Integration of Sustainable and Net-Zero Concepts in Shape-Memory Polymer Composites to Enhance Environmental Performance.

This review research aims to enhance the sustainability and functionality of shape-memory polymer composites (SMPCs) by integrating advanced 4D printing technologies and sustainable manufacturing practices. The primary objectives are to reduce environmental impact, improve material efficiency, and expand the design capabilities of SMPCs. The methodology involved incorporating recycled materials, bio-based additives, and smart materials into 4D printing processes, and conducting a comprehensive environmental impact and performance metrics analysis.

Exploring the effects of multiple online interaction on emotions of L2 learners in synchronous online classes.

The decline in both the quantity and quality of interaction has emerged as a notable challenge in online learning. However, the definition of interaction quality remains unclear. This study clarifies it as a decrease in the breadth of interaction, which refers to interaction that can only cover a smaller number of learners.

SNARC-like effect for tempo is consistent for fast and full tempo ranges but still controversial for slow tempo range.

Recent evidence suggested the existence of a spatial associations for music tempo with faster left-hand responses to relatively slow tempos and faster right-hand responses to relatively fast tempos. We refer to a study that systematically explored these spatial associations across different tempo ranges, revealed a clear effect only in the fast tempo range (DOI 10.3758/s13414-019-01945-8).

Help-seeking and access to care for stroke and heart attack during the COVID-19 pandemic: A qualitative study.

In this article we explore how people who experienced a stroke, transient ischaemic attack, or heart attack sought health care during the COVID-19 lockdown periods. Semi-structured interviews were conducted with 27 patients admitted to hospital between March 2020 and May 2021, and one carer who was recruited from cardiac and stroke rehabilitation services in two large acute NHS trusts in England. Drawing on concepts of candidacy, illness and moral work, we discuss how people's sense-making about their symptoms fundamentally shaped both their decisions about seeking help and the impact of COVID-19 on help seeking.

Suspected poor-quality medicines in Kenya: a retrospective descriptive study of medicine quality-related complaints reports in Kenya's pharmacovigilance database.

Poor-quality, substandard and falsified, medicines pose a significant public health threat, particularly in low-middle-income countries. A retrospective study was performed on Kenya's Pharmacovigilance Electronic Reporting System (2014-2021) to characterize medicine quality-related complaints and identify associations using disproportionality analysis. A total of 2767 individual case safety reports were identified, categorized into medicines with quality defects (52.

Cyanocobalamin-loaded dissolving microneedles diminish skin inflammation in vivo.

Inflammatory diseases of the skin have a considerable high prevalence worldwide and negatively impact the patients' quality of life. First-line standard therapies for these conditions inherently entail important side effects when used long-term, particularly complicating the management of chronic cases. Therefore, there is a need to develop novel therapeutic strategies to offer reliable alternative treatments.

Exploring dental anxiety as a mediator in the relationship between mindfulness or self-compassion and dental neglect.

Dental anxiety and dental neglect are interconnected constructs with profound consequences for oral health and corresponding challenges for dental professionals. Meanwhile, other literature has indicated that mindfulness and self-compassion relate negatively to different forms of anxiety, and propose elements of potential interventions. This study aimed to explore the potential impact of dental anxiety as a mediator on the relationships between mindfulness or self-compassion and dental neglect.

Switchable PAMAM megamers for deep tumor penetration and enhanced cell uptake.

Nanoparticles fabricated to deliver anticancer drugs are usually designed to present optimized tumor penetration and cell internalization. However, there are some barriers and difficulties with most current technologies. Herein, size and charge switchable polyamidoamine (PAMAM) megamers (SChPMs) were prepared for the delivery of doxorubicin (DOX).

Catalysing Environmental Action: a Governance Framework for Enhancing Individual Participation in Sub-Saharan Africa's Plastic Circular Economy.

