Photokinetics of Photothermal Reactions.

Photothermal reactions, involving both photochemical and thermal reaction steps, are the most abundant sequences in photochemistry. The derivation of their rate laws is standardized, but the integration of these rate laws has not yet been achieved. Indeed, the field still lacks integrated rate laws for the description of these reactions' behavior and/or identification of their reaction order.

Persuasiveness of Public Health Communication During the COVID-19 Pandemic: Message Framing, Threat Appraisal, and Source Credibility Effects.

This study examines the relative effectiveness of the UK government's public health messages used during the first wave of the COVID-19 pandemic. We focus on the use of a loss versus gain frame. We look at the effect of framing on behavioural inclination to follow COVID-19 guidance, as well as affective mechanisms and individual characteristic moderators that might explain said willingness.

Speciation of Potentially Carcinogenic Trace Nickel(II) Ion Levels in Human Saliva: A Sequential Metabolomics-Facilitated High-Field H NMR Investigation.

Since the biological activities and toxicities of 'foreign' and/or excess levels of metal ions are predominantly determined by their precise molecular nature, here we have employed high-resolution H NMR analysis to explore the 'speciation' of paramagnetic Ni(II) ions in human saliva, a potentially rich source of biomolecular Ni(II)-complexants/chelators. These studies are of relevance to the corrosion of nickel-containing metal alloy dental prostheses (NiC-MADPs) in addition to the dietary or adverse toxicological intake of Ni(II) ions by humans. Unstimulated whole-mouth human saliva samples were obtained from n = 12 pre-fasted (≥8 h) healthy participants, and clear whole-mouth salivary supernatants (WMSSs) were obtained from these via centrifugation.

Where is the voice of lived experience in interprofessional education? A scoping review.

The main goal of interprofessional education (IPE) is to improve services and the quality of care for patients, their families, and communities. Enabling different professional learners, or others with relevant care roles, to learn together, is expected to advance care delivery. For both pre and post-registration learning, it therefore follows that listening to and working with service users is essential to underpin interprofessional learning.

EXPRESS: Sleep supports the consolidation of newly learned statistical concepts.

Within mathematical cognition the development of conceptual knowledge is seen as critical to developing understanding. Sleep has been well established to play a role in the consolidation of newly learned information and schema-based information but has yet to be explored within mathematical cognition. Across three experiments participants (N = 167) were assigned to a sleep or wake group and then viewed lectures on either p-values, t-test, or z-scores.

Retrieving and Identifying Remnants of Artefacts on Local Devices Using Sync.com Cloud.

Most current research in cloud forensics is focused on tackling the challenges encountered by forensic investigators in identifying and recovering artifacts from cloud devices. These challenges arise from the diverse array of cloud service providers as each has its distinct rules, guidelines, and requirements. This research proposes an investigation technique for identifying and locating data remnants in two main stages: artefact collection and evidence identification.

Unraveling the Atomistic Mechanism of Electrostatic Lateral Association of Peptide β-Sheet Structures and Its Role in Nanofiber Growth and Hydrogelation.

Guiding molecular assembly of peptides into rationally engineered nanostructures remains a major hurdle against the development of functional peptide-based nanomaterials. Various non-covalent interactions come into play to drive the formation and stabilization of these assemblies, of which electrostatic interactions are key. Here, the atomistic mechanisms by which electrostatic interactions contribute toward controlling self-assembly and lateral association of ultrashort β-sheet forming peptides are deciphered.

Experimental and Mathematical Modelling Investigation of Plasma Electrolytic Oxidation (PEO) for Surface Hardening of 20Ch Steel.

This study aimed to develop an alternative surface hardening technique for low-carbon steel alloy type 20Ch using plasma electrolytic oxidation (PEO). The surface hardening of 20Ch alloy steel samples was achieved through PEO in a NaCO electrolyte solution. Optimal processing parameters were determined experimentally by measuring voltage and applied current.

The Use of the Parents' Evaluation of Developmental Status and Developmental Milestones in Screening Children for Developmental Delay in India.

Background/objectives: The Parents' Evaluation of Developmental Status (PEDS) and Developmental Milestones (PEDS:DM) are cost-effective, self-report tools that can be conveniently utilized in low- and middle-income countries to screen for developmental delays in children. This study assessed the diagnostic accuracy of PEDS and PEDS:DM in distinguishing children with typical development (TD) from those with developmental disabilities (DD). It also examined the relationship between parents' general concerns and specific developmental concerns about their children.

Perception of the Importance of Inherited Genetics and Lifestyle on the Development of Chronic Diseases: A UK Cross-Sectional Survey.

Background And Aims: There is emerging evidence that genes, lifestyles and environment play a prominent role in the development of non-communicable diseases. Currently, there is not information on people's perception of inherited genetics vs. lifestyle on disease development.

Spatiotemporal multi-feature fusion vehicle trajectory anomaly detection for intelligent transportation: An improved method combining autoencoders and dynamic Bayesian networks.

With the continuous development of intelligent transportation systems, traffic safety has become a major societal concern, and vehicle trajectory anomaly detection technology has emerged as a crucial method to ensure safety. However, current technologies face significant challenges in handling spatiotemporal data and multi-feature fusion, including difficulties in big data processing, and have room for improvement in these areas. To address these issues, this paper proposes a novel method that combines autoencoders, Mahalanobis distance, and dynamic Bayesian networks for anomaly detection.

Quality-by-design principles applied to the development and optimisation of lidocaine-loaded dissolving microneedle arrays - a proof-of-concept.

