4 results match your criteria: "Davis Center for Aging and Regeneration[Affiliation]"
Polycystin-2, mechanosensing, and left-right asymmetry in autosomal dominant polycystic kidney disease.
Kidney Int
October 2023
Davis Center for Aging and Regeneration, Mount Desert Island Biological Laboratory, Bar Harbor, Maine 04609, USA.
Tubuloid as an alternative model of ADPKD.
Kidney Int
September 2023
Davis Center for Aging and Regeneration, Mount Desert Island Biological Laboratory, Bar Harbor, Maine, USA. Electronic address:
Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutants.
Dis Model Mech
December 2022
Department of Pharmacology and Toxicology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA.
Article Synopsis
- Meckel syndrome, nephronophthisis, Joubert syndrome, and Bardet-Biedl syndrome are linked to mutations in proteins at the ciliary transition zone, indicating these proteins may have different functions but can also lead to multiple syndromes from mutations in a single gene.
- A study analyzed ten zebrafish mutants for these TZ proteins, revealing variation in phenotypes that suggest specific tissue functions and highlighting that different outcomes can occur from mutations in the same gene.
- The research also showed that unique CRISPR/Cas9 techniques can replicate certain genetic phenotypes and has identified several new gene candidates associated with ciliary functions.
Top2a promotes the development of social behavior via PRC2 and H3K27me3.
Sci Adv
November 2022
Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 84112, USA.
Little is understood about the embryonic development of sociality. We screened 1120 known drugs and found that embryonic inhibition of topoisomerase IIα (Top2a) resulted in lasting social deficits in zebrafish. In mice, prenatal Top2 inhibition caused defects in social interaction and communication, which are behaviors that relate to core symptoms of autism.
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