Plastic waste poses a significant challenge to achieving sustainable production and consumption of resources, particularly in sub-Saharan Africa where effective governance and waste management systems are lacking. In this paper, we develop an empirical understanding of the influence of public governance system on promoting circular economy (CE) for plastic actions among individuals. Through a survey of 1475 participants across five sub-Saharan African countries, we tested five hypotheses drawing on New Governance Theory and CE Action Recipe to explore the relationship between governance and individual's actions supporting CE for plastic.

Mouse cursor trajectories capture the flexible adaptivity of predictive sentence processing.

Recent psycholinguistic findings raise fundamental questions about comprehenders' ability to rationally adapt their predictions during sentence processing. Two mouse cursor tracking experiments (each = 85) assessed this adaptivity by manipulating the reliability of verb-based semantic cues. In Experiment 1, predictive mouse cursor movements to targets (e.

Integrating restoration and interactive exploration to enhance cultural heritage through VR storytelling.

Redtory was transformed from an old industrial site into a creative park in Guangzhou. Unfortunately, it was demolished in May 2019. It holds a dual significance, representing both Guangzhou's old industrial era and its first creative park (Art and Design).

Nursing staff's attitudes towards the prevention of adverse events among hospitalized people with dementia: Protocol of qualitative systematic review and evidence synthesis.

Introduction: People with dementia are more likely than people without dementia to be hospitalized and to experience in-hospital preventable adverse events, such as falls, skin injury, and infection, compared to other hospitalized groups. Negative attitudes towards people with dementia are common among acute healthcare workers and have been linked to a cascade of negative adverse events in this population. However, no qualitative systematic review has ever been conducted to synthesize the existing evidence in this area, which hampers the development of preventative measures.

A retrospective propensity-score-matched cohort study of the impact of procalcitonin testing on antibiotic use in hospitalized patients during the first wave of COVID-19.

Background: Procalcitonin (PCT) is a blood marker used to help diagnose bacterial infections and guide antibiotic treatment. PCT testing was widely used/adopted during the COVID-19 pandemic in the UK.

Objectives: Primary: to measure the difference in length of early (during first 7 days) antibiotic prescribing between patients with COVID-19 who did/did not have baseline PCT testing during the first wave of the pandemic.

Ocular pharmacokinetics of acetazolamide from intravitreal implants by high-performance liquid chromatography coupled to tandem mass spectrometry.

Glaucoma, a leading cause of irreversible blindness, affects about 70 million people globally. Its treatment focuses on reducing intraocular pressure. Acetazolamide, a potent anti-glaucoma drug, is currently used only systemically due to low solubility and permeation, which cause severe side effects.

Morchella conica, Morchella esculenta and Morchella delicosa Induce Apoptosis in Breast and Colon Cancer Cell Lines via Pro-apoptotic and Anti-apoptotic Regulation.

Objective: To explore the potential apoptotic mechanisms of 3 Morchella extracts (Morchella conica, Morchella esculenta and Morchella delicosa) on breast and colon cancer cell lines using apoptotic biomarkers.

Methods: Human breast cell line (MCF-7) and colon cancer cell line (SW-480) were treated with methanol and ethanol extracts of 3 Morchella species with concentration ranging from 0.0625 to 2 mg/mL.

Novel biopolymer spray formulation for drug delivery in precision dentistry.

Addressing the growing challenges of periodontal and peri-implant diseases, this study first reports a promising advancement in precision dentistry: an intricately formulated biopolymer spray designed for precise, localized drug delivery during tailored dental procedures. Poly (lactic--glycolic acid) (PLGA), recognized for its controlled release, biodegradability, and FDA-approved biocompatibility, forms the core of this formulation. Utilizing the double emulsion method, PLGA microparticles (PLGA-MPs) were loaded with dental antibiotics: sodium amoxicillin (AMX-Na), trihydrate amoxicillin (AMX-Tri), and metronidazole (Met).

The emergence and use of expanded carrier screening in gamete donation: A new form of repro-genetic selection.

