Palliative care for colorectal cancer.

Most patients with stage IV colorectal cancer have a poor prognosis,but numerous palliative modalities are available today. When a cure is no longer possible, treatment is directed toward providing symptomatic relief. The data leave little doubt that surgical resection may provide good palliation.

The Kohonen self-organizing map: a tool for the clustering and alignment of single particles imaged using random conical tilt.

An important step in determining the three-dimensional structure of single macromolecules is to bring common features in the images into register through alignment and classification. Here, we took advantage of the striking computational properties of the Kohonen self-organizing map (SOM) to align and classify images of channels obtained by random conical geometry into more homogeneous subsets. First, we used simulations with artificially created images to deduce simple geometrical rules governing the mapping of bounded (differing in size and shape) and unbounded (differing in in-plane orientation) variations in the output plane.

Mapping brain size and cortical gray matter changes in elderly depression.

Background: In elderly depression, volumetric brain imaging findings suggest abnormalities of the frontal lobe, particularly the orbitofrontal cortex, and the hippocampus. No studies to date have mapped cortical abnormalities over the entire brain surface in major depression. Here, we conducted detailed spatial analyses of brain size and gray matter within the cortical mantle in elderly patients with major depression.

Milrinone facilitates resuscitation from cardiac arrest and attenuates postresuscitation myocardial dysfunction.

Background: Left ventricular (LV) dysfunction with a low cardiac index after successful CPR contributes to early death attributable to multiorgan failure, and an effective treatment has not been identified. The purpose of this study was to investigate the use of milrinone, a selective phosphodiesterase III inhibitor, as treatment for LV dysfunction after resuscitation.

Methods And Results: Ventricular fibrillation (VF) was induced electrically in 32 swine.

Targeted molecular therapy of GBM.

Major advances in molecular biology, cellular biology and genomics have substantially improved our understanding of cancer. Now, these advances are being translated into therapy. Targeted therapy directed at specific molecular alterations is already creating a shift in the treatment of cancer patients.

Normalized protein nitrogen appearance is correlated with hospitalization and mortality in hemodialysis patients with Kt/V greater than 1.20.

Objectives: Normalized protein nitrogen appearance (nPNA), also known as protein catabolic rate (nPCR), reflects the daily protein intake in maintenance hemodialysis (MHD) patients. Several studies indicate that nPNA and Kt/V correlate with clinical outcome and also with each other. Thus, the relationship between low nPNA and poor outcome could be due to uremia, low Kt/V or due to reported mathematical coupling between nPNA and Kt/V.