are often difficult to diagnose due to their nonspecific symptoms and imaging features. Standard diagnostic and treatment protocols are lacking due to their rarity, but imaging and immunohistochemistry (IHC) remain key tools for diagnosis.

Long-Term Impacts of COVID-19 on Thyroid Health: Insights From Clinical Studies.

Background: COVID-19 emerged in December 2019 and rapidly became a global pandemic. It has since been associated with the progression of various endocrine disorders, including thyroid disease. The long-term effects of this interplay have yet to be explored.

Planetary Health Booms: Unpacking the Surge in Research Across the Globe Through Joint-Point Analysis.

Planetary Health (PH) is a relatively new field that studies the sciences behind the interaction between the environment, living organisms, and human health. The number of publications in this field has increased exponentially in the past few years. This study analyzed the trend of using the term "PH" in literature.

Management of recurrent end-stage achalasia with robotic-assisted esophagectomy: a case report and literature review.

Introduction And Importance: Achalasia, an uncommon esophageal motility disorder, presents therapeutic challenges, especially in refractory cases with a history of multiple surgeries. Here, we present a complex case illustrating the dilemmas and multidisciplinary approach required in managing such patients. This case underscores the relevance of newer techniques like robotic-assisted esophagectomy in refractory achalasia management.

Effect of vitamin D supplementation on cardiovascular outcomes: an updated meta-analysis of RCTs.

Objective: To evaluate the effect of vitamin D supplementation on cardiovascular outcomes.

Methods: After searching different databases, we retrieved and included randomized controlled trials on long-term supplementation of vitamin D (≥1-year intervention) and reporting cardiovascular outcomes. We calculated risk ratio (RR) with 95% confidence intervals (CI) for dichotomous outcomes.

Granulomatosis With Polyangiitis Mimicking Infective Endocarditis: A Case Report.

Granulomatosis with polyangiitis is a rare systemic disease that causes necrotizing granulomatous inflammation of small- and medium-sized blood vessels. We present the case of a 46-year-old male with medical history significant for chronic sinusitis, prior history of drug abuse, and a recent tooth infection. He was suspected to have infective endocarditis, but further workup revealed diagnostic findings of granulomatosis with polyangiitis.

Cardiovascular Imaging in the Era of Precision Medicine: Insights from Advanced Technologies - A Narrative Review.

Background And Aims: Cardiovascular diseases are responsible for a high mortality rate globally. Precision medicine has emerged as an essential tool for improving cardiovascular disease outcomes. In this context, using advanced imaging exams is fundamental in cardiovascular precision medicine, enabling more accurate diagnoses and customized treatments.

Aptitude for Research Among Medical Students in India: Identifying the Challenges.

Introduction Understanding the reasons behind the undervaluation of research among undergraduate medical students in India is crucial for advancing medical knowledge. This cross-sectional study aims to investigate the knowledge, interest, and barriers faced by 606 Indian medical students through an online questionnaire distributed via social media platforms. Aims To identify the knowledge of research and the challenges faced by medical students to pursue research in their undergraduate education.

Exploring the clinical effectiveness of glucagon-like peptide-1 receptor agonists in managing cardiovascular complications: an updated comprehensive review and future directives.

The possible cardiovascular advantages of glucagon-like peptide-1 receptor agonists (GLP-1RAs), a class of drugs predominantly used to treat type 2 diabetes (T2D), have garnered increasing attention in recent years. Clinical trials have looked into the possibility that GLP-1RAs have extra cardioprotective benefits in addition to their ability to manage T2D, demonstrating significant major adverse cardiovascular events (MACE) reduction and a favorable safety profile. GLP-1 RAs improve cardiovascular outcomes, especially in those with existing cardiovascular disease.

Temporal Trends in Racial and Gender Disparities of Early Onset Colorectal Cancer in the United States: An Analysis of the CDC WONDER Database.

Background: The mortality rates of early-onset colorectal cancer (EOCRC) have surged globally over the past two decades. While the underlying reasons remain largely unknown, understanding its epidemiology is crucial to address this escalating trend. This study aimed to identify disparities potentially influencing these rates, enhancing risk assessment tools, and highlighting areas necessitating further research.

Molecular basis of sepsis: A New insight into the role of mitochondrial DNA as a damage-associated molecular pattern.

Sepsis remains a critical challenge in the field of medicine, claiming countless lives each year. Despite significant advances in medical science, the molecular mechanisms underlying sepsis pathogenesis remain elusive. Understanding molecular sequelae is gaining deeper insights into the roles played by various damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) in disease pathogenesis.

Smoking is a predominant risk factor for coronary artery disease among Indians.

Smoking has emerged as a predominant risk factor for coronary artery disease (CAD) in India, contributing significantly to the country's rising cardiovascular morbidity and mortality rates. The adverse effects of tobacco on cardiovascular health are well-documented, exacerbating a public health challenge in a nation with a high prevalence of smoking. Therefore, it is of interest to analyse the impact of smoking on the incidence and progression of coronary artery disease among the Indian population, emphasizing the need for targeted public health interventions to mitigate this risk factor.

Effect of Pemafibrate on the Lipid Profile, Liver Function, and Liver Fibrosis Among Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease.

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) are prevalent conditions linked to obesity and metabolic disturbances, with potential complications such as cirrhosis and cardiovascular risks. This systematic review and meta-analysis aimed to evaluate the efficacy of pemafibrate, a drug targeting fat and sugar metabolism genes, in treating patients with MASLD/MASH.

Methods: Databases such as MEDLINE, Web of Science, Cochrane Library, and Scopus were searched until September 2023 to identify relevant studies.

Factors Contributing to the Development of Neuropsychiatric Manifestations in Persons With Multiple Sclerosis: A Systematic Review.

Multiple sclerosis (MS) is the most common chronic demyelinating disease affecting the central nervous system (CNS) and is distinguished by neuroinflammation and neurodegeneration. It has four categories based on clinical course, with relapsing-remitting being the most common type. MS predominantly manifests with motor and sensory dysfunctions.

Optical coherence tomography catheter-induced vasospasm of the left anterior descending artery: A case report.

Optical coherence tomography (OCT) helps identify coronary artery disease of different etiologies. Vasospasm from OCT catheter is a rarely reported complication that is more commonly seen in the right coronary artery. We report a case of OCT-catheter induced vasospasm of the left anterior descending artery that resolved with administration of nitroglycerine.