With the continued expansion and commercialisation of fertility treatments, the selection and matching of donors have become more sophisticated and technologised. As part of this landscape, new form of genetic screening: 'expanded carrier screening' (ECS) is being offered as a technique to avoid the risk of donors passing on genetic conditions to future offspring. Allowing donors to be tested for hundreds of genetic conditions simultaneously, ECS marks a considerable departure from traditional 'family history' models of screening, which rely on an individual's knowledge of family health.

EFNet: A multitask deep learning network for simultaneous quantification of left ventricle structure and function.

Purpose: The purpose of this study is to develop an automated method using deep learning for the reliable and precise quantification of left ventricle structure and function from echocardiogram videos, eliminating the need to identify end-systolic and end-diastolic frames. This addresses the variability and potential inaccuracies associated with manual quantification, aiming to improve the diagnosis and management of cardiovascular conditions.

Methods: A single, fully automated multitask network, the EchoFused Network (EFNet) is introduced that simultaneously addresses both left ventricle segmentation and ejection fraction estimation tasks through cross-module fusion.

IoT Forensics: Current Perspectives and Future Directions.

The Internet of Things forensics is a specialised field within digital forensics that focuses on the identification of security incidents, as well as the collection and analysis of evidence with the aim of preventing future attacks on IoT networks. IoT forensics differs from other digital forensic fields due to the unique characteristics of IoT devices, such as limited processing power and connectivity. Although numerous studies are available on IoT forensics, the field is rapidly evolving, and comprehensive surveys are needed to keep up with new developments, emerging threats, and evolving best practices.

AI-Driven Data Analysis of Quantifying Environmental Impact and Efficiency of Shape Memory Polymers.

This research investigates the environmental sustainability and biomedical applications of shape memory polymers (SMPs), focusing on their integration into 4D printing technologies. The objectives include comparing the carbon footprint, embodied energy, and water consumption of SMPs with traditional materials such as metals and conventional polymers and evaluating their potential in medical implants, drug delivery systems, and tissue engineering. The methodology involves a comprehensive literature review and AI-driven data analysis to provide robust, scalable insights into the environmental and functional performance of SMPs.

A study of TiO-enhanced nanofluids in internal combustion engines using neural networks.

In this study, the effects of nanoparticle addition to internal combustion engines were investigated. Firstly, engine coolant was prepared by mixing nanoparticles with water in different ratios (0%, 0.15%, 0.

Enhancing linezolid activity in the treatment of oral biofilms using novel chitosan microneedles with iontophoretic control.

This study aimed to prepare and assess active microneedle (MN) patches based on a novel biomaterial and their effective coupled (physical and electrical) transdermal delivery of a model drug (Linezoid). Modified MN patches (e.g.

Physicochemical properties, biological chemistry and mechanisms of action of caries-arresting diammine-silver(I) fluoride and silver(I)-fluoride solutions for clinical use: a critical review.

This paper serves as a Part II follow-up of our research investigations performed on the molecular structures of silver(I)-fluoride (SF) and diammine-silver(I) fluoride (SDF) complexes in solution-based commercial products for clinical application, their precise chemical compositions, and their nature in aqueous solution, the latter including rapid fluoride-exchange processes at the silver(I) ion centre monitored by F NMR analysis (Part I). Part I of this series also explores the mechanisms of action (MoA) of these complexes, and is therefore largely focused on their chemical reactions with constituents of human saliva, which has access to their sites of application. Such reactions were found to slowly promote the generation of potentially physiologically-active Ag/AgCl nanoparticles from primarily-generated discoloured silver(I) chloride (AgCl) precipitates, a process involving salivary electron-donors such as thiocyanate and L-cysteine.

Enhancing supply chain relationships in the circular economy: Strategies for a green centralized supply chain with deteriorating products.

This article introduces a green centralized supply chain in a two-stage stochastic programming model using deteriorating products. The model reduces the cost of purchasing, transporting, storing, product recovery and shortages. This cuts down on greenhouse emission related to transportation, product recovery, and recycling programs.