3,135 results match your criteria: "David Geffen School of Medicine at University of California.[Affiliation]"

Article Synopsis
  • The study by Bocanegra-Oyola et al. offers a qualitative and meta-analysis on the features of ocular pemphigoid.
  • It emphasizes the importance of improving diagnostic procedures to clearly distinguish ocular pemphigoid from a similar condition known as pseudopemphigoid.
  • This discussion highlights a critical need for better diagnostic methods to ensure accurate identification and treatment of these conditions.
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High symptom burden in female X-linked chronic granulomatous disease carriers.

Clin Immunol

November 2024

Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, MD, United States of America; Institute for Clinical and Translational Research, St. Petersburg, FL, United States of America; Cancer and Blood Disorders Institute, Johns Hopkins All Children's Hospital, St. Petersburg, FL, United States of America.

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Pediatrician Knowledge of Early Intervention Process as Contributor to Disparities in Management of Development Delay.

Matern Child Health J

November 2024

Department of Pediatrics, UCLA Mattel Children's Hospital and Children's Discovery & Innovation Institute, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.

Introduction: Lack of knowledge of Early Intervention (EI) is a barrier to developmental delay (DD) management. We aimed to examine the feasibility of measuring pediatricians' knowledge of EI, determine the distribution of EI knowledge, and determine factors associated with increased EI knowledge.

Methods: We conducted an exploratory cross-sectional study with a convenience sample from a local American Academy of Pediatrics chapter to administer a survey with 10 multiple-choice questions regarding the EI referral process, evaluation process, eligibility criteria and fee structure.

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Background: Incidence rates of autism, attention-deficit/hyperactivity disorder (ADHD), and gender dysphoria (GD) are rising not only in the general population, but particularly among children, adolescents, and young adults with eating disorders (EDs). While ED rates have risen during the COVID pandemic, trends in co-occurring autism, ADHD, and GD have yet to be investigated in detail or at scale by way of large electronic medical record data.

Objectives: To investigate trends in rates of co-occurring autism, ADHD, and GD among children, adolescents, and young adults with EDs in years prior to and during the COVID-19 pandemic.

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Vocal Fold Injury Produces Similar Biomechanical Outcomes in Male and Female Rabbits.

J Voice

September 2024

Department of Head and Neck Surgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California; Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California. Electronic address:

Objective: Sex differences in response to trauma and physiologic stressors have been identified in numerous organ systems but have not yet been defined in the larynx. The objective of this study was to develop an endoscopic vocal fold injury model in rabbits and to compare structural and functional outcomes between male and female subjects.

Study Design: Basic science study.

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Article Synopsis
  • Telomere biology disorders (TBD) are inherited conditions linked to short telomeres, with dyskeratosis congenita (DC) being a severe phenotype characterized by various physical symptoms.
  • A case study details a 2-year-old girl with specific symptoms (reticulated pigmentary changes and Terry's nails) who was found to have a TERT gene variant and short telomeres, but did not show the full range of TBD features.
  • The report emphasizes the need for awareness and diagnosis of TBD, even in patients who exhibit only mild or limited symptoms of classic DC.
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Objective: To compare morbidity burden captured from multimorbidity indices and aggregated measures of clinically meaningful categories captured in primary care community-based health center (CBHC) patients.

Data Sources And Study Setting: Electronic health records of patients seen in 2019 in OCHIN's national network of CBHCs serving patients in rural and underserved communities.

Study Design: Age-stratified analyses comparing the most common conditions captured by the Charlson, Elixhauser, and Multimorbidity Weighted (MWI) indices, and Classification Software Refined (CCSR) and Chronic Condition Indicator (CCI) algorithms.

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Background: A welcoming environment may influence patient care experiences, and it may be particularly relevant for underrepresented groups, such as women veterans at Veterans Health Administration (VA) facilities where they represent only 8-10% of patients. Challenges to ensuring a welcoming environment for women veterans may include unwelcome comments from male veterans and staff or volunteers and feeling unsafe inside or outside VA facilities. We assessed associations between reports of gender-related environment of care problems and patient-reported outcomes.

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Leveraging Generational Differences in the Gastroenterology Workforce to Promote Satisfaction and a Harmonious Work Environment.

Clin Gastroenterol Hepatol

November 2024

Division of Gastroenterology and Hepatology, Department of Medicine, University of Colorado Anschutz Medical Center, Aurora, Colorado; Rocky Mountain Regional Veterans Affairs Medical Center, Division of Gastroenterology, Aurora, Colorado. Electronic address:

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Reduction in polycyclic aromatic hydrocarbon exposure in Beijing following China's clean air actions.

Sci Bull (Beijing)

October 2024

Department of Environmental Health Sciences, Jonathan and Karin Fielding School of Public Health, University of California Los Angeles, Los Angeles 90095, USA. Electronic address:

Article Synopsis
  • The study investigates the effectiveness of China's clean air initiatives, APPCAP (2013-2017) and BSDW (2018-2020), in reducing polycyclic aromatic hydrocarbons (PAHs) exposure in Beijing, which are among the highest in the world.
  • Results show a significant decrease in PM-bound benzo[a]pyrene equivalents (BaPeq) by 96.6% from 2014 to 2021, primarily due to reduced emissions from traffic, coal, and biomass.
  • Additionally, PAH metabolite concentrations in urine samples from travelers showed a 52.3% decrease in Beijing, indicating improved air quality and reduced human exposure linked to these initiatives.
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Article Synopsis
  • The study evaluates two different antibody detection assays (MSD and Bio-Plex Pro) for their effectiveness in measuring antibodies against SARS-CoV-2, focusing on various antibody types (IgG, IgM, IgA) and antigens (RBD, N).
  • Results showed high concordance (90.5% for anti-RBD IgG and 87% for anti-N IgG) in determining sample status as positive or negative across the two assays, indicating they can reliably assess immune responses.
  • The research also found that participants treated with the monoclonal antibody bamlanivimab showed reduced IgG responses compared to those given a placebo, suggesting the treatment affects immune response
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Using 1998-2022 Women's Health Initiative (WHI) data, our study provides contemporary fracture data by race and ethnicity, specifically focusing on Hispanic and Asian women. Fractures of interest included any clinical, hip, and major osteoporotic fractures (MOFs). We utilized the updated race and ethnicity information collected in 2003, which included seven Asian and five Hispanic origin groups.

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Purpose: To assess the technical feasibility and safety of image-guided percutaneous biphasic monopolar pulsed electric field (PEF) ablation of primary and metastatic tumors.

Materials And Methods: With institutional review board (IRB) approval and Health Insurance Portability and Accountability Act (HIPAA) compliance, this retrospective, single-institution study cohort of 17 patients (mean age, 53.5 years; range, 20-94 years) with overall progressive disease underwent 26 PEF ablation procedures for 30 metastatic (90%) and primary (10%) target lesions in the thorax (n = 20), abdomen (n = 7), and head and neck (n = 3).

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Background: OpenAI's ChatGPT is a source of advanced online health information (OHI) that may be integrated into individuals' health information-seeking routines. However, concerns have been raised about its factual accuracy and impact on health outcomes. To forecast implications for medical practice and public health, more information is needed on who uses the tool, how often, and for what.

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A Comprehensive Assessment of Soft-tissue Sagging after Zygoma Reduction Surgery through Artificial Intelligence Analysis.

Plast Reconstr Surg Glob Open

August 2024

From the Department of Plastic and Reconstructive Surgery, iWELL Plastic Surgery Clinic, Seoul, South Korea.

Article Synopsis
  • Zygomatic bone overdevelopment can make the face look squarer, leading many to seek zygoma reduction surgery for a more oval facial shape, but this procedure can cause cheek tissue sagging.
  • This study utilized artificial intelligence (AI) to objectively assess soft-tissue changes in patients after zygoma reduction surgery, using methods such as tracking facial landmarks and analyzing changes in facial curvature.
  • The findings indicated no significant differences in cheek sagging before and after surgery, suggesting that AI could provide valuable objective evaluations in the field and potentially lead to advancements in predicting soft-tissue changes pre-surgery.
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Biomarkers and Endophenotypes of Post-traumatic Headaches.

Curr Pain Headache Rep

December 2024

UCLA Steve Tisch BrainSPORT Program, Department of Pediatrics/Division of Neurology and Department of Neurosurgery, UCLA Mattel Children's Hospital David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.

Purpose Of Review: To review existing literature on biomarkers for post-traumatic headache (PTH).

Recent Findings: Preclinical models and clinical findings have started to elucidate the biology that underlies PTH. Traumatic brain injury results in ionic flux, glutamatergic surge, and activation of the trigeminal cervical complex resulting in the release of pain neuropeptides.

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Article Synopsis
  • A novel ctDNA testing method shows potential for improving prognosis and treatment monitoring in diffuse large B-cell lymphoma (DLBCL) patients.
  • In a study of 50 DLBCL patients, ctDNA was detected in 95% pre-treatment, and higher baseline levels were linked to poorer outcomes, while clearance during treatment predicted better responses.
  • Overall, ctDNA clearance was a strong predictor of favorable patient outcomes and could lead to earlier detection of treatment responses compared to traditional imaging methods.
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Background: Prepubertal transgender, nonbinary, and gender-diverse (TGD) children (ie, those asserting gender identity, expressing gender-role behavior outside of culturally defined norms for their sex registered at birth, or both) are presenting in greater numbers to pediatric gender clinics across the United States and abroad. A large subset of TGD children experiences gender dysphoria, that is, distress that arises from the incongruence between gender identity and sex registered at birth. A lack of consensus exists regarding care for prepubertal TGD children due, in part, to a dearth of empirical research on longitudinal developmental trajectories of gender identity, role behavior, and gender dysphoria (when present).

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Article Synopsis
  • The study aimed to explore vaccination knowledge and barriers among minority adults, using a cross-sectional survey conducted in otolaryngology clinics and a cancer screening event.
  • Findings revealed low rates of HPV vaccination among both minority (17.67%) and their children (33.55%), with minorities displaying significantly lower knowledge about HPV and its link to cervical and head and neck cancers.
  • The primary reason minorities were not vaccinated was lack of knowledge about the HPV vaccine, suggesting that educational interventions could improve vaccination rates in this demographic.
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Article Synopsis
  • The 2022 European LeukemiaNet (ELN) classification predicts outcomes for younger acute myeloid leukemia (AML) patients but was tested for those aged 60 and older receiving lower-intensity treatment (LIT), involving 595 patients with varying risk levels.
  • Results showed that while ELN risk is predictive of overall survival, it fails to distinguish between favorable and intermediate risks, prompting further exploration into adverse-risk patients' molecular abnormalities.
  • A new "Beat-AML" risk classification was developed, combining favorable and intermediate risks and integrating mutation scoring, leading to better survival predictions for older AML patients and aiding treatment decisions with clear risk group delineations.
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