The use of dissolving microneedle arrays (dMNA) for intradermal and transdermal drug delivery has been a growing trend in the field for the past decades. However, a lack of specific regulatory standards still hinders their clinical development and translation to market. It is also well-known that dMNA composition significantly impacts their performance, with each new formulation potentially presenting a challenge for developers, manufacturers and regulatory agencies.

Health care assistant and registered nurse dyads, working together and apart - a qualitative study.

Background: This study was undertaken to understand the role of the Health Care Assistants and how they negotiate roles and responsibilities with Registered Nurses in adult acute hospitals.

Methods: The qualitative approach of focused ethnography used non-participant observation and interviews with staff from four acute wards. Field notes and interview data, analysed using NVIVO10, moved data from description through explanation, interpretation and identification of themes.

How do patients determine when their inhaler is empty? Insights from an analysis of returned inhalers and a patient survey.

Background: Inhalers are widely used for the management of asthma and chronic obstructive pulmonary disease. However, there is little knowledge about the extent to which an inhaler is used and when it is disposed of, despite the implications for an individual's health (when used beyond the recommended number of doses (overused)), and medicine wastage, healthcare costs and the environment (when discarded with remaining doses (underused)). To explore inhaler use, we assessed the number of doses remaining in pressurised metered-dose inhalers (pMDIs) returned via a Chiesi Inhaler Recycling scheme.

Synergistic effects of doxorubicin loaded silk fibroin nanoparticles and Cu-TiO nanoparticles for local chemo-sonodynamic therapy against breast cancer.

A promising new approach to mitigate the adverse effects of chemotherapeutic drugs on healthy tissues involves combining sonodynamic therapy with topical chemotherapy to enhance the therapeutic efficacy of anticancer drugs. In this study, we introduce a multi-functional in situ chitosan hydrogel (CS) containing silk fibroin nanoparticles (SFNPs) loaded with doxorubicin (DOXSFNPs) and CuO/TiO nanoparticles (CTNPs) for combination therapy. The developed DOXSFNPs exhibited a size of 257 ± 6 nm, a zeta potential of -14.

Optimizing extrusion processes and understanding conformational changes in itraconazole amorphous solid dispersions using in-line UV-Vis spectroscopy and QbD principles.

This paper presents a comprehensive investigation of the manufacturing of itraconazole (ITZ) amorphous solid dispersions (ASDs) with Kolllidon® VA64 (KVA64) using hot-melt extrusion (HME) and in-line process monitoring, employing a Quality by Design (QbD) approach. A sequential Design of Experiments (DoE) strategy was utilized to optimize the manufacturing process, with in-line UV-Vis spectroscopy providing real-time monitoring. The first DoE used a fractional factorial screening design to evaluate critical process parameters (CPPs), revealing that ITZ concentration had the most significant impact on the product quality attributes.

"Navigating Risk and Responsibility?": A Mixed-Methods Study Addressing Stigma and Well-Being Among Men Who Have 'Sex on Chems' with Other Men in the English Midlands.

Background: Most research on 'Chemsex' has been conducted with gay, bi-sexual, and men who have sex with men (GBMSM) in large cities with well-established infrastructures. Therefore, this study aimed to explore the 'Chemsex' risks and responsibilities of GBMSM who lived outside of the queer metropolis. This study also aimed to understand how stigma and mental health present in the absence of a well-established community infrastructure.

Albumin Is an Integrative Protein of Blood Plasma and Beyond.

Albumin is a major protein in mammalian blood plasma or serum, where its concentration in healthy organisms is about 600 μM [...

Antiangiogenic Potential of Pomegranate Extracts.

Pomegranate ( L.) has long been recognised for its rich antioxidant profile and potential health benefits. Recent research has expanded its therapeutic potential to include antiangiogenic properties, which are crucial for inhibiting the growth of tumours and other pathological conditions involving aberrant blood vessel formation.

Recent progress in topical and transdermal approaches for melanoma treatment.

The global incidence of melanoma, the most lethal form of skin cancer, continues to escalate, emphasizing the urgent need for more effective therapeutic strategies. This review assesses the latest advancements in topical and transdermal drug delivery systems, positioning them as promising alternatives. These systems allow for the direct application of therapeutic agents to tumor sites, enhancing drug effectiveness, improving patient compliance, and reducing systemic toxicity.

Symptomatic associations and sexual differences in depression and communication.

Previous studies have explored the associations between parental and offspring's depression and parent-child communication. However, few studies have investigated their symptomatic associations and potential sex differences. Therefore, this study aims to examine their associations and sex differences in parents and offspring.

AI-driven predictive models for sustainability.

This research presents an AI-driven, explainable energy management model that aligns with Net Zero sustainability objectives by optimizing energy consumption, enhancing predictive accuracy, and ensuring transparency. The model integrates machine learning algorithms, like Gradient Boosting Machines (GBM) and Random Forests, and utilizes techniques like SHAP and LIME for interpretability. Data was split 70/30 for training and validation, with 10-times validation to avoid overfitting, achieving a Mean Absolute Error (MAE) of 1.

Self-Reinforced Composite Materials: Frictional Analysis and Its Implications for Prosthetic Socket Design.

Friction and wear characteristics play a critical role in the functionality and durability of prosthetic sockets, which are essential components in lower-limb prostheses. Traditionally, these sockets are manufactured from bulk polymers or composite materials reinforced with advanced carbon, glass, and Kevlar fibres. However, issues of accessibility, affordability, and sustainability remain, particularly in less-resourced regions.