5 results match your criteria: "DeBusk College of Osteopathic Medicine at Lincoln Memorial University-Knoxville[Affiliation]"
Implications of microgravity-induced cell signaling alterations upon cancer cell growth, invasiveness, metastatic potential, and control by host immunity.
Int Rev Cell Mol Biol
February 2022
Department of Basic Medical Sciences, DeBusk College of Osteopathic Medicine at Lincoln Memorial University-Knoxville, Knoxville, TN, United States. Electronic address:
The human endeavor to venture beyond the orbit of Earth is challenged by both continuous space radiation and microgravity-induced immune dysfunction. If cancers were to develop in astronauts, it is unclear how these abnormal cells would grow and progress in the microgravity environment. It is unknown if the astronaut's immune response would be able to control or eradicate cancer.
View Article and Find Full Text PDFModel Systems for the Study of Malignant Melanoma.
Methods Mol Biol
April 2021
Department of Basic Medical Sciences, DeBusk College of Osteopathic Medicine at Lincoln Memorial University-Knoxville, Knoxville, TN, USA.
Since the first resection of melanoma by Hunter in 1787, efforts to treat patients with this deadly malignancy have been ongoing. Initial work to understand melanoma biology for therapeutics development began with the employment of isolated cancer cells grown in cell cultures. However, these models lack in vivo interactions with the tumor microenvironment.
View Article and Find Full Text PDFTime Course of Recovery for Performance Attributes and Circulating Markers of Muscle Damage Following a Rugby Union Match in Amateur Athletes.
Sports (Basel)
May 2020
Exercise Science, Health and Human Performance Research Group, Department of Sport Sciences, Institute of Health Sciences, Federal University of Triangulo Mineiro, Uberaba 38025-350, Brazil.
Article Synopsis
- A study of 14 amateur rugby players assessed the effects of a single match on muscle performance and damage over a period of up to 96 hours.
- Immediate increases in muscle damage markers (CK and LDH) were observed right after the match and persisted for 24 hours.
- Performance measures, particularly change of direction, showed significant impairment that lasted longer than speed-related activities, revealing varying recovery times for different aspects of neuromuscular performance.
Simulated microgravity-mediated reversion of murine lymphoma immune evasion.
Sci Rep
October 2019
Magnolia Research Center, Division of Biomedical Sciences, Department of Microbiology and Immunology, Edward Via College of Osteopathic Medicine Carolinas Campus, Spartanburg, SC, 29303, USA.
No human has returned to the moon since the end of the Apollo program 47 years ago, however, new missions are planned for an orbital outpost. Space radiation and the potential for cancer remain as important issues to the future of human space exploration. While improved shield technologies and protective biologicals are under development, little is known concerning the interaction between cancer cells and host immunity in microgravity.
View Article and Find Full Text PDFProlonged exposure to simulated microgravity diminishes dendritic cell immunogenicity.
Sci Rep
September 2019
Magnolia Research Center, Division of Biomedical Sciences, Department of Microbiology and Immunology, Edward Via College of Osteopathic Medicine Carolinas Campus, Spartanburg, SC, 29303, USA.
Immune dysfunction due to microgravity remains a hurdle in the next step of human space exploration. Dendritic cells (DC) represent a critical component of immunity, given their role in the detection of invaders and the subsequent task of activating T cells to respond and eliminate the threat. Upon encounter with microbes, DC undergo a process of maturation, whereby the cells upregulate the expression of surface proteins and secrete cytokines, both required for the optimal activation of CD4 and CD8 T cells.
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