937 results match your criteria: "Day hospital[Affiliation]"
Children (Basel)
December 2024
Division of Pediatric Urology of the Department of Urology and Human Reproductive Health, Rostov State Medical University, 344022 Rostov-on-Don, Russia.
Background: The urinary microbiota of healthy children has rarely been studied, and potential differences between boys and girls have not been addressed. Thus, this study aimed to compare the urinary microbiota of healthy prepubescent girls and boys.
Methods: We included healthy children aged between 4 and 10 years who were free of functional or organic urinary tract diseases and had no history of urinary tract infection.
Biomedicines
December 2024
Department of Nephrology, Hospital Universitari i Politècnic La Fe, 46026 Valencia, Spain.
Background: X-linked hypophosphatemia (XLH) is a rare disorder characterized by elevated levels of fibroblast growth factor 23 (FGF-23), leading to hypophosphatemia and complications in diagnosis due to its clinical heterogeneity. Metabolomic analysis, which examines metabolites as the final products of cellular processes, is a powerful tool for identifying in vivo biochemical changes, serving as biomarkers of pathological abnormalities, and revealing previously uncharted metabolic pathways.
Methods: A multicenter cross-sectional case-control study of adult patients diagnosed with XLH was conducted.
J Funct Morphol Kinesiol
December 2024
Department of Physical and Mental Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", 80100 Naples, Italy.
Background: This observational study investigates the efficacy of combining local muscle vibration (LMV) therapy and kinesiotaping using the McConnell method (KMcCM) in patients with patellofemoral pain syndrome (PFPS). PFPS is a prevalent knee condition characterized by anterior or medial knee pain exacerbated by activities that overload the patellofemoral joint.
Objective: The primary aim of this study was to evaluate the effectiveness of LMV combined with KMcCM in reducing pain and improving function in PFPS patients.
Haematologica
January 2025
For Anemia Foundation ETS, Genoa, Italy; Hematology Unit, IRCCS Giannina Gaslini, Genoa.
Not available.
View Article and Find Full Text PDFGeroscience
January 2025
ICube Laboratory UMR-7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), IMIS Team and IRIS Platform, University of Strasbourg and CNRS, Strasbourg, France.
The differential mechanisms between proteinopathies and neurodegeneration in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) remain unclear. To address this issue, we conducted a voxel-based morphometry and cerebrospinal fluid biomarker (α-synuclein, Aβ42, t-Tau and p-Tau) level correlation study in patients with DLB, AD and mixed cases (AD + DLB). Cerebrospinal fluid samples obtained by lumbar puncture and whole-brain T1-weighted images were collected in the AlphaLewyMA cohort.
View Article and Find Full Text PDFEpilepsia
January 2025
Unit of Innovative Treatments, Hospital de Pediatría JP Garrahan, Buenos Aires, Argentina.
Objective: Identifying factors influencing cannabidiol (CBD) exposure can optimize treatment efficacy and safety. We aimed to describe the population pharmacokinetics of CBD in children with drug-resistant developmental and epileptic encephalopathies (DEEs) and assess the influence of environmental, pharmacological, and clinical characteristics on CBD systemic exposure.
Methods: Data from two pharmacokinetic studies of patients aged 2-18 years with DEEs were included (N = 48 patients).
J Neurol
January 2025
Biogen, Milan, Italy.
Objective: In Italy, around 137,000 people live with multiple sclerosis, facing organizational complexities due to the current model's limited focus on proximity care. This project aims to define a proximity model, in accordance with recent developments in the Italian healthcare landscape, engaging over 150 healthcare stakeholders and potentially impacting approximately 14,000 patients.
Methods: An analysis was pursued to map the multiple sclerosis pathway, followed by interviews to capture the actual implementation in Italian Multiple Sclerosis Centers.
Int J Mol Sci
December 2024
Laboratory of Epigenetics, Research Centre for Medical Genetics, Moskvorechie st., 1, 115522 Moscow, Russia.
Homologous recombination repair deficiency (HRD) is involved in the development of high-grade serous ovarian carcinoma (HGSOC) and its elevated sensitivity to platinum-based chemotherapy. To investigate the heterogeneity of the HRD-positive HGSOC we evaluated the HRD status, including BRCA mutations, genomic scar score, and methylation status of genes in 352 HGSOC specimens. We then divided the HRD-positive cohort into three molecular subgroups, the BRCA mutation cohort (BRCA+), BRCA1 methylation cohort (Meth+), and the rest of the HRD+ cohort (HRD+BRCA-Meth-), and evaluated their first-line chemotherapy response, benefit from olaparib, and progression-free survival (PFS).
View Article and Find Full Text PDFMedicina (Kaunas)
December 2024
Rheumatology Department, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, 10126 Torino, Italy.
The treatment landscape for Rheumatoid Arthritis (RA) has evolved significantly with the introduction of Janus kinase inhibitors (JAKi), such as Tofacitinib (TOFA), which offer a new therapeutic option for patients who have failed or are intolerant to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs). Safety concerns, particularly related to cardiovascular and cancer risks, prompted a need for additional investigation in real-world clinical settings. This study aimed to evaluate the long-term effectiveness and predictors of response to TOFA in two subpopulations of RA patients, categorized by differing cardiovascular risk profiles.
View Article and Find Full Text PDFJ Pharmacopuncture
December 2024
School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.
Objectives: Postpartum hemorrhage is a leading cause of maternal mortality worldwide. Emerging evidence suggests that the sumac plant possesses astringent and anti-inflammatory properties that may help reduce menstrual bleeding. Therefore, this study aimed to determine the effect of sumac capsules on postpartum bleeding among women at risk of excessive bleeding.
View Article and Find Full Text PDFClin Neuropsychol
December 2024
Center for Language and Brain, HSE University, Moscow, Russia.
The Rey Auditory Verbal Learning Test (RAVLT) is a classic test used to assess episodic verbal memory in research and clinical practice. We aimed to adapt the RAVLT materials into Russian, provide performance norms across the adult lifespan for the Russian adaptation, and develop a mobile application for automated RAVLT administration across languages. We created three psycholinguistically matched alternative versions of the RAVLT materials in Russian and incorporated them into a new tablet application.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Centre for Healthy Brain Ageing, Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Introduction: Neuropsychiatric symptoms (NPSs) are common in dementia with Lewy bodies (DLB) but their neurobiological mechanisms are poorly understood.
Methods: NPSs and cognition were assessed annually in participants (DLB n = 222; Alzheimer's disease [AD] n = 125) from the European DLB (E-DLB) Consortium, and plasma phosphorylated tau-181 (p-tau181) and p-tau231 concentrations were measured at baseline.
Results: Hallucinations, delusions, and depression were more common in DLB than in AD and, in a subgroup with longitudinal follow-up, persistent hallucinations and NPSs were associated with lower p-tau181 and p-tau231 in DLB.
Sci Rep
December 2024
Department of Ophthalmology, Federal University of Goiás, Goiânia, 74605-020, Brazil.
This retrospective, comparative, multicenter study aimed to evaluate the real-world outcomes and predictors of failure of Gonioscopy-assisted transluminal trabeculotomy (GATT) at 12 months in glaucoma patients. Predictors of failure of absolute success in bilateral cases (422 eyes of 308 patients) included pre-operative intraocular pressure (IOP; IRR = 1.02; p = 0.
View Article and Find Full Text PDFDis Colon Rectum
December 2024
Department of Surgery, McGill University, Montreal, Quebec, Canada.
Background: Non-antibiotic outpatient treatment of acute uncomplicated diverticulitis is safe; however, uptake remains low.
Objective: To assess the success of non-antibiotic management of uncomplicated diverticulitis through a nurse clinician-led outpatient program.
Design: Retrospective audit from June 2022-March 2024.
J Eval Clin Pract
February 2025
Management and Diagnostic Innovations & Clinical Pathways Research Area, Neurorehabilitation and Adapted Physical Activity Day Hospital, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Background: Chewing is a fundamental motor activity, but there is no specific assessment tool in Italian for paediatric rehabilitation. The Karaduman Chewing Performance Scale (KCPS) is a performance-based assessment tool that allow to classify chewing performance in childhood.
Objective: To translate, culturally adapt and assess reliability, criterion validity and cross-cultural validity of the KCPS into Italian in a paediatric population.
J Cataract Refract Surg
December 2024
Department of Ophthalmology, Sorocaba Eye Hospital, Sorocaba Eye Bank, Sorocaba, São Paulo, Brazil.
Purpose: To investigate the effectiveness and safety of customized femtosecond laser-assisted corneal allogenic intrastromal ring segments (CAIRS) implantation in keratoconus patients with a history of intrastromal corneal ring segment (ICRS) explantation.
Setting: Sorocaba Eye Hospital (Hospital Oftalmológico de Sorocaba - HOS), Sorocaba, Brazil.
Design: Prospective case series.
J Investig Allergol Clin Immunol
December 2024
Internal Medicine Department, Dr. Balmis General University Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain.
Antibiotics (Basel)
November 2024
Department of Statistical Sciences, University of Bologna, 40126 Bologna, Italy.
Dalbavancin is a long-acting lipoglycopeptide, approved for treatment of skin and skin structure infections. Its PK/PD profile and safety allow for short hospital stays even in the case of difficult-to-treat infections requiring long courses of therapy, e.g.
View Article and Find Full Text PDFChildren (Basel)
November 2024
Division of Neuro-Urology, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
To evaluate neurogenic bladder and bowel dysfunction (NBBD) in children with cerebral palsy (CP) and acquired brain injury (ABI), a condition considered less frequent in those patients than in children with spinal cord injury (SCI), and to study the relationship between NBBD and disability grade in this population. We retrospectively reviewed the clinical data of all patients (aged 3-18 years old) admitted during a three-month observation in our neurorehabilitation department. Data collected were as follows: demographic parameters; disability status (Wee-FIM Scale, Gross Motor Function Classification System (GMFCS) and the Communication Function Classification System); and gastrointestinal and urological symptoms (diaries, Bristol scale, Pad Test and International Consultation on Incontinence Modular Questionnaire).
View Article and Find Full Text PDFRecenti Prog Med
November 2024
Uosd Day Hospital oncologico Giulianova - Sant'Omero, PO Maria SS. dello Splendore, Giulianova (Teramo).
Triple-negative breast cancer (TNBC) continues to be the most aggressive molecular subtype of breast cancer and the optimal therapeutic management is still a challenge. Due to the lack of "traditional" molecular targets, for decades, systemic treatment has been characterized by the use of classic cytotoxic drugs. In recent years, it has been proved that TNBC is not represented by a single pathology lack of specific features, but of different entities with distinct genetic, histological and clinical alterations.
View Article and Find Full Text PDFInt J Mol Sci
October 2024
Department of Internal Medicine, Oncologic Day Hospital, Hospital of Bressanone (SABES-ASDAA), 39042 Bressanone-Brixen, Italy.
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the third leading cause of cancer-related death worldwide. Liver transplantation (LT) is the best therapy for most patients with non-metastatic HCC. In recent years, the management of patients with HCC has considerably changed, thanks to the improvement of molecular biology knowledge and the introduction of immunotherapy.
View Article and Find Full Text PDFChild Adolesc Psychiatr Clin N Am
January 2025
Adolescent Crisis Stabilization Unit, Sheppard Pratt, Baltimore Washington Campus, Baltimore, MD 21204, USA; Sheppard Pratt, Howard County Clinic, 7200 Discovery Drive, Elkridge, MD 21075, USA. Electronic address:
Child Adolesc Psychiatr Clin N Am
January 2025
Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, USA. Electronic address:
The complexity of child behavioral health and the importance of transitioning from the most restrictive to an intermediate level of care such as a partial hospitalization program (PHP) for high-risk youth is highlighted in this study. While inpatient hospitalization stabilizes youth in imminent danger, PHPs offer intensive treatment of those requiring more support than traditional outpatient care but less intensive than inpatient hospitalization. The transition between levels of care is determined by the severity of symptoms, high-risk behaviors, and clinical progress with planned step-downs from inpatient settings to a PHP and crisis-driven step-ups from a PHP to inpatient.
View Article and Find Full Text PDFInt J Audiol
October 2024
The Midlands Hearing Implant Programme, Aston University Day Hospital, Aston University, Birmingham, United Kingdom.
Objective: To explore the process of paediatric cochlear implant assessment, from referral to implantation, from the perspective of parents, cochlear implant professionals, and through observations of clinics.
Design: Qualitative approach, using grounded theory methodology.
Study Sample: Twelve families with children under 5 years with permanent hearing loss referred for a cochlear implant or received an implant in the past year, and six professionals who refer or assess children for cochlear implants.
Epidemiol Prev
September 2024
Struttura Tecnico Operativa, Laboratorio di Ricerca per il Coinvolgimento dei Cittadini in Sanità, Dipartimento di Epidemiologia Medica, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano.
Registers collecting data from clinical practice (real world data) have gained increasing interest in recent years in the scientific, administrative, and regulatory fields. The value of longitudinal data collection in deepening knowledge about a specific pathology and its healthcare complexity is increasingly recognized. This article describes the development, organizational structure, and technical characteristics of the Italian Multiple Sclerosis and Related Disorders Register (RISM).
View Article and Find Full Text